Kyoto classification in patients who developed multiple gastric carcinomas after Helicobacter pylori eradication

doi:10.4253/wjge.v12.i9.276

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 12, Issue 9

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (10575)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Tables (1-2) series.

Item

Count

PDF

623

WORD

357

HTML

3391

Tables (1-2)

568

Sum=4939

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

492

Download

1696

Sum=2188

Publishing Process of This Article

Item

Count

Browse

970

Download

2479

Sum=3449

Sep 16, 2020 (publication date) through Mar 1, 2026

Times Cited of This Article

Times Cited (11)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Endoscopy

ISSN

1948-5190

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Retrospective Study

World J Gastrointest Endosc. Sep 16, 2020; 12(9): 276-284
Published online Sep 16, 2020. doi: 10.4253/wjge.v12.i9.276

Kyoto classification in patients who developed multiple gastric carcinomas after Helicobacter pylori eradication

Kosuke Sakitani, Toshihiro Nishizawa, Akira Toyoshima, Shuntaro Yoshida, Tatsuya Matsuno, Tomoharu Yamada, Masatoshi Irokawa, Yoshiyuki Takahashi, Yousuke Nakai, Osamu Toyoshima, Kazuhiko Koike

Kosuke Sakitani, Toshihiro Nishizawa, Shuntaro Yoshida, Tatsuya Matsuno, Tomoharu Yamada, Masatoshi Irokawa, Yoshiyuki Takahashi, Osamu Toyoshima, Department of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan

Kosuke Sakitani, Department of Gastroenterology, Sakitani Endoscopy Clinic, Chiba 275-0026, Japan

Toshihiro Nishizawa, Department of Gastroenterology, International University of Health and Welfare, Narita Hospital, Chiba, 286-8520, Japan

Akira Toyoshima, Department of Colorectal Surgery, Japanese Red Cross Medical Center, Tokyo 150-8935, Japan

Tatsuya Matsuno, Tomoharu Yamada, Yousuke Nakai, Osamu Toyoshima, Kazuhiko Koike, Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan

Author contributions: Sakitani K wrote the manuscript; Sakitani K, Nishizawa T, Toyoshima A, Yoshida S, Matsuno T, Yamada T, Irokawa M, Takahashi Y, Toyoshima O collected and analyzed the data and revised the manuscript; Nakai Y, Koike K and Toyoshima O supervised the study; Toyoshima O conceived and designed the study.

Institutional review board statement: This retrospective study was approved by the Ethical Review Committee of Hattori Clinic on September 6, 2019 (approval no. S1909-U06).

Informed consent statement: Patients were not required to give informed consent the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.

Conflict-of-interest statement: The authors declare that there is no conflict of interest.

Data sharing statement: No additional data are available.

Corresponding author: Osamu Toyoshima, MD, Doctor, Department of Gastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo 157-0066, Japan. t@ichou.com

Received: June 10, 2020
Peer-review started: June 10, 2020
First decision: July 21, 2020
Revised: July 29, 2020
Accepted: August 15, 2020
Article in press: August 15, 2020
Published online: September 16, 2020
Processing time: 91 Days and 23.7 Hours

Abstract

BACKGROUND

Endoscopic Kyoto classification predicts gastric cancer risk; however, the score in the patients with primary gastric cancer after Helicobacter pylori (H. pylori) eradication therapy is unknown.

AIM

To elucidate the Kyoto classification score in patients with both single gastric cancer and multiple gastric cancers developed after H. pylori eradication.

METHODS

The endoscopist recorded the Kyoto classification at the endoscope and the Kyoto classification score at the time of the first diagnosis of gastric cancer after H. pylori eradication. The score was compared between single gastric cancer group and multiple gastric cancers group.

RESULTS

The Kyoto score at the time of diagnosis of 45 cases of gastric cancer after H. pylori eradication was 4.0 points in average. The score was 3.8 points in the single gastric cancer group, and 5.1 points in the multiple gastric cancers group. The multiple group had a significantly higher score than the single group (P = 0.016). In the multiple gastric cancers group, all the patients (7/7) had 5 or higher Kyoto score, while in single gastric cancer group, the proportion of patients with a score of 5 or higher was less than half, or 44.7% (17/38).

CONCLUSION

Patients diagnosed with gastric cancer after H. pylori eradication tended to have advanced gastritis. In particular, in cases of multiple gastric cancers developed after H. pylori eradication, the endoscopic Kyoto classification score tended to be 5 or higher in patients with an open type atrophic gastritis and the intestinal metaplasia extended to the corpus.

Keywords: Kyoto classification; Gastric cancer; Helicobacter pylori; Eradication therapy; Metachronous; Intestinal metaplasia

Core Tip: This is a retrospective study to elucidate the endoscopic Kyoto classification score in patients with both single gastric cancer and multiple gastric cancers developed after Helicobacter pylori (H. pylori) eradication. The Kyoto score of 45 cases of gastric cancer after H. pylori eradication was 4.0 points in average. The score was 3.8 points in the single gastric cancer group, and 5.1 points in the multiple gastric cancers group. In cases of multiple gastric cancers, the Kyoto classification score tended to be 5 or higher with an open type atrophic gastritis and the intestinal metaplasia extended to the corpus.