Zhang M, Liu J, Gu JN, Han K, Jia W, Li P, Sun Y, An N, Yang Z. Advances in endoscopic closure techniques for endoscopic full-thickness resection. World J Gastrointest Endosc 2025; 17(9): 107157 [DOI: 10.4253/wjge.v17.i9.107157]
Corresponding Author of This Article
Zhuo Yang, MD, PhD, Associate Chief Physician, Department of Endoscopy, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110016, Liaoning Province, China. yangzhuocy@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Sep 16, 2025; 17(9): 107157 Published online Sep 16, 2025. doi: 10.4253/wjge.v17.i9.107157
Advances in endoscopic closure techniques for endoscopic full-thickness resection
Meng Zhang, Jiao Liu, Jiang-Ning Gu, Ke Han, Wen Jia, Peng Li, Yong Sun, Na An, Zhuo Yang
Meng Zhang, Jiao Liu, Jiang-Ning Gu, Ke Han, Wen Jia, Peng Li, Yong Sun, Na An, Zhuo Yang, Department of Endoscopy, General Hospital of Northern Theater Command, Shenyang 110016, Liaoning Province, China
Co-first authors: Meng Zhang and Jiao Liu.
Co-corresponding authors: Na An and Zhuo Yang.
Author contributions: Zhang M and Liu J conceptualized and designed the study, drafted the manuscript, and approved the final version for publication, and they contributed equally to this work as co-first authors; Gu JN, Han K, and Jia W provided critical revision suggestions; Sun Y and Li P performed the literature search and preliminary screening; An N and Yang Z supervised the study, reviewed and revised the manuscript, provided constructive feedback, and oversaw the submission process; both An N and Yang Z have played important and indispensable roles in the manuscript as co-corresponding authors; Yang Z applied for and obtained the funds for this research project.
Supported by Shenyang Science and Technology, No. 22-321-32-15.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhuo Yang, MD, PhD, Associate Chief Physician, Department of Endoscopy, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110016, Liaoning Province, China. yangzhuocy@163.com
Received: March 18, 2025 Revised: May 13, 2025 Accepted: August 4, 2025 Published online: September 16, 2025 Processing time: 178 Days and 21.2 Hours
Abstract
Recently, the continuous advancement of endoscopic technology has led to the widespread application of endoscopic full-thickness resection (EFTR) in clinical practice. The crucial aspect of EFTR is the successful closure of the wound. Initially, endoscopic clip and nylon thread suturing was employed; subsequently, a variety of innovative suturing techniques based on that have been developed, driving ongoing technological innovation in this field. Given the unique characteristics of EFTR, an increasing number of specialized endoscopic suturing devices are being explored. This article aims to systematically evaluate the efficacy, limitations, and clinical applicability of current endoscopic closure techniques for EFTR-induced defects.
Core Tip: Endoscopic full-thickness resection (EFTR) has emerged as a valuable technique for treating subepithelial lesions. Successful closure of EFTR-induced defects is crucial for minimizing complications. Endoscopic clip suturing has evolved into advanced methods such as over-the-scope clips, endoloop-assisted techniques, and novel suturing devices like OverStitch, Full-Thickness Resection Device (FTRD), OverStitch, etc. This review highlights the latest advancements in EFTR closure techniques, emphasizing their efficacy, limitations, and clinical applications to guide optimal treatment selection.
