Positive autoantibodies in living liver donors

Table 1 Demographics and characteristics of living donor liver transplant recipients

		Recipients of transplants from autoantibody positive donors (n = 37), No. (%)	Recipients of transplants from autoantibody negative donors (n = 78), No. (%)	P value
Race/Ethnicity				0.61
	Caucasian	33 (89)	70 (90)
	Hispanic	3 (8)	3 (4)
	Black	0 (0)	4 (5)
	Asian	1 (3)	1 (1)
Gender				0.23
	Male	15 (41)	39 (50)
	Female	22 (59)	39 (50)
Cause for transplantation				0.11
	Alcoholic cirrhosis	6 (16)	8 (10)
	Non-alcoholic steatohepatitis	16 (43)	19 (24)
	Hepatitis B	0 (0)	1 (1)
	Hepatitis C	4 (11)	4 (5)
	PSC	8 (22)	13 (17)
	PBC	1 (3)	3 (4)
	AIH	1 (3)	5 (6)
	With PBC	0	1
	With PSC	1	2
	AIH only	0	2
	Malignancy	0 (0)	7 (9)
	Other1	1 (3)	17 (22)
Age at transplantation		55 ± 15	50 ± 14	0.13
Average BMI		28 ± 6	27 ± 6	0.22
Average MELD at transplantation		15 ± 5	14 ± 5	0.71

¹Other includes biliary atresia 2 (2%), congenital hepatic fibrosis 2 (2%), cryptogenic 6 (5%), common variable immunodeficiency 1 (1%), cystic fibrosis 1 (1%), polycystic liver disease 2 (2%), sarcoidosis 1 (1%), telomere syndrome 1 (1%), and portal vein thrombosis 1 (1%). AIH: Autoimmune hepatitis; BMI: Body mass index; MELD: Model for end-stage liver disease; PBC: Primary biliary cholangitis; PSC: Primary sclerosing cholangitis.

Table 2 Donor complications in the Autoantibody Positive and Negative Groups

	Autoantibody positive (n = 37), No. (%)	Autoantibody negative (n = 78), No. (%)
Chronic abdominal or incisional pain	2 (5)	1 (1)
Diaphragmatic or incisional hernia		6 (8)
Duodenal ulcer		1 (1)
Pneumothorax requiring chest tube		1 (1)
Portal vein stenosis	1 (3)	2 (3)
Wound hematoma requiring exploration		1 (1)
Wound infection	2 (8)	4 (5)
Total	5 (14)	16 (21)

Table 3 List of post-transplantation complications other than death, rejection, stricture, or infection

	Number of recipient complications in positive autoantibodies group, n = 37 (%)	Number of recipient complications in negative autoantibodies group, n = 78 (%)
Bowel perforation	0	1 (1)
Gastric perforation	1 (3)	0
Kidney rupture	0	1 (1)
Diaphragmatic hernia requiring urgent exploratory laparotomy	1 (3)	0
Intraabdominal hematoma	0	1 (1)
Retroperitoneal hematoma	1 (3)	0
Splenic artery bleeding	0	1 (1)
Splenic artery aneurysm s/p embolization	1 (3)	0
Hepatic and splenic vein thrombosis	1 (3)	0
Hepatic artery thrombosis	1 (3)	2 (3)
Hepatic artery stenosis	2 (5)	1 (1)
Hepatic artery-portal vein fistula s/p embolization	0	1 (1)
Portomesenteric thrombosis	0	1 (1)
Portal vein thrombosis	1 (3)	2 (3)
Portal vein stenosis	0	1 (1)
Portal vein thrombosis and stenosis, bleeding from exploratory laparotomy	0	1 (1)
Portal steal syndrome	1 (3)	1 (1)
Small for size syndrome	0	1 (1)
Post-transplant lymphoproliferative disorder	1 (3)	0
Total	11 (30)	15 (19)

Table 4 Comparison of recipient outcomes in those who received living liver transplants from autoantibody positive versus autoantibody negative donors

	Positive autoantibody (n = 37)	Negative autoantibody (n = 78)	Odds ratio (95%CI)	P value
Death	4 (11)	8 (10)	1.06 (0.22-4.31)	1
Strictures	20 (54)	28 (36)	2.09 (0.88-5.02)	0.07
Rejection	9 (24)	12 (15)	1.76 (0.58-5.16)	0.30
Infection	9 (24)	23 (29)	0.77 (0.28-2.02)	0.66
Other complications	11 (30)	15 (19)	1.77 (0.64-4.77)	0.24