Dhali A, Maity R, Rathna RB, Biswas J. Confocal laser endomicroscopy for gastric neoplasm. World J Gastrointest Endosc 2024; 16(9): 540-544 [PMID: 39351178 DOI: 10.4253/wjge.v16.i9.540]
Corresponding Author of This Article
Arkadeep Dhali, MBBS, MPH, PGCert Clin Ed, FRSPH, NIHR Academic Clinical Fellow, Department of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom. arkadipdhali@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Sep 16, 2024; 16(9): 540-544 Published online Sep 16, 2024. doi: 10.4253/wjge.v16.i9.540
Confocal laser endomicroscopy for gastric neoplasm
Arkadeep Dhali, Rick Maity, Roger B Rathna, Jyotirmoy Biswas
Arkadeep Dhali, Department of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield S10 2JF, United Kingdom
Arkadeep Dhali, School of Medicine and Population Health, University of Sheffield, Sheffield S10 2HQ, United Kingdom
Rick Maity, General Medicine, Institute of Post Graduate Medical Education and Research, Kolkata 700020, India
Roger B Rathna, Department of Internal Medicine, University Hospitals Leicester NHS Trust, Leicester Royal Infirmary, Leicester LE1 5WW, United Kingdom
Jyotirmoy Biswas, General Medicine, College of Medicine and Sagore Dutta Hospital, Kolkata 700058, India
Co-first authors: Arkadeep Dhali and Rick Maity.
Author contributions: Dhali A conceptualized the article, conducted literature review and wrote the primary manuscript; Maity R conducted literature review and wrote the primary manuscript; Rathna R conducted literature review and wrote the primary manuscript; Biswas J conducted literature review and wrote the primary manuscript. All authors agreed with the final version of the manuscript.
Conflict-of-interest statement: All authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arkadeep Dhali, MBBS, MPH, PGCert Clin Ed, FRSPH, NIHR Academic Clinical Fellow, Department of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom. arkadipdhali@gmail.com
Received: March 13, 2024 Revised: August 22, 2024 Accepted: August 28, 2024 Published online: September 16, 2024 Processing time: 182 Days and 8.9 Hours
Abstract
Confocal laser endomicroscopy (CLE) is a novel endoscopic modality that provides real-time histological information via high-resolution magnified view of the mucosa. CLE has a higher sensitivity, specificity, and diagnostic accuracy in detecting atrophic gastritis as compared to chromoendoscopy and narrow-band imaging. It can even predict low-grade and high-grade intraepithelial neoplasia by analyzing gastric pit patterns. CLE may have some advantages over the standard biopsy protocol, such as higher diagnostic yield and fewer biopsy requirements. Its diagnostic accuracy in detecting superficial gastric cancer is higher than that of white-light endoscopy. Inherent limitations, such as a narrow field of vision, can be surpassed by technological advancements and integration with other detection methods. Artificial intelligence holds promise in automated analysis of histopathological images. Thus, CLE can be helpful in screening for early gastric cancer and may help reduce the risk of complications from repeated biopsies, such as mucosal damage, bleeding, and infection.
Core Tip: Confocal laser endomicroscopy is a new imaging technique used during endoscopy procedures to evaluate the mucosa in vivo. Diagnosing and monitoring early cancer in the upper gastrointestinal tract can be effectively achieved through the use of this tool. Minimizing the number of biopsies required is one of the main benefits of this technology, while still maintaining a high diagnostic sensitivity rate. This helps to reduce the risk of complications, such as mucosal damage, bleeding, and infection, that may be caused by repeated biopsies.
