Role of hepatectomy for recurrent or initially unresectable hepatocellular carcinoma

Table 1 Repeat resection rate, 5-year recurrence-free survival rate, and overall survival rate after repeat hepatectomy in previous studies

Ref.	Year	Number of primary hepatectomy	Number of second hepatectomy/HCC recurrence after primary hepatectomy	5-yr recurrence free survival after repeat hepatectomy	5-yr overall survival after repeat hepatectomy
Poon et al[4]	1999	244	11/105 (10%)	NA	69%
Nakajima et al[7]	2001	94	12/57 (21%)	Not reached	52%
Sugimachi et al[8]	2001	474	78/300 (26%)	NA	47.50%
Minagawa et al[9]	2003	334	56/183 (31%)	17%	56%
Chen et al[5]	2004	627	34/286 (12%)	NA	56.80%
Taura et al[10]	2006	610	55/465 (12%)	NA	NA
Itamoto et al[11]	2007	483	70/279 (25%)	10%	50%
Shimada et al[12]	2007	319	13/211 (6%)	NA	25%
Tralhão et al[6]	2007	190	16/97 (19%)	NA	31%
Liang et al[13]	2008	NA	73/853 (9%)	10.50%	27.60%
Choi et al[14]	2008	353	9/97 (9%)	NA	78%
Wu et al[15]	2009	1177	149/641(23%)	31.80%	56.40%
Kishi et al[16]	2011	221	8/134 (6%)	NA	37.50%
Huang et al[17]	2012	NA	82/NA	8.20%	22.40%
Tsujita et al[18]	2012	NA	112/NA	NA	67.30%
Yamashita et al[19]	2013	791	163/308 (53%)	29%	60%

HCC: Hepatocellular carcinoma; NA: Not assessed.

Table 2 Three types of definition of intrahepatic metastases by the Liver Cancer Study Group of Japan[21]

	Definition
1	Tumors clearly growing from portal vein tumor thrombi
2	Tumors surrounding a large main tumor with multiple satellite nodules
3	A small solitary tumor that is near the main tumor and histologically similar to or less differentiated than the main tumor