Severe immune thrombocytopenia after peg-interferon-alpha2a, ribavirin and telaprevir treatment completion: A case report and systematic review of literature

Table 1 Literature review and summary of all published cases of interferon-induced autoimmune thrombocytopenia for hepatitis C virus infection

Ref.	Sex	Age	HCV genotype	Antiviral therapy	Occurrence of AITP	Clinical outcome
de Manuel Moreno et al[5]	F	46	1b	Peg-IFNα-2b + RBV	12 wk	Corticosteroids responsive
Kim et al[6]	F	72	NR	Peg-IFNα-2a	120 wk	Corticosteroids responsive
Li et al[26]	F	54	1b	Peg-IFNα-2a + RBV	12 wk	CR
Elefsiniotis et al[16]	M	27	NR	Peg-IFNα-2b + RBV	24 wk after therapy discontinuation	CR
Huang et al[7]	F	48	2	Peg-IFNα-2a + RBV	1 wk	Corticosteroids responsive
Naz et al[8]	F	60	NR	Peg-IFNα-2b + RBV	7 wk	CR (treated with ursodeoxycholic acid)
Enomoto et al[9]	F	69	1b	Peg-IFNα-2b + RBV	12 wk	Corticosteroids responsive
Carnero-Fernández et al[10]	M	20	NR	Peg-IFNα-2b + RBV	20 wk	CR (treated with iv immunoglobulin )
Alves Couto et al[11]	M	44	NR	Peg-IFNα-2b + RBV	16 wk	CR
Weitz et al[12]	F	43	1b	Peg-INF + RBV	48 wk	CR (treated with Rituximab)
Lambotte et al[24]	F	73	1b	Peg-IFNα-2a + RBV	8 wk	CR
Nakajima et al[23]	M	47	1b	IFNα-2a + RBV	8 wk	Incomplete response
Medeiros et al[13]	M	40	NR	IFN-α + RBV (for 24 wk) and Peg-IFNα-2a + RBV	36 wk	CR
Dimitroulopoulos et al[22]	F	20	3	IFNα	28 wk	CR
Sevastianos et al[14]	F	38	4	Peg-IFNα-2b	4 wk	CR
Fujii et al[21]	F	24	NR	IFNα	4 wk	CR
Sagir et al[15]	M	45	NR	Peg-IFNα-2b + RBV	10 wk	CR
Pockros et al[20]	M	61	1b	IFNα	16 wk	CR
Jiménez-Sáenz et al[19]	M	46	NR	IFNα-2b	144 wk	CR
Tappero et al[18]	F	NR	NR	IFNα-2a	8 wk	CR
Dourakis et al[25]	M	39	NR	IFNα	32 wk	CR
Dourakis et al[25]	F	64	NR	IFNα	24 wk	CR
Shrestha et al[17]	M	41	NR	IFNα	NR	CR
Demirturk et al[27]	NR	NR	NR	Peg-IFN + RBV	NR	CR

CR: Completely resolved; NR: Not reported; HCV: Hepatitis C virus; IFN: Interferon; Peg-IFN: Pegylated-IFN; AITP: Autoimmune thrombocytopenia; RBV: Ribavirin; iv: Intravenous.