Expression and clinical significance of short-chain fatty acids in patients with intrahepatic cholestasis of pregnancy

Table 1 Maternal and fetal clinical characteristics of patients with intrahepatic cholestasis of pregnancy and normal pregnant group, mean ± SD

Index		NP (n = 30)	ICP (n = 34)	P value
Baseline information	Maternal fundal height (cm)	34.60 ± 2.43	32.79 ± 3.19	0.014
	Maternal abdominal circumference (cm)	102.17 ± 5.89	97.47 ± 8.73	0.016
Blood routine	Hemoglobin (g/L)	4.20 ± 0.60	3.79 ± 0.44	0.003
	Hematocrit	127.33 ± 12.14	117.41 ± 12.32	0.002
	Leukocyte (× 109/L)	10.70 ± 3.23	8.10 ± 2.34	< 0.001
	Percentage of neutrophils (%)	77.96 ± 6.69	72.50 ± 8.86	0.008
Liver function	Direct bilirubin (μmol/L)	1.45 ± 0.73	2.37 ± 2.09	0.018
	Glutamic-pyruvic transaminase (U/L)	9.40 ± 3.19	38.33 ± 48.76	< 0.001
	Total bile acid (μmol/L)	2.65 ± 1.35	22.64 ± 18.11	< 0.001
	Cholyglycine (mg/L)	1.38 ± 0.18	6.58 ± 8.92	< 0.001
Fetal ultrasound	Biparietal diameter (mm)	93.40 ± 3.56	91.49 ± 4.09	0.032
	Fetal head circumference (mm)	334.40 ± 11.03	327.86 ± 12.40	0.029
	Fetal abdominal circumference (mm)	337.20 ± 19.36	326.57 ± 18.67	0.028
	Fetal femur length (mm)	71.47 ± 3.47	68.89 ± 3.87	0.007
Pregnancy outcome	Gestational week of delivery (wk)	39.39 ± 0.84	37.82 ± 1.64	< 0.001
	Vaginal delivery [n (%)]	23(76.67)	11(32.35)	< 0.001
	Neonatal birth weight (g)	3476.00 ± 436.12	3063.14 ± 386.62	< 0.001

ICP: Intrahepatic cholestasis of pregnancy; NP: Normal pregnant.

Table 2 Pearson’s correlation between maternal serum short-chain fatty acids and cord blood short-chain fatty acids

	ALL		NP		ICP
	r (Pearson)	P value	r (Pearson)	P value	r (Pearson)	P value
Acetic acid	0.33	0.03	0.03	0.90	-0.24	0.45
Propionic acid	9.42E-04	1.00	0.02	0.93	-0.12	0.70
Isobutyric acid	-0.21	0.19	0.21	0.35	-0.17	0.61
Butyric acid	0.11	0.48	0.05	0.82	0.35	0.26
Isovaleric acid	0.05	0.76	-0.12	0.59	0.04	0.89
Valeric acid	-0.17	0.29	-0.23	0.30	-0.03	0.92
Caproic acid	0.38	0.01	0.22	0.33	0.18	0.58

ALL: Intrahepatic cholestasis of pregnancy and normal pregnant; ICP: Intrahepatic cholestasis of pregnancy; NP: Normal pregnant.