Nishizawa T, Toyoshima O, Yoshida S, Takahashi Y, Nakagawa H, Mizutani H, Kataoka Y, Kanazawa T, Ebinuma H, Hata K. Advantages of new generation colonoscopes on adenoma detection: A propensity-score matching study. World J Gastrointest Endosc 2025; 17(6): 108146 [DOI: 10.4253/wjge.v17.i6.108146]
Corresponding Author of This Article
Osamu Toyoshima, MD, PhD, Director, Department of Gastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-Ku, Tokyo 157-0066, Japan. t@ichou.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Toshihiro Nishizawa, Hirotoshi Ebinuma, Department of Gastroenterology and Hepatology, International University of Health and Welfare, Narita Hospital, Narita 286-8520, Japan
Toshihiro Nishizawa, Osamu Toyoshima, Shuntaro Yoshida, Yoshiyuki Takahashi, Hideki Nakagawa, Hiroya Mizutani, Yosuke Kataoka, Takamitsu Kanazawa, Keisuke Hata, Department of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan
Hideki Nakagawa, Hiroya Mizutani, Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan
Takamitsu Kanazawa, Department of Gastroenterology, JR Tokyo General Hospital, Tokyo 151-8528, Japan
Keisuke Hata, Department of Surgical Oncology, University of Tokyo, Tokyo 1138655, Japan
Author contributions: Nishizawa T was responsible for endoscopic diagnosis, article writing, and statistical analysis; Toyoshima O was responsible for endoscopic diagnosis and statistical analysis; Yoshida S, Takahashi Y, Nakagawa H, Mizutani H, Kataoka Y, and Kanazawa T were responsible for endoscopic diagnosis; Ebinuma H was responsible for provision of literature and expenses related to the research; Hata K was responsible for final scrutiny of the study; all authors contributed to the study design, article review, and final manuscript approval.
Institutional review board statement: This study was approved by the Ethics Committee of the Certified Institutional Review Board of the Yoyogi Mental Clinic (No. RKK227).
Informed consent statement: The need for patient consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: The authors declare no conflicts of interest associated with this manuscript.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Osamu Toyoshima, MD, PhD, Director, Department of Gastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-Ku, Tokyo 157-0066, Japan. t@ichou.com
Received: April 7, 2025 Revised: April 17, 2025 Accepted: May 20, 2025 Published online: June 16, 2025 Processing time: 66 Days and 4.4 Hours
Abstract
BACKGROUND
Recently, Olympus Corporation released new scopes (XZ1200/EZ1500). However, there have been few reports on this topic, although improvement in adenoma detection rate (ADR) by texture and color enhancement imaging (TXI) or computer-aided detection system (CAD) has been reported.
AIM
To investigate the effects of the scope on the detection of adenomas and sessile serrated lesions (SSLs).
METHODS
The subjects were patients who underwent pancolonic chromoendoscopy using the EVIS X1 video system center between May 2023 and October 2024. The patients were divided into the new (CF-XZ1200/CF-EZ1500) and 290 series (CF-HQ290Z/PCF-H290Z) groups. Propensity score matching was performed for age, sex, examination purpose, endoscopist, preparation, TXI use, and CAD use. The effects of the scope were analyzed in terms of the ADR, SSL detection rate (SDR), and mean number of adenomas per colonoscopy (APC).
RESULTS
Of the 7014 patients enrolled, 2138 pairs were extracted by propensity score matching (mean age 55.4 years, 45.5% male). The new scopes group had a significantly higher ADR than the 290 series group [51.5% vs 45.5%, odds ratio (OR) = 1.27, 95%CI: 1.13-1.43, P < 0.001]. Similarly, the new scopes group had significantly higher SDR (7.8% vs 5.7%, OR = 1.41, 95%CI: 1.11-1.80, P = 0.005) and APC (0.90 vs 0.76, OR = 1.11, 95%CI: 1.05-1.17, P < 0.001) than the 290 series group.
CONCLUSION
In conclusion, the new scope (CF-XZ1200/CF-EZ1500) enhanced the detection of adenomas and SSLs compared to the old ones (290 series).
Core Tip: Recently, Olympus Corporation released new scopes (XZ1200/EZ1500). This propensity score matching study showed that the new scopes (CF-XZ1200/CF-EZ1500) enhanced the detection of adenomas and sessile serrated lesions compared to the old ones (290 series). The improvement in image quality with this model change was remarkable.
