Anticoagulation and antiplatelets as prophylaxis for hepatic artery thrombosis after liver transplantation

Table 1 Risk factors of hepatic artery thrombosis

Operative factors	Non operative factors
Surgical technique	Donor age of more than 60 yr
Number of anastomosis	Long cold ischemia time
Use of conduits	Preservation damage
Vessels kinking	Lack of blood group compatibility
Small vessels size	Cytomegalovirus-positive donor status
	Hypercoagulable recipient status
	Recipient cigarette smoking
	Rejection
	Primary sclerosing cholangitis

Table 2 Factors involved in development of hypercoagulability after liver transplantation

Endogenous	Acquired
Substantial surgical damage	Donor with factor V Leiden mutation
Stasis as a result of clamping of major vessels	Infections
Release of activators from the donor liver	Viral infection like cytomegalovirus
Systemic inflammatory responses	Perioperative haemostatic agent
The quality of the graft	Fresh frozen plasma
The length of surgery	Platelets
The technique of graft preservation	Recombinant factor VIIa
Cold ischemia/reperfusion effect	Anti-fibrinolytics
	Aprotinin Aminocaproic acid