Human immunodeficiency virus and nodular regenerative hyperplasia of liver: A systematic review

Table 1 Literature review of nodular regenerative hyperplasia in human immunodeficiency virus positive patients (biopsy confirmed)

Ref.	Study type	Number of patients	Clinical presentation
Arey et al[21]	Case report	1	Abdominal distention, abdominal, pain, EV
Bihl et al[31]	Case report	1	Abdominal pain, ALP, ascites, EV, GIB, splenomegaly
Bissonnette et al[11]	Case report	2	Ascites, EV, GIB
Cachay et al[15]	Case series	1	ALP
Saifee et al[52]	Case series	11	Ascites, EV, GIB
Cesari et al[53]	Case control	5	Ascites, EV, GIB, splenomegaly
Cotte et al[12]	Case control	13	Abdominal pain, ALP, ascites, EV, GIB, splenomegaly
Alvarez Díaz et al[33]	Case report	2	ALP, ascites, EV, GIB
Ding et al[54]	Case report	1	ALP, EV, GIB, ascites
Dinh et al[55]	Case control	3	Ascites, encephalopathy, EV
Fernandez-Miranda et al[9]	Case report	1	Unknown
Garvey et al[19]	Case report	2	EV, splenomegaly
Hofmaenner et al[27]	Case report	1	Epigastric pain, ALP
Kochin et al[56]	Case report	1	EV, GIB
Kovari et al[23]	Case control	1	EV
Maida et al[8]	Case series	2	Splenomegaly
Mallet et al[4]	Case control	13	ALP, EV, GIB
Mallet et al[57]	Case report	1	Portal hypertension
Mallet et al[30]	Case series	8	ALP, ascites, EV, splenomegaly
Mendizabal et al[58]	Case control	5	EV, GIB
Podevin et al[59]	Case report	1	Ascites, EV, splenomegaly
Sandrine et al[20]	Case report	1	ALP, ascites, EV, splenomegaly
Santiago et al[28]	Case report	1	Abdominal distention, splenomegaly
Schiano et al[22]	Case report	1	ALP, EV, splenomegaly
Scourfield et al[60]	Retrospective cohort	4	Unknown
Schouten et al[61]	Case report	3	EV, GIB
Stebbing et al[62]	Retrospective cohort	2	ALP
Tateo et al[13]	Case report	3	ALP, ascites, EV, GIB
Vispo et al[29]	Case report	3	ALP, ascites, EV, GIB

ALP: Abnormal liver panel; EV: Esophageal varices; GIB: Gastrointestinal bleed.

Table 2 Manifestations of portal hypertension in patients with nodular regenerative hyperplasia and human immunodeficiency virus n (%)

Manifestation	Patients identified	References
Ascites	30 (32)	[4,12,19,20,28,33,52,53,58,60]
Esophageal varices	61 (66)	[4,12,19,20,28,33,52,53,58,60]
Hepatic encephalopathy	1 (1.1)	[54]
Splenomegaly	25 (27)	[4,12,19,20,31,52,53,54,58,60]
Portal thrombosis	11 (12)	[4,12,19,20,31,52,53,54,58]

Table 3 Select laboratory tests associated with nodular regenerative hyperplasia

Laboratory test	Range	References
Albumin (g/dL)	1.9-4.5	[22,28,52,54,55]
Aspartate transaminase (IU/L)	15-139	[4,8,20-22,30,31,38,54,55,59,60]
Alanine transaminase (IU/L)	13-196	[3,7,19-21,30,31,52,54,55,59,60]
Alkaline Phosphatase (IU/L)	92-541	[4,20-23,28,31,52,53,55,59,60]
Total bilrubin (mg/dL)	0.6-3.6	[21,22,31,52,54,55,59,60]
Gamma glutamyl transpeptidase (IU/L)	12-771	[4,20,22,28,31,53,55,59,60]
White blood cell count (cells/mm3)	1090-4800	[4,21,22,28,30,31,33,53-55,60]
Hemoglobin (g/dL)	6.6-13	[22,55,60]
Platelet (1000/mm3)	61-273	[4,22,23,52,54,55,59,60]