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Copyright ©The Author(s) 2016.
World J Hepatol. Mar 28, 2016; 8(9): 421-438
Published online Mar 28, 2016. doi: 10.4254/wjh.v8.i9.421
Table 1 Factors included in each staging system
Staging systemSizeNodulesMetPVTAFPCHAlbBilALPAscitesPS
TNMYesYesYesNoNoNoNoNoNoNoNo
OkudaYesNoNoNoNoNoYesYesNoYesNo
CLIPYesNoNoYesYesYesNoNoNoNoNo
FRENCHNoNoNoYesYesNoNoYesYesNoYes
BCLCYesYesYesYesNoYesNoYesNoNoYes
JISYesYesYesNoNoYesNoNoNoNoNo
CUPIYesYesYesNoYesNoNoYesYesYesNo
Table 2 Reported 5-year overall survival and recurrence in patients undergoing liver transplant for hepatocellular carcinoma within Milan criteria
Ref.n5-yr overall survival5-yr recurrence
Mazzaferro et al[155]4874%8%
Bismuth et al[149]4574%11%
Llovet et al[147]7975%4%
Jonas et al[151]12071%15%
Yao et al[158]6472%6.5%
Marsh et al[153]24867%3.6%
Herrero et al[154]4770%8.5%
Mazzaferro et al[155]44473%4.3%
Table 3 Summary of the characteristics of the published studies including patients within Milan criteria or with expanded criteria
Ref.Patients MC/ECHCC criteriaStaging methodDesign5-yr survival (%) MC/EC
Yao et al[158] UCSF criteria46/141 < 6 cmExplantRetro72
2-3 > 4, 5 cm
Sum diameter < 8 cm
Herrero et al[154] Navarra Criteria35/121 < 6 cmRxPros
2-3 < 5 cm
Kneteman et al[157]19/211 < 7.5 cmExplantPros87/83 (4-yr)
18/9Multinodular < 5 cmRx92/77
Yao et al[152]130/381 < 6 cmRxPros90/93
2-3 > 4, 5 cm
Sum diameter < 8 cm
Silva et al[159] Valencia Criteria231/261 < 5 cmExplantRetro62/69
254/272-3 < 5 cmRx
Sum diameter 10 cm
Herrero et al[156]59/261 < 6 cmExplantPros70/56
2-3 < 5 cmRx66/68
Mazzaferro et al[155] Metroticket444/283Sum nodules/sizeExplantRetro73/71
7 cm
Fan et al[160] Shanghai Criteria394/1761 < 9 cmExplantRetro51/65
2-3 < 5 cm
Sum diameter 9 cm
Guiteau et al[161]363/821 < 6 cmRxPros73/71 (3-yr)
2-3 < 5 cm
Sum diameter 9 cm