Improved Hepascore in hepatitis C predicts reversal in risk of adverse outcome

Table 1 Patient characteristics and outcomes

Characteristic	All patients		Patients with first Hepascore > 0.75		All patients		Patients with first Hepascore > 0.75
	Number	Percent	Number	Percent	mean	Range	mean	Range
Number	346	-	100	-	-	-	-	-
Gender (male)	220	63.6	76	76	-	-	-	-
SVR	38	11.0	16	16	-	-	-	-
Composite endpoint	28	8.1	21	21	-	-	-	-
LRD	8	2.3	8	8	-	-	-	-
LD	16	4.6	12	12	-	-	-	-
HCC	15	4.3	12	12	-	-	-	-
Result					-	-	-	-
Bilirubin (μmol/L)1	-	-	-	-	9.0	1.0-200	12	2.3-200
GGT (U/L)1	-	-	-	-	55.0	8.0-1005	93.5	17-713
HA (μg/L)1	-	-	-	-	30.3	1.0-1211	124.5	16-1211
A2M (μg/mL)1	-	-	-	-	2.5	0.6-6	3.6	1.5-6.0
Age (yr)	-	-	-	-	53.6	30-80	58.3	36-80
Baseline Hepascore	-	-	-	-	0.48	0.02-1.0	0.93	0.77-1.0
Second Hepascore	-	-	-	-	0.57	0.04-1.0	0.87	0.13-1.0
Delta Hepascore	-	-	-	-	0.09	-0.80-0.94	-0.06	-0.8-0.23
Time between baseline and second Hepascore (yr)	-	-	-	-	3.3	0.03-12.5	2.8	0.03-10.3
Follow-up after second Hepascore (yr)	-	-	-	-	2.2	0.01-7.3	1.9	0.01-5.7

¹Serum markers used in Hepascore calculation. GGT: Gamma glutamyl transpeptidase; HA: Hyaluronic acid; A2M: Alpha 2 macroglobulin.

Table 2 Predictors of composite clinical endpoint (liver related death, hepatocellular carcinoma, liver decompensation) using Multivariate Cox Regression

Variable	Follow-up from the baseline Hepascore		Follow-up from the second Hepascore
	P	Hazard ratio (95%CI)	P	Hazard ratio (95%CI)
Baseline Hepascore	< 0.001	5.85 (2.25-15.18)	0.020	12.86 (1.49-111.17)
Second Hepascore	-	-	0.891	3288.82 (0.0-4.6E + 53)
Delta Hepascore	-	-	0.013	4.77 (1.35-16.45)

Table 3 Predictors of survival using Kaplan-Meier survival curves

Test	End point	P value (log rank)	Cohort size
Baseline Hepascore alone	Composite Endpoint	< 0.001	346
	LRD	< 0.001	352
	LD	< 0.001	348
	HCC	< 0.001	350
Delta Hepascore	Composite Endpoint	0.004	96
	LRD	0.048	105
	LD	0.001	101
	HCC	0.178	100

LRD: Liver related death; LD: Liver decompensation; HCC: Hepatocellular carcinoma.

Table 4 Predictors of survival Using Area under Receiver Operating Characteristic

Test	End point	AUROC
Baseline Hepascore alone	Composite endpoint	0.80
	LRD	0.89
	LD	0.75
	HCC	0.87
Baseline Hepascore > 0.75 and Delta Hepascore	Composite endpoint	0.84
	LRD	0.95
	LD	0.77
	HCC	0.93

AUROC: Area under Receiver Operating Characteristic; LRD: Liver related death; LD: Liver decompensation; HCC: Hepatocellular carcinoma.