Case Report
Copyright ©2009 Baishideng. All rights reserved.
World J Gastrointest Endosc. Oct 15, 2009; 1(1): 72-75
Published online Oct 15, 2009. doi: 10.4253/wjge.v1.i1.72
Colonoscopy polypectomy management in Glanzmann’s thrombasthenia
Dimple Raina, Arvind Movva, Fadi Rahhal, Khomani Abderrahim, Robert Schade, Sherman M Chamberlain
Dimple Raina, Arvind Movva, Fadi Rahhal, Khomani Abderrahim, Robert Schade, Sherman M Chamberlain, Section of Gastroenterology, Medical College of Georgia, Augusta, GA 30912, United States
Author contributions: Raina D and Chamberlain SM performed procedures, wrote and edited the paper; Movva A and Rahhal F performed procedures and edited the paper; Khomani A wrote and edited the paper; Schade R edited the paper.
Correspondence to: Sherman M Chamberlain, MD, Associate Professor of Medicine, Section of Gastroenterology, Medical College of Georgia, BBR-2538 1120 15th Street, Augusta, GA 30912, United States. schamberlain@mail.mcg.edu
Telephone: +1-706-7212238 Fax: +1-706-7210331
Received: January 16, 2009
Revised: March 2, 2009
Accepted: March 9, 2009
Published online: October 15, 2009
Abstract

Glanzmann's thrombasthenia (GT) is a rare autosomal recessive bleeding syndrome characterized by abnormal Glycoprotein IIb/IIIa complex (GIIb/IIIa) on platelets with resultant abnormality in platelet aggregation. There is very little information regarding polypectomy management in GT. We report a single patient with this rare disease, who underwent sequential endoscopic management of large colon polyps. Polypectomy in our GT patient was complicated by immediate and delayed bleeding. Multiple clips used after standard cautery polypectomy for a polyp 10 mm or larger in our GT patient, was most effective in preventing immediate and delayed post-polypectomy bleeding than other known therapeutic approaches. We favor preemptive use of multiple clips in large polypectomy defects for GT patients and we may argue the added cost may be offset by the reduction in the need for blood products, and by averting or shortening potential hospitalizations.

Keywords: Glanzmann’s thrombasthenia; Polypectomy; Post-polypectomy bleeding