Copyright
©The Author(s) 2017.
World J Hepatol. Jan 18, 2017; 9(2): 99-105
Published online Jan 18, 2017. doi: 10.4254/wjh.v9.i2.99
Published online Jan 18, 2017. doi: 10.4254/wjh.v9.i2.99
Table 1 Demographics and clinical variables categorized by transjugular intrahepatic porto-systemic shunt status
Variables | TIPS on waitlist (n = 1366; % or mean ± SD) | Non TIPS on waitlist (n = 31417; % or mean ± SD) | P-values |
Male candidate | 943 (69) | 21374 (68) | 0.43 |
Candidate race | < 0.001 | ||
White | 1072 (78.4) | 23063 (73.4) | |
Black | 75 (5.4) | 2865 (9.1) | |
Other | 219 (16) | 5489 (17.4) | |
Diabetes mellitus | 380 (28) | 7769 (24.8) | 0.009 |
ALD | 311 (22.7) | 6615 (21) | 0.13 |
Hepatic encephalopathy | 0.01 | ||
None | 373 (27.3) | 8409 (26.7) | |
Grade 1-2 | 925 (67.7) | 20790 (66.1) | |
Grade 3-4 | 68 (4.9) | 2218 (7) | |
Arterial hypertension | 68 (14.8) | 2254 (19.7) | 0.01 |
Age | 53.5 ± 8.5 | 53.6 ± 9.3 | 0.65 |
MELD score at listing | 16.6 ± 6.6 | 19.66 ± 8.8 | < 0.001 |
Creatinine | 1.2 ± 0.8 | 1.4 ± 1.2 | < 0.001 |
Bilirubin | 4.1 ± 6.3 | 6.61 ± 9.0 | < 0.001 |
INR | 1.5 ± 0.4 | 1.7 ± 0.8 | < 0.001 |
Albumin | 2.9 ± 0.6 | 2.9 ± 0.6 | 0.66 |
BMI at list entry | |||
Continuous (kg/m2) | 28.8 ± 5.6 | 28.8 ± 5.7 | 0.89 |
Dichotomous (≥ 26 kg/m2) | 905 (66.4) | 20747 (66.2) | 0.85 |
Cold ischemia time | |||
Continuous (h) | 7.1 ± 3.7 | 6.9 ± 3.5 | 0.03 |
Dichotomous (> 12 h) | 66 (5.0) | 1360 (4.5) | 0.38 |
MELD score at transplantation | 23.1 ± 9.1 | 22.6 ± 9.7 | 0.03 |
Table 2 Comparison of various outcomes on univariate analysis on waitlist and post liver transplant
TIPS on waitlist (n = 1366) % or mean ± SD | No TIPS on waitlist (n = 31417) % or mean ± SD | P-values | |
Days on LT waitlist | 408 ± 552.6 | 183 ± 330.5 | < 0.001 |
Mortality within 30 d | 46 (3.5) | 915 (3.0) | 0.344 |
Length of hospital stay | 17.58 ± 22.4 | 16.62 ± 22.1 | 0.118 |
Re-LT at 30 d | 15 (1.1) | 560 (1.8) | 0.06 |
Table 3 Multivariable logistic regression analysis to assess the impact of transjugular intrahepatic porto-systemic shunt on 30-d mortality after liver transplant
Variable | OR (95%CI) | P-values |
TIPS | 1.26 (0.90-1.75) | 0.17 |
Male candidate | 0.83 (0.71-0.95) | 0.01 |
Candidate race | ||
White | Ref. | |
Black | 1.08 (0.85-1.37) | 0.54 |
Other | 1.08 (0.90-1.29) | 0.40 |
Diabetes mellitus | 1.12 (0.95-1.31) | 0.17 |
ALD | 0.89 (0.74-1.07) | 0.22 |
Hepatic encephalopathy | ||
None | Ref. | |
Grade 1-2 | 0.86 (0.73-1.01) | 0.06 |
Grade 3-4 | 1.12 (0.85-1.47) | 0.41 |
Age | 1.02 (1.01-1.03) | < 0.001 |
MELD score | 1.02 (1.00-1.04) | 0.05 |
Creatinine | 1.03 (0.97-1.10) | 0.33 |
Bilirubin | 1.01 (1.00-1.02) | 0.008 |
INR | 0.97 (0.86-1.09) | 0.59 |
Albumin | 0.88 (0.79-0.98) | 0.03 |
BMI | 1.00 (0.99-1.02) | 0.86 |
Cold ischemia time | 1.04 (1.02-1.05) | < 0.001 |
Table 4 Multivariable logistic regression analysis to assess the impact of transjugular intrahepatic porto-systemic shunt on retransplantation
Variable | OR (95%CI) | P-values |
TIPS | 0.61 (0.36-1.05) | 0.07 |
Male candidate | 1.02 (0.85-1.24) | 0.81 |
Candidate race | ||
White | Ref. | |
Black | 1.22 (0.91-1.64) | 0.18 |
Other | 1.05 (0.83-1.32) | 0.69 |
Diabetes mellitus | 0.98 (0.78-1.21) | 0.83 |
ALD | 0.98 (0.78-1.24) | 0.90 |
Hepatic encephalopathy | ||
None | Ref. | |
Grade 1-2 | 0.92 (0.76-1.13) | 0.44 |
Grade 3-4 | 1.02 (0.69-1.51) | 0.91 |
Age | 0.97 (0.96-0.98) | < 0.001 |
MELD score | 0.99 (0.97-1.02) | 0.51 |
Creatinine | 0.87 (0.77-0.99) | 0.03 |
Bilirubin | 0.99 (0.98-1.02) | 0.54 |
INR | 1.01 (0.86-1.18) | 0.9 |
Albumin | 1.03 (0.89-1.19) | 0.65 |
BMI | 1.005 (0.98-1.02) | 0.54 |
Cold ischemia time | 1.05 (1.03-1.07) | < 0.001 |
Table 5 Ordinary least squares regression to assess the impact of transjugular intrahepatic porto-systemic shunt on length of hospital stay after liver transplant
Variable | β (95%CI) | P-values |
TIPS | 2.16 (0.92-3.38) | 0.001 |
Male candidate | -1.99 (-2.52-1.46) | < 0.001 |
Candidate race | ||
White | Ref. | |
Black | -1.58 (-2.46-0.69) | < 0.001 |
Other | 0.11 (-0.53-0.77) | 0.72 |
Diabetes mellitus | 0.52 (-0.05-1.10) | 0.07 |
ALD | 0.17 (-0.44-0.79) | 0.57 |
Hepatic encephalopathy | ||
None | Ref. | |
Grade 1-2 | -0.10 (-0.66-0.46) | 0.73 |
Grade 3-4 | 3.46 (2.37-4.55) | < 0.001 |
Age | 0.09 (0.06-0.11) | < 0.001 |
MELD score | 0.37 (0.31-0.44) | < 0.001 |
Creatinine | 0.05 (-0.21-0.31) | 0.71 |
Bilirubin | 0.03 (-0.008-0.08) | 0.1 |
INR | -1.06 (-1.50-0.61) | < 0.001 |
Albumin | -0.63 (-1.01-0.24) | 0.001 |
BMI | -0.05 (-0.100-0.01) | 0.01 |
Cold ischemia time | 0.36 (0.29-0.43) | < 0.001 |
Constant | 7.83 (5.38-10.27) | < 0.001 |
- Citation: Mumtaz K, Metwally S, Modi RM, Patel N, Tumin D, Michaels AJ, Hanje J, El-Hinnawi A, Hayes Jr D, Black SM. Impact of transjugular intrahepatic porto-systemic shunt on post liver transplantation outcomes: Study based on the United Network for Organ Sharing database. World J Hepatol 2017; 9(2): 99-105
- URL: https://www.wjgnet.com/1948-5182/full/v9/i2/99.htm
- DOI: https://dx.doi.org/10.4254/wjh.v9.i2.99