Educational video module for increasing treatment rates for alcohol use disorders in inpatients

Table 1 Evaluation of methodological limitations and recommendations

Domain	Limitations of the current study	Recommendations for improvement
Trial design	Two-arm (EVM + brief intervention vs retrospective control), unable to isolate the effect of EVM	Three-arm RCT: (1) EVM + brief intervention + order set; (2) Brief intervention + order set only; and (3) Usual care. Minimum follow-up of 12 months
Sample size	n = 42 intervention, no published power calculation	A priori sample size calculation to detect a 15% difference in the primary outcome with 80% power, P value = 0.05
Outcome measures	Self-reported alcohol use without consistent biomarker validation; no histology	Primary outcome: Composite of validated biomarkers (CDT, PEth) + structured clinical assessment (AUDIT score). Secondary: Liver stiffness measurement via FibroScan to track disease progression
Adherence monitoring	No data on EVM completion rate or medication adherence	(1) Video analytics to track completion; (2) Pill counts or pharmacy refill data; and (3) Knowledge assessment pre-post EVM using validated instrument
Population	74% female, single center, United States/Spain only	Balanced sex distribution, multicenter design including community hospitals, multilingual EVM
Statistical analysis	Retrospective control with demographic imbalance	Concurrent randomization with stratification by disease severity (MELD score) and prior treatment history

AUDIT: Alcohol use disorders identification test; RCT: Randomized controlled trial; CDT: Carbohydrate-deficient transferrin; EVM: Educational video module; MELD: Model for end-stage liver disease; PEth: Phosphatidylethanol.