Retrospective Cohort Study
Copyright ©The Author(s) 2017.
World J Hepatol. Jan 18, 2017; 9(2): 99-105
Published online Jan 18, 2017. doi: 10.4254/wjh.v9.i2.99
Table 1 Demographics and clinical variables categorized by transjugular intrahepatic porto-systemic shunt status
VariablesTIPS on waitlist (n = 1366; % or mean ± SD)Non TIPS on waitlist (n = 31417; % or mean ± SD)P-values
Male candidate943 (69)21374 (68)0.43
Candidate race< 0.001
White1072 (78.4)23063 (73.4)
Black75 (5.4)2865 (9.1)
Other219 (16)5489 (17.4)
Diabetes mellitus380 (28)7769 (24.8)0.009
ALD311 (22.7)6615 (21)0.13
Hepatic encephalopathy0.01
None373 (27.3)8409 (26.7)
Grade 1-2925 (67.7)20790 (66.1)
Grade 3-468 (4.9)2218 (7)
Arterial hypertension68 (14.8)2254 (19.7)0.01
Age53.5 ± 8.553.6 ± 9.30.65
MELD score at listing16.6 ± 6.619.66 ± 8.8< 0.001
Creatinine1.2 ± 0.81.4 ± 1.2< 0.001
Bilirubin4.1 ± 6.36.61 ± 9.0< 0.001
INR1.5 ± 0.41.7 ± 0.8< 0.001
Albumin2.9 ± 0.62.9 ± 0.60.66
BMI at list entry
Continuous (kg/m2)28.8 ± 5.628.8 ± 5.70.89
Dichotomous (≥ 26 kg/m2)905 (66.4)20747 (66.2)0.85
Cold ischemia time
Continuous (h)7.1 ± 3.76.9 ± 3.50.03
Dichotomous (> 12 h)66 (5.0)1360 (4.5)0.38
MELD score at transplantation23.1 ± 9.122.6 ± 9.70.03
Table 2 Comparison of various outcomes on univariate analysis on waitlist and post liver transplant
TIPS on waitlist (n = 1366) % or mean ± SDNo TIPS on waitlist (n = 31417) % or mean ± SDP-values
Days on LT waitlist408 ± 552.6183 ± 330.5< 0.001
Mortality within 30 d46 (3.5)915 (3.0)0.344
Length of hospital stay17.58 ± 22.416.62 ± 22.10.118
Re-LT at 30 d15 (1.1)560 (1.8)0.06
Table 3 Multivariable logistic regression analysis to assess the impact of transjugular intrahepatic porto-systemic shunt on 30-d mortality after liver transplant
VariableOR (95%CI)P-values
TIPS1.26 (0.90-1.75)0.17
Male candidate0.83 (0.71-0.95)0.01
Candidate race
WhiteRef.
Black1.08 (0.85-1.37)0.54
Other1.08 (0.90-1.29)0.40
Diabetes mellitus1.12 (0.95-1.31)0.17
ALD0.89 (0.74-1.07)0.22
Hepatic encephalopathy
NoneRef.
Grade 1-20.86 (0.73-1.01)0.06
Grade 3-41.12 (0.85-1.47)0.41
Age1.02 (1.01-1.03)< 0.001
MELD score1.02 (1.00-1.04)0.05
Creatinine1.03 (0.97-1.10)0.33
Bilirubin1.01 (1.00-1.02)0.008
INR0.97 (0.86-1.09)0.59
Albumin0.88 (0.79-0.98)0.03
BMI1.00 (0.99-1.02)0.86
Cold ischemia time1.04 (1.02-1.05)< 0.001
Table 4 Multivariable logistic regression analysis to assess the impact of transjugular intrahepatic porto-systemic shunt on retransplantation
VariableOR (95%CI)P-values
TIPS0.61 (0.36-1.05)0.07
Male candidate1.02 (0.85-1.24)0.81
Candidate race
WhiteRef.
Black1.22 (0.91-1.64)0.18
Other1.05 (0.83-1.32)0.69
Diabetes mellitus0.98 (0.78-1.21)0.83
ALD0.98 (0.78-1.24)0.90
Hepatic encephalopathy
NoneRef.
Grade 1-20.92 (0.76-1.13)0.44
Grade 3-41.02 (0.69-1.51)0.91
Age0.97 (0.96-0.98)< 0.001
MELD score0.99 (0.97-1.02)0.51
Creatinine0.87 (0.77-0.99)0.03
Bilirubin0.99 (0.98-1.02)0.54
INR1.01 (0.86-1.18)0.9
Albumin1.03 (0.89-1.19)0.65
BMI1.005 (0.98-1.02)0.54
Cold ischemia time1.05 (1.03-1.07)< 0.001
Table 5 Ordinary least squares regression to assess the impact of transjugular intrahepatic porto-systemic shunt on length of hospital stay after liver transplant
Variableβ (95%CI)P-values
TIPS2.16 (0.92-3.38)0.001
Male candidate-1.99 (-2.52-1.46)< 0.001
Candidate race
WhiteRef.
Black-1.58 (-2.46-0.69)< 0.001
Other0.11 (-0.53-0.77)0.72
Diabetes mellitus0.52 (-0.05-1.10)0.07
ALD0.17 (-0.44-0.79)0.57
Hepatic encephalopathy
NoneRef.
Grade 1-2-0.10 (-0.66-0.46)0.73
Grade 3-43.46 (2.37-4.55)< 0.001
Age0.09 (0.06-0.11)< 0.001
MELD score0.37 (0.31-0.44)< 0.001
Creatinine0.05 (-0.21-0.31)0.71
Bilirubin0.03 (-0.008-0.08)0.1
INR-1.06 (-1.50-0.61)< 0.001
Albumin-0.63 (-1.01-0.24)0.001
BMI-0.05 (-0.100-0.01)0.01
Cold ischemia time0.36 (0.29-0.43)< 0.001
Constant7.83 (5.38-10.27)< 0.001