Regulation of PPAR-γ activity in lipid-laden hepatocytes affects macrophage polarization and inflammation in nonalcoholic fatty liver disease

doi:10.4254/wjh.v14.i7.1365

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Jul 27, 2022 (publication date) through Nov 26, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jul 27, 2022; 14(7): 1365-1381
Published online Jul 27, 2022. doi: 10.4254/wjh.v14.i7.1365

Table 1 Murine primers

Primer	Forward (5′-3′)	Reverse (5′-3′)
Nos2	GTGTTCCACCAGGAGATGTTG	CTCCTGCCCACTGAGTTCGTC
Tnf	TCTTCTCATTCCTGCTTGTGG	GGTCTGGGCCATAGAACTGA
Il-6	GTTCTCTGGGAAATCGTGGA	GGAAATTGGGGTAGGAAGGA
Arg1	CTCCAAGCCAAAGTCCTTAGAG	AGGAGCTGTCATTAGGGACATC
Mrc2	TACAGCTCCACGCTATGGATT	CACTCTCCCAGTTGAGGTACT
Il-10	GTTACTTGGGTTGCCAAG	TTGATCATCATGTATGCTTC
Acox1	ACCAGCCCAACTGTGACTTC	ACAAAGGCATGTAACCCGTA
Cpt1a	CTTCCCATTTGACACCTTTG	ATACGTGAGGCAGAACTTGC
Srebp1c	ACAGCAACCAGAAGCTCAAG	TGCCCTCCATAGACACATCT
Fasn	TTGGGTGCTGACTACAACCT	TGGATGATGTTGATGATGGA
Keap1	AGAGCGGGATGAGTGGCA	GCTGAATTAAGGCGGTTTGTC
Nrf2	CTTTAGTCAGCGACAGAAGGAC	AGGCATCTTGTTTGGGAATGTG
Ho-1	AGACCGCCTTCCTGCTCAACAT	TCTGACGAAGTGACGCCATCTGT
Nlrp3	GAGTTCTTCGCTGCTATGT	ACCTTCACGTCTCGGTTC
Caspase-1	TGGAGAGAAACAAGGAG	TTGAAGAGCAGAAAGCAAT
Il-1β	TCTTTGAAGTTGACGGACCC	TGAGTGATACTGCCTGCCTG
Ppar-γ	GCCCTTTACCACAGTTGATTTCT	GTGATTTGTCCGTTGTCTTTCCT
β-actin	TGTTACCAACTGGGACGACA	CTGGGTCATCTTTTCACGGT

Acox1: Acyl-CoA oxidase 1; Arg1: Arginine-1; Caspase-1: Cysteinyl aspartate-specific proteinase-1; Cpt1a: Carnitine palmitoyltransferase 1A; Fasn: Fatty acid synthase; Ho-1: Heme oxygenase-1; Il: Interleukin; Nos: Nitric oxide synthase; Keap1: Kelch-like ECH-associated protein 1; Mrc2: Mannose receptor 2; Nlrp3: NLR family pyrin domain-containing 3; Nrf2: NF-E2-related factor 2; Ppar-γ: Peroxisome proliferators-activated receptor-γ; Srebp1c: Sterol-regulatory element-binding protein 1C; Tnf: Tumor necrosis factor.

Citation: Li XY, Ji PX, Ni XX, Chen YX, Sheng L, Lian M, Guo CJ, Hua J. Regulation of PPAR-γ activity in lipid-laden hepatocytes affects macrophage polarization and inflammation in nonalcoholic fatty liver disease. World J Hepatol 2022; 14(7): 1365-1381
URL: https://www.wjgnet.com/1948-5182/full/v14/i7/1365.htm
DOI: https://dx.doi.org/10.4254/wjh.v14.i7.1365