Centrilobular necrosis in acute presentation of Japanese patients with type 1 autoimmune hepatitis

Table 1 Clinicopathological data of patients with autoimmune hepatitiswith and without centrilobular necrosis n (%)

Abbreviations (normal values)	With CN (n = 13)	Without CN (n = 28)	P value
Mean age (range) (yr)	51.1 (23-80)	52.7 (21-77)	NS
Sex (M/F)	2/11	1/27	NS
ALT (IU/L)	907 (228-3250)	667 (224-1761)	NS
ALP (IU/L)	498 (223-999)	450 (76-883)	NS
IgG (mg/dL)	2307 (1150-3913)	3126 (1294-5449)	< 0.05
ANA neg.	4 (30.7)	1 (3.5)	< 0.05
Other autoimmune disease	4 (30.7)	7 (25.0)	NS
Steroid therapy	11 (84.6)	24 (85.7)	NS
Azathioprine therapy	2 (15.4)	7 (25.0)	NS
AIH score original	12 (6-20)	14 (6-18)	NS
(Median) simplified	6 (3-8)	7 (5-8)	< 0.05
Interface hepatitis	10 (76.9)	26 (92.8)	NS
Portal inflammation	13 (100)	24 (85.7)	NS
Plasma cell infiltration	7 (53.8)	7 (25.0)	NS
Rosette formation	3 (23.1)	3 (12.0)	NS
Fibrosis
Stage F0-2	11 (84.6)	10 (35.7)	< 0.05
Stage F3-4	2 (15.4)	18 (64.3)

ALT: Alanineaminotransferase (8-42 IU/L); ALP: Alkaline phosphatase (115-359 IU/L); IgG: Immunoglobulin G (870-1700 mg/dL); ANA: Antinuclear antibody (< 40 ×); NS: Not significant; AIH: Autoimmune hepatitis; CN: Centrilobular necrosis. P values were calculated using the Mann-Whitney U test and the χ² test.

Table 2 Clinical and serological features of 13 autoimmune hepatitis patients with centrilobular necrosis

Case	Age (yr)/sex	ALT (IU/L)	ALP (IU/L)	IgG (mg/dL)	ANA (titer)	ASMA (titer)	AIH score		HLA	Histology
							(O)	(S)	DR4	(I)	(L)	(R)	(E)	(F)
1	56/F	831	357	3330	5120	40	20	8	DR4	+	+	+	+	3
2	68/F	1230	479	3215	640	Neg	11	7	-	+	+	+	-	3
3	45/F	3250	423	1800	160	Neg	14	6	DR4	+	+	-	-	2
4	49/M	713	528	2300	640	40	15	7	DR4	+	+	+	-	1
5	23/F	789	596	3913	160	640	17	7	DR4	+	+	-	-	1
6	42/M	1499	972	1150	Neg	Neg	9	3	DR4	-	+	-	-	1
7	57/F	471	223	2266	Neg	20	6	3	DR4	+	+	-	-	1
8	80/F	499	410	1410	40	Neg	11	4	-	+	+	-	-	1
9	52/F	416	458	1280	Neg	160	11	5	-	-	+	-	-	1
10	44/F	1067	377	1370	Neg	Neg	6	3	DR4	-	+	+	-	1
11	44/F	418	273	3503	2560	Neg	14	7	-	+	+	-	-	2
12	35/F	383	335	3086	160	80	17	7	ND	+	+	-	-	1
13	69/F	228	999	1286	160	Neg	13	5	-	+	+	-	-	2

Abbreviations (normal values): ALT: Alanine aminotransferase (8-42 IU/L); ALP: Alkaline phosphatase (115-359 IU/L); IgG: Immunoglobulin G (870-1700 mg/dL); ANA: Antinuclear antibody (< 40 ×); ASMA: Anti-smooth muscle antibody (negative); O: Original system; S: Simplified system; I: Interface hepatitis; L: Lymphocytic/lymphoplasmocytic infiltrates in portal tracts; R: Rosette formation; E: Emperipolesis; F: Fibrosis; Neg: Negative; ND: Not detected; F: Female; M: Male; AIH: Autoimmune hepatitis.