Prospective Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Nov 16, 2018; 10(11): 348-353
Published online Nov 16, 2018. doi: 10.4253/wjge.v10.i11.348
Submucosal injection of platelet-rich plasma in endoscopic resection of large sessile lesions
Vicente Lorenzo-Zúñiga, Vicente Moreno de Vega, Ramón Bartolí, Ingrid Marín, Noemí Caballero, Ignacio Bon, Jaume Boix
Vicente Lorenzo-Zúñiga, Vicente Moreno de Vega, Ramón Bartolí, Ingrid Marín, Noemí Caballero, Ignacio Bon, Jaume Boix, Department of Gastrointestinal Endoscopy, University Hospital Germans Trias/CIBERehd, Barcelona 08916, Spain
Author contributions: Lorenzo-Zúñiga V, Moreno de Vega V and Boix J contributed to the design of the study and performed the colonoscopies; Lorenzo-Zúñiga V and Bartolí R performed the data analysis and wrote the document; Marín I, Caballero N, and Bon I have revised the manuscript.
Institutional review board statement: The study was reviewed and approved by the institutional review board and Ethics Committee of University Hospital Germans Trias.
Informed consent statement: All study participants provided written consent prior to study enrolment.
Clinical trial registration: Study registered at ClinicalTrials.gov: NCT02931149.
Conflict-of-interest statement: The authors of this manuscript having no conflicts of interest to disclose.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Vicente Lorenzo-Zúñiga, MD, Professor, Department of Gastrointestinal Endoscopy, University Hospital Germans Trias, Carretera del Canyet s/n, Badalona 08916, Spain. vlorenzo.germanstrias@gencat.cat
Telephone: 00-34-934978866
Received: May 12, 2018
Peer-review started: May 12, 2018
First decision: July 9, 2018
Revised: August 8, 2018
Accepted: October 8, 2018
Article in press: October 10, 2018
Published online: November 16, 2018
Processing time: 188 Days and 16.1 Hours
Abstract
AIM

To prospectively evaluate the efficacy of submucosal injection of platelet-rich plasma (PRP) on endoscopic resection of large sessile lesions.

METHODS

Eleven patients were submitted to endoscopic mucosal resection (EMR) with prior injection of PRP, obtained at the time of endoscopy. Patients were followed during 1 mo. The incidence of adverse events (delayed bleeding or perforation) and the percentage of mucosal healing (MHR) after 4 wk were registered.

RESULTS

EMR was performed in 11 lesions (46.4 mm ± 4 mm, range 40-70 mm). Delayed bleeding or perforation was not observed in any patient. Mean ulcerated area at baseline was 22.7 cm2 ± 11.7 cm2 whereas at week 4 were 2.9 cm2 ± 1.5 cm2. Patients treated with PRP showed a very high MHR after 4 wk (87.5%).

CONCLUSION

PRP is an easy-to-obtain solution with proven and favourable biological activities that could be used in advanced endoscopic resection.

Keywords: Platelet-rich plasma; Endoscopic mucosal resection; Submucosal injection; Large lesions

Core tip: This was a prospective single-center study to evaluate the efficacy of submucosal injection of platelet-rich plasma (PRP) on 11 patients submitted to endoscopic resection of large lesions. PRP as lifting solution proved absence of delayed bleeding or perforation and strong healing activity.