Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma

Table 1 List of polymorphic genes and their contribution to hepatocellular carcinoma

Polymorphism	Genotype	Significance	Ref.
COX-2	-1195G > A	P < 0.00[26]	He et al[31]
	-765G > C	P < 0.05[31] and 0.41[26]	Chen et al[26]
	+8473T > C	P = 0.83[26]
IL-1α, β	511C > T	P = 0.02[41]	Wang et al[41]
	-31C > T	P = 0.02[41]
CDH1	-347G > A	P = 0.171[209] and < 0.05[60]	Li et al[209], Chien et al[60]
PPARγ	L162V	P = 0.071[66]	Koytak et al[66]
TNFAIP3	F127C	P = 0.15[75]	Zhang et al[75]
TNFα	-1031T/C	P = 0.85[86]	Wei et al[86]
	-863C/A	P = 0.006[86]
	-857C/T	P = 0.09[86]
	-308G/A	P = 0.046[86]
	-238G/A	P = 0.003[86]
GST	GSTM1 + GSTT1	P = 0.001[210]	Liu et al[210]
EGF	+61A > G	P < 0.001[117]	Jiang et al[117]
MDM2	309G > T	P = 0.001[133]	Ezzikouri et al[133]
TIM3	-1516G > T	P = 0.001[146]	Li et al[146]
XPC	K939Q	P = 0.001[163]	Long et al[163]
1p36.22, 11q22.3, 6p21, 8p12 22q11.21	Include genes HLA-DQB2, HLA-DQA1, TCF19, HLA-C, UBE2L3, LTL, FDX1, MICA, UBE4B and PG	P = 1.7 × 10-18	Al-Qahtani et al[181]
		P = 4.3 × 10-8
		P = 0.0266
		P = 0.0067
		P = 1.71 × 10-12
TGFβ1	-509C > T	P = 0.01[206] and 0.318[207]	Qi et al[206]
	R25P	P = 0.472[207]	Hosseini Razavi et al[207]
	L10P	P < 0.02[208]	Kim et al[208]

COX-2: Cyclooxygenase-2; IL-1α, β: Interleukin-1α, β; CDH1: Cadherin 1; PPARγ: Peroxisome proliferator-activated receptor γ; TNFAIP3: Tumor necrosis factor alpha-induced protein 3; TNFα: Tumor necrosis factor α; GST: Glutathione S transferase; EGF: Epidermal growth factor; MDM2: Mouse double minute 2 homolog; TIM3: T-cell immunoglobulin 3; XPC: Xeroderma pigmentosum; TGFβ1: Transforming growth factor beta 1.