Brief Article
Copyright ©2012 Baishideng Publishing Group Co.
World J Hepatol. Jan 27, 2012; 4(1): 11-17
Published online Jan 27, 2012. doi: 10.4254/wjh.v4.i1.11
Table 1 Characteristics of the patients
Age (yr)60 (19-78)
Gender (male/female)60/82
AST (IU/L)37.5 (14-328)
ALT (IU/L)36 (10-388)
γ-GTP (IU/L)29 ( 7-259)
ALP (IU/L)217 ( 97-556)
Total bilirubin (mg/dL)0.7 (0.1-2.1)
Albumin (g/dL)3.96 ± 0.36
Hemoglobin (g/dL)13.4 ± 1.8
Platelet (× 104/mm3)15.9 ± 5.5
PT-INR1.04 ± 0.07
Table 2 Characteristics of the patients (F0-F3 vs F4), (F0-F2 vs F3-F4) and (F0-F1 vs F2-F4)
F0-F3(n = 115)F4(n = 27)P valueF0-F2(n = 86)F3-F4(n = 56)P valueF0-F1(n = 61)F2-F4(n = 81)P value
Age (yr)60 (19-78)62 (23-78)NS60 (19-78)62 (23-78)NS60 (19-78)62 (23-78)NS
Gender (male/female)48/6712/15NS31/5529/37NS25/3635/46NS
AST (IU/L)35 (14-195)50 (20-328)< 0.00132 (14-175)46 (20-328)< 0.00132 (14-104)42 (18-328)< 0.001
ALT (IU/L)38 (10-388)47 (10-310)< 0.0531.5 (10-388)48 (10-310)< 0.0131 (11-388)46 (10-310)< 0.01
γ-GTP (IU/L)25 ( 7-183)50 (12-259)< 0.00122 ( 7-183)42.5 (12-259)< 0.000122 ( 8-183)36 ( 7-259)< 0.01
ALP (IU/L)207 ( 97-490)267 (133-556)< 0.001186 (97-465)275 (133-556)< 0.0001207 ( 97-465)258 (101-556)< 0.001
Total bilirubin (mg/dL)0.7 (0.1-1.6)0.7 (0.3-2.1)NS0.7 (0.1-1.6)0.8 (0.3-2.1)NS0.7 (0.1-1.6)0.7 (0.3-2.1)NS
Albumin (g/dL)4.02 ± 0.313.70 ± 0.43< 0.0014.03 ± 0.323.84 ± 0.37< 0.014.05 ± 0.313.89 ± 0.38< 0.01
Hemoglobin (g/dL)13.5 ± 1.712.8 ± 2.0NS13.5 ± 1.813.3 ± 1.7NS13.7 ± 1.713.2 ± 1.8NS
Platelet (× 104/mm3)16.5 ± 5.313.2 ± 5.9< 0.00117.2 ± 5.213.8 ± 5.5< 0.00117.2 ± 4.814.9 ± 5.9< 0.05
PT-INR1.03 ± 0.051.08 ± 0.06< 0.0011.02 ± 0.051.07 ± 0.06< 0.0011.02 ± 0.051.05 ± 0.08< 0.05
Table 3 Glycated albumin/glycated hemoglobin ratio for the detection of cirrhosis (F4), severe fibrosis (F3-F4) and significant fibrosis (F2-F4) (%)
F4F0-F3F3-F4F0-F2F2-F4F0-F1
GA/HbA1c > 3.016/27 (59.3)34/115 (29.6)28/56 (50.0)22/86 (25.6)36/81 (44.4)14/61 (23.0)
GA/HbA1c ≤ 3.011/27 (40.7)81/115 (70.4)28/56 (50.0)64/86 (74.4)45/81 (55.6)47/61 (77.0)
Table 4 Aspartate aminotransferase-to-platelet ratio index for the detection of significant liver fibrosis (F2-F4)
F2-F4 (%)F0-F1 (%)F2-F4 (%)F0-F1 (%)
APRI > 0.568/81 (84.0)32/61 (52.5)APRI > 1.521/81 (25.9)6/61 (9.8)
APRI ≤ 0.513/81 (16.0)29/61 (47.5)APRI ≤ 1.560/81 (74.1)55/61 (90.2)
Table 5 Combination of aspartate aminotransferase-to-platelet ratio index and glycated albumin/glycated hemoglobin ratio for the detection of significant liver fibrosis (F2-F4)
F2-F4 (%)F0-F1 (%)F2-F4 (%)F0-F1 (%)
APRI > 1.5 or GA/HbA1c > 3.043/81 (53.1)18/61 (29.5)APRI > 1.5 or GA/HbA1c > 3.234/81 (42.0)10/61 (16.4)
Others38/81 (46.9)43/61 (70.5)Others47/81 (58.0)51/61 (83.6)