Monoclonal antibodies: Principles and applications of immmunodiagnosis and immunotherapy for hepatitis C virus

Table 1 Hepatitis C virus neutralizing antibodies

Neutralizing antibody	Epitope	Specificity	Escape mutants	Ref.
IGH505	E1 (313-326) linear	Cross-reactive	NA	[27]
IGH526	E1 (313-326) linear	Cross-reactive	NA	[27]
H-111	E1 (192-202) linear	Cross-reactive	NA	[68]
95-2	E2 (412-423) linear	Cross-reactive	NA	[65]
HCV-1	E2 (412-423) linear	Cross-reactive	NA	[65]
HC-1	E2 (523-540) conformational	Cross-reactive	No escape	[69,125]
3/11	E2 (412-423) linear	Cross-reactive	N415Y, N415D, N417S, G418D	[75]
3C7	E2 (396-407)	H strain	NA	[126]
AP33	E2 (412-423) linear	Cross-reactive	N415Y, N415D, N417S, G418D	[75]
CBH7	E2 conformational	Cross-reactive	NA	[74]
CBH5	E2 (523-540) conformational	Cross-reactive	NA	[68,127]
CBH2	E2 (425-447), E2 (523-540) conformational	Cross-reactive	D431G, A439E	[68,125,128]
CBH-8C	E2 conformational	Cross-reactive	NA	[129]
CBH-8E	E2 conformational	Cross-reactive	NA	[129]
CBH-11	E2 conformational	Cross-reactive	NA	[129]
CBH-17	E2 conformational	Cross-reactive	NA	[129]
CBH4B	E2 conformational	Cross-reactive	NA	[129]
CBH4D	E2 conformational	Cross-reactive	NA	[129]
CBH4G	E2 conformational	Cross-reactive	NA	[129]
9/27	E2 conformational	H strain	NA	[130]
A8	E2 (523-540) conformational	Cross-reactive	NA	[127]
J6.36	E2 Partially conformational	J6 strain	NA	[131]
HC-11	E2 (425-447)	NA	L438F	[69,125]
	E2 (523-540) conformational
Fab e20	E2 (523-540) conformational	Cross-reactive	NA	[132]
Fab e137	E2 (412-423)	Cross-reactive	NA	[73]
	E2 (523-540) conformational
1:7	E2 (523-540) conformational	Cross-reactive	NA	[127]
AR3A	E2 (394-424), E2 (437-447)	Cross-reactive	NA	[76]
	E2 (523-540) conformational
AR3B	E2 (394-424)	Cross-reactive	NA	[76]
	E2 (437-447)
	E2(523-540) conformational
AR3C	E2 (394-424), E2(437-447)	Cross-reactive	NA	[76]
	E2 (523-540) conformational
AR3D	E2 (394-424), E2 (437-447)	Cross-reactive	NA	[76]
	E2 (523-540) conformational
AP213	E2 (396-407) partially conformational	Gla strain	NA	[133]
H77.39	E2 (384-520) linear	Cross-reactive	NA	[131]
H35	E2-conformational	Poorly cross-reactive	NA	[134]
H48	E2-conformational	Poorly cross-reactive	NA	[134]
2/69a	E2 (436-443) linear	NA	NA	[135]
9/86a	E2 conformational	NA	NA	[130]
6/1a	E2 (464-471) linear	NA	NA	[130]
9/75	E2 (524-531) linear	NA	NA	[130]
6/53	E2 (544-551) linear	NA	NA	[130]
6/16	E2 (384-391) linear	NA	NA	[130]
1/39	E2 (432-443) linear	NA	NA	[130]
6/41a	E2 (480-493) linear	NA	NA	[130]
11/20c	E2 (436-447) linear	NA	NA	[130]
ALP98	E2 (644-651) linear	Cross-reactive	NA	[136]
ALP1	E2 (647-658) linear	NA	NA	[136]

NA: Not available.