Aizawa N, Enomoto H, Imanishi H, Saito M, Iwata Y, Tanaka H, Ikeda N, Sakai Y, Takashima T, Iwai T, Moriwaki EI, Shimomura S, Iijima H, Nakamura H, Nishiguchi S. Elevation of the glycated albumin to glycated hemoglobin ratio during the progression of hepatitis C virus related liver fibrosis. World J Hepatol 2012; 4(1): 11-17 [PMID: 22312451 DOI: 10.4254/wjh.v4.i1.11]
Corresponding Author of This Article
Hirayuki Enomoto, MD, PhD, Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan. enomoto@hyo-med.ac.jp
Article-Type of This Article
Brief Article
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World J Hepatol. Jan 27, 2012; 4(1): 11-17 Published online Jan 27, 2012. doi: 10.4254/wjh.v4.i1.11
Table 1 Characteristics of the patients
Age (yr)
60 (19-78)
Gender (male/female)
60/82
AST (IU/L)
37.5 (14-328)
ALT (IU/L)
36 (10-388)
γ-GTP (IU/L)
29 ( 7-259)
ALP (IU/L)
217 ( 97-556)
Total bilirubin (mg/dL)
0.7 (0.1-2.1)
Albumin (g/dL)
3.96 ± 0.36
Hemoglobin (g/dL)
13.4 ± 1.8
Platelet (× 104/mm3)
15.9 ± 5.5
PT-INR
1.04 ± 0.07
Table 2 Characteristics of the patients (F0-F3 vs F4), (F0-F2 vs F3-F4) and (F0-F1 vs F2-F4)
F0-F3(n = 115)
F4(n = 27)
P value
F0-F2(n = 86)
F3-F4(n = 56)
P value
F0-F1(n = 61)
F2-F4(n = 81)
P value
Age (yr)
60 (19-78)
62 (23-78)
NS
60 (19-78)
62 (23-78)
NS
60 (19-78)
62 (23-78)
NS
Gender (male/female)
48/67
12/15
NS
31/55
29/37
NS
25/36
35/46
NS
AST (IU/L)
35 (14-195)
50 (20-328)
< 0.001
32 (14-175)
46 (20-328)
< 0.001
32 (14-104)
42 (18-328)
< 0.001
ALT (IU/L)
38 (10-388)
47 (10-310)
< 0.05
31.5 (10-388)
48 (10-310)
< 0.01
31 (11-388)
46 (10-310)
< 0.01
γ-GTP (IU/L)
25 ( 7-183)
50 (12-259)
< 0.001
22 ( 7-183)
42.5 (12-259)
< 0.0001
22 ( 8-183)
36 ( 7-259)
< 0.01
ALP (IU/L)
207 ( 97-490)
267 (133-556)
< 0.001
186 (97-465)
275 (133-556)
< 0.0001
207 ( 97-465)
258 (101-556)
< 0.001
Total bilirubin (mg/dL)
0.7 (0.1-1.6)
0.7 (0.3-2.1)
NS
0.7 (0.1-1.6)
0.8 (0.3-2.1)
NS
0.7 (0.1-1.6)
0.7 (0.3-2.1)
NS
Albumin (g/dL)
4.02 ± 0.31
3.70 ± 0.43
< 0.001
4.03 ± 0.32
3.84 ± 0.37
< 0.01
4.05 ± 0.31
3.89 ± 0.38
< 0.01
Hemoglobin (g/dL)
13.5 ± 1.7
12.8 ± 2.0
NS
13.5 ± 1.8
13.3 ± 1.7
NS
13.7 ± 1.7
13.2 ± 1.8
NS
Platelet (× 104/mm3)
16.5 ± 5.3
13.2 ± 5.9
< 0.001
17.2 ± 5.2
13.8 ± 5.5
< 0.001
17.2 ± 4.8
14.9 ± 5.9
< 0.05
PT-INR
1.03 ± 0.05
1.08 ± 0.06
< 0.001
1.02 ± 0.05
1.07 ± 0.06
< 0.001
1.02 ± 0.05
1.05 ± 0.08
< 0.05
Table 3 Glycated albumin/glycated hemoglobin ratio for the detection of cirrhosis (F4), severe fibrosis (F3-F4) and significant fibrosis (F2-F4) (%)
F4
F0-F3
F3-F4
F0-F2
F2-F4
F0-F1
GA/HbA1c > 3.0
16/27 (59.3)
34/115 (29.6)
28/56 (50.0)
22/86 (25.6)
36/81 (44.4)
14/61 (23.0)
GA/HbA1c ≤ 3.0
11/27 (40.7)
81/115 (70.4)
28/56 (50.0)
64/86 (74.4)
45/81 (55.6)
47/61 (77.0)
Table 4 Aspartate aminotransferase-to-platelet ratio index for the detection of significant liver fibrosis (F2-F4)
F2-F4 (%)
F0-F1 (%)
F2-F4 (%)
F0-F1 (%)
APRI > 0.5
68/81 (84.0)
32/61 (52.5)
APRI > 1.5
21/81 (25.9)
6/61 (9.8)
APRI ≤ 0.5
13/81 (16.0)
29/61 (47.5)
APRI ≤ 1.5
60/81 (74.1)
55/61 (90.2)
Table 5 Combination of aspartate aminotransferase-to-platelet ratio index and glycated albumin/glycated hemoglobin ratio for the detection of significant liver fibrosis (F2-F4)
F2-F4 (%)
F0-F1 (%)
F2-F4 (%)
F0-F1 (%)
APRI > 1.5 or GA/HbA1c > 3.0
43/81 (53.1)
18/61 (29.5)
APRI > 1.5 or GA/HbA1c > 3.2
34/81 (42.0)
10/61 (16.4)
Others
38/81 (46.9)
43/61 (70.5)
Others
47/81 (58.0)
51/61 (83.6)
Citation: Aizawa N, Enomoto H, Imanishi H, Saito M, Iwata Y, Tanaka H, Ikeda N, Sakai Y, Takashima T, Iwai T, Moriwaki EI, Shimomura S, Iijima H, Nakamura H, Nishiguchi S. Elevation of the glycated albumin to glycated hemoglobin ratio during the progression of hepatitis C virus related liver fibrosis. World J Hepatol 2012; 4(1): 11-17