Factors associated with long-term survival after liver transplantation: A retrospective cohort study

doi:10.4254/wjh.v9.i8.427

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Hepatol. Mar 18, 2017; 9(8): 427-435
Published online Mar 18, 2017. doi: 10.4254/wjh.v9.i8.427

Table 1 Patient characteristics directly before transplantation

	Patients who survived (n = 68)	Patients who died (n = 46)	P-value (χ² test)
Male	39 (57%)	31 (67%)	NS
Age, yr (median, SD)	16-65 (50.5, 13)	17-69 (56.0, 12)	0.009
BMI, range kg/m² (median, SD)	18-33 (23.1, 3)	15-29 (25.9, 4)	0.029
Pre-LTx creatinine, mg/dL (median, SD)	0.4-3.5 (1.0, 0.5)	0.3-2.9 (1.1, 0.6)	NS
GFR, mL/min (median, SD)	15.3-230.2 (73.3, 38.1)	22.6- 240.4 (62.5, 48.0)	NS
ALT, U/L (median, SD)	4-2610 (35.5, 449.5)	6-1566 (19.5, 339.0)	NS
Gamma-GT, U/L (median, SD)	7-374 (47.0, 8)	13-184 (43.0, 45)	NS
Bilirubin, mg/dL (median, SD)	0.4-28.1 (2.4, 5.7)	0.4-28.3 (2.4, 5.8)	NS
Warm ischemia time, min (median, SD)	25-100 (50.0, 18)	22-75 (54.0, 15)	NS
Cold ischemia time, min (median, SD)	242-940 (542.5, 157)	174-825 (521.0, 146)	NS
Donor age, yr (median, SD)	12-70 (36.5, 16)	13-75 (41.0, 1)	NS
Donor BMI, kg/m² (median, SD)	17-30 (23.5, 3)	18-31 (24.2, 2)	NS
Underlying diagnosis n (%)
HCC	2 (3)	3 (6)	NS
Alcohol toxic liver cirrhosis	12 (18)	13 (27)	NS
PSC	4 (6)	2 (4)	NS
Autoimmune	5 (8)	2 (4)	NS
HCV cirrhosis	9 (14)	6 (13)	NS
HBV infection	16 (24)	5 (10)	0.049
Other	18 (27)	17 (35)	NS

ALT: Alanine aminotransferase; BMI: Body mass index; OLT: Orthotopic liver transplantation; HCV: Hepatitis C virus; HBV: Hepatitis B virus; NS: No statistically significant difference; GFR: Glomerular filtration rate; HCC: Hepatocellular carcinoma; PSC: Primary sclerosing cholangitis.

Table 2 Comparison of survival according to age, body mass index and hepatitis B virus status in a Eurotransplant control cohort (n = 2973)¹

	Patients who survived n (%)	Patients who died n (%)	P-value (χ² test)
Age below 53 yr (n = 1809)	1156 (64)	653 (36)
Age above 53 yr (n = 1145)	520 (45)	625 (55)	< 0.001
BMI below 24 kg/m² (n = 1454)	880 (61)	574 (39)
BMI above 24 kg/m² (n = 1493)	796 (53)	697 (47)	< 0.001
Hepatitis B as underlying disease (n = 255)	170 (67)	85 (33)
Non-hepatitis B patients (n = 1705)	946 (55)	759 (45)	< 0.001

¹Data for age, BMI and hepatitis B virus status were not available for the total cohort. BMI: Body mass index.

Citation: Pischke S, Lege MC, von Wulffen M, Galante A, Otto B, Wehmeyer MH, Herden U, Fischer L, Nashan B, Lohse AW, Sterneck M. Factors associated with long-term survival after liver transplantation: A retrospective cohort study. World J Hepatol 2017; 9(8): 427-435
URL: https://www.wjgnet.com/1948-5182/full/v9/i8/427.htm
DOI: https://dx.doi.org/10.4254/wjh.v9.i8.427