Differential expression of hepatic apurinic/apyrimidinic endonuclease 1, a DNA repair enzyme, in chronic hepatitis

Table 1 Clinical characteristics in patients with chronic liver disease

Characteristics	HCV (n = 30)	HBV (n = 27)	AIH (n = 6)	PBC (n = 6)	HCV vs HBV
Gender (male/female)	18/12	18/9	0/6	1/5	NS
Age (yr)	56.8 ± 9.1 (39-73)	52.6 ± 12.9 (22-69)	58.5 ± 12.2 (47-74)	56.3 ± 7.0 (44-64)	NS
Platelet count (× 104/mm3)	15.7 ± 5.9 (9.3-32.3)	14.6 ± 6.2 (8.2-28.4)	14.9 ± 7.6 (12.7-26.0)	16.0 ± 4.4 (13.4-23.6)	NS
AST (IU/L)	55 ± 36 (13-191)	135 ± 84 (59-341)	118 ± 32 (47-120)	32 ± 6 (21-35)	P < 0.001
ALT (IU/L)	71 ± 60 (16-307)	180 ± 153 (79-554)	138 ± 37 (54-144)	45 ± 18 (11-53)	P < 0.001
γGTP (IU/L)	45 ± 36 (14-175)	84 ± 43 (41-135)	147 ± 53 (35-228)	114 ± 63 (23-179)	P < 0.01
Viral load	> 500 KIU/mL (n = 16)
	100-500 KIU/mL (n = 4)	> 7.6 log copies/mL (n = 11)
	< 100 KIU/mL (n = 10)	≤ 7.6 log copies/mL (n = 16)
Liver histopathology				Ludwig’s stage
Necroinflammation (mild/moderate/severe)	5/20/5	7/15/5	2/3/1	Portal stage (n = 2)	NS
				Periportal stage (n = 4)
Fibrosis (none/mild/moderate/severe/cirrhosis)	0/17/8/4/1	3/10/8/4/2	1/4/1/0/0	Septal stage (n = 0)
				Cirrhotic stage (n = 0)	NS

Values represent mean ± SE unless otherwise stated. HCV: Hepatitis C virus; HBV: Hepatitis B virus; AIH: Autoimmune hepatitis; PBC: Primary biliary cirrhosis; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; γGTP: γ glutamyl transpeptidase.