Patient factors in responders and non-responders treated with steroids for acute alcohol-associated hepatitis

Table 1 Pre-steroid patient factors and response to steroid, n (%)

Pre-steroid factors	Nonresponse (n = 36)1	Response (n = 16)1	P value
PEth (continuous) (ng/mL)	612	398	0.210
PEth (> 20 ng/mL)2	16 (31)	36 (69)	0.456
Length of stay (days)5	49	25	0.123
Standard drinks/week	25	52	0.136
	Nonresponse (n = 23)3	Response (n = 41)3
Age (years)	49	42	0.024
Albumin (g/dL)	2.1	2.6	0.003
Bilirubin (mg/dL)	24.5	16.9	0.010
Death	2 (9)	0	0.001
Transplanted	4 (17)	1 (2)
Rehab/intensive care units	4 (17)	0
Readmission/relapse4	7 (30)	18 (44)
Discharge)	6 (26)	22 (54)
Ethnicity			0.254
White	17 (27)	29 (45)
Black	1 (2)	6 (9)
Hispanic/Latino	5 (8)	4 (6)
Other	0 (0)	2 (3)

¹n = 52, phosphatidylethanol (Peth) performed prior to steroid initiation.

²Positive PEth value > 20 ng/mL.

³n = 64, alcohol-associated hepatitis treated with steroid.

⁴Low mortality risk (i.e., mild infection, headache, pain).

⁵Length of abstinence from alcohol consumption subjectively reported by patient.

Nonresponse: Post steroid day 4 or day 7 Lille score ≥ 0.45; Peth: Phosphatidylethanol; Response: Post steroid day 4 or day 7 Lille score < 0.45.