Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience

Table 1 Genes frequently mutated in hepatocellular carcinoma

Gene	Pathways/gene functions involved	Ref.
p53	Genome integrity and cell cycle	Clearly et al[7]
CTNNB1	Wnt/β-catenin signaling	Kan et al[9]
ARID1A	Chromatin remodeling	Fujimoto et al[8]
mTOR	PI3K/AKT/mTOR	Riechle et al[20]
NFE2L2	Oxidative/ER stress	Guichard et al[16]
TERT promoter	Telomere stability	Nault et al[183]

PI3K/AKT/mTOR: Phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin.

Table 2 Liver imaging reporting and data system categories

LI-RADS category	Significance
1	Definitely benign
2	Probably benign
3	Indeterminate
4	Probably HCC
5	Definitely HCC

LI-RADS: Liver imaging reporting and data system; HCC: Hepatocellular carcinoma.