Editorial
Copyright ©The Author(s) 2024.
World J Hepatol. Oct 27, 2024; 16(10): 1151-1157
Published online Oct 27, 2024. doi: 10.4254/wjh.v16.i10.1151
Table 1 Impact of Antiviral therapy on outcomes of patients with advanced stages of chronic hepatitis B
Ref.
Study design
Drug/duration
HBV patients
number
Baseline cirrhosis
Main results
Fontana et al[18], 2002ProspectiveLamivudine for 16 months154154 (DC)78% had very high mortality due to complications of liver failure
Dienstag et al[38], 2003Prospective Lamivudine, 3 years63 11Cirrhosis regressed in 8 of 11 patients (73%)
Hadziyannis et al[37], 2006ProspectiveAdefovir, up to 240 weeks125 458% had reversal of bridging fibrosis/cirrhosis; 3 had cirrhosis reversal
Schiff et al[39] 2008Randomized Entecavir/lamivudine for 48 weeks1633 24571% of Entecavir and 61.5% of lamivudine group showed fibrosis regression
Das et al[40], 2010Retrospective-prospectiveLamivudine/adefovir151151 (DC)Better 5 year survival rate in treated patients for > 6 months
Andersen et al[41], 2011ProspectiveNucleoside(tide) analogues, 50.5 months66 5326 (49%) had regression of cirrhosis
Marcellin et al[9], 2013RandomizedTDF/adefovir for 48 weeks then open-label TDF641 9671 of 96 (74%) became non-cirrhotic at 5 years
Du et al[42], 2013ProspectiveLamivudine/adefovir for 44.5 months48 3323 (69%) patients had reversal of cirrhosis
Srivastava et al[43], 2013ProspectiveTDF 2 years9696 (DC)MELD score of > 20 a/w 58 fold increased mortality
Papatheodoridis et al[16], 2018Multicenter prospectiveTDF/entecavir for 6 years1951526Significant improvement in overall survival
Hsu et al[13] 2021RandomizedTDF for 3 years730016%- reduced fibrosis, 58% non- progression
Desalegn et al[44], 2019ProspectiveTDF for 2 years27635 (DC)24 fold increase in mortality if decompensated cirrhosis
Ismael et al[3], 2024 Prospective TDF19335 (DC)60% of all death occurred due to decompensated liver disease with in first 6 months