Outcome after liver transplantation: Predicting the unpredictable

Table 1 summary of studies evaluating the performance of Charlson Comorbidity index in liver transplantation

Ref.	Number of patients included	Type of study	Primary outcome	Median age at transplant (year)	LDLT/DDLT recipients	Score	Main findings
Volk et al[19]	624	Retrospective	Long-term mortality (1 year and 5 years)	51	DDLT	CCI; CCI-OLT	CCI-OLT is useful in predicting post-LT long-term survival
Raszeja-Wyszomirska et al[23]	48	Retrospective	Short-term mortality (1 month)	51	DDLT	CPT + Crea; CPT + Na; MELD; MESO	CPT-Crea is a good predictor of 1-month mortality after LT
Wasilewicz et al[31]	197	Retrospective	Short-term mortality (1 month)	50	DDLT	CCI-OLT	CCI-OLT is a valuable predictor of long-term survival after OLT, but its prognostic power is reduced in predicting 1-month survival
Grosso et al[32]	221	Retrospective	Long-term mortality (1 year)	52	DDLT and LDLT	CCI	CCI is significantly associated with post-LT outcomes
Alim et al[37]	951	Retrospective	Long-term mortality (1 year)	63	LDLT	CCI	CCI is useful in predicting survival after 12 months post-LDLT in patients older than 60 years
Niewiński et al[38]	248	Retrospective	Short and long-term mortality (90 days and 5 years)	54	DDLT	CCI-OLT	CCI-OLT is a good prognostic score to assess post-LT survival. Age and diabetes are the main components of CCI able to affect 90-day mortality post-OLT while metabolic and vascular disease are risk factors for 5-year mortality
Choi et al[39]	155	Retrospective	Short and long-term mortality (1 month and 3 months, 1 year, 3 years and 5 years)	69	DDLT and LDLT	CCI-OLT; CPT; MELD; mFI-5	CCI-OLT and MELD are more accurate than CPT and mFI-5 in predicting post-LT survival

LDLT: Living donor liver transplantation; DDLT: Deceased donor liver transplantation; CCI: Charlson Comorbidity Index; OLT: Orthotopic liver transplantation; CPT: Child-Pugh-Turcotte; Crea: Creatinine; Na: Sodium; MELD: Model for end stage liver disease; MESO: Model for end stage liver disease-to-serum sodium ratio; mFI-5: Modified-frailty index-5; LT: Liver transplantation.