Predictors of mortality at 28-days in infection associated acute kidney injury in cirrhosis

Table 1 Baseline characteristics of patients in Infection and non-infection acute kidney injury groups

Variables	Infection AKI (n = 67)	Non-infection AKI (n = 52)	P value
Age (yr, mean ± SD)	42 ± 23	41 ± 21	0.23
Males, n (%)	58 (86%)	47 (90%)	0.31
Hb (gm/dL)	8.5 (3.6-14.7)	8.1 (3-14)	0.037
TLC (× 103/mm3)	17 (2-40)	7.8 (2.5-18)	0.001
Platelet count (× 109/L)	110 (60-200)	130 (80-220)	0.335
Bilirubin (mg/dL)	11.3 (0.8-46.6)	4.4 (0.8-27.9)	0.003
INR	2.1 (0.9-3.9)	1.9 (0.9-3.6)	0.045
Albumin (gm/dL)	2.3 (1.6-3.9)	2.5 (1-3.7)	0.04
Creatinine (mg/dL)	2.6 (1.4-6)	2.2 (1.2-5.4)	0.016
Sodium (mEq/L)	132.5 (116-164)	135.9 (120-151)	0.04
HE, n	47	22	0.03
CTP	12 (6-15)	11 (6-14)	0.73
MELD	27 (11-38)	24 (10-35)	0.95

Data expressed as median (range) otherwise expressed. Hb: Hemoglobin; INR: International normalized ratio; CTP: Child-Turcotte Pugh score; MELD: Model for end stage liver disease.

Table 2 Mortality data among infection and non-infection acute kidney injury groups

Mortality	Infection AKI (n = 67)	Non-infection AKI (n = 52)		P Value
		Diuretic-induced (n = 16)	Pre-renal (n = 36)
28-d (n = 42)	38	0	4	< 0.0001
90-d (n = 20)	11	3	6	0.206

Data expressed as frequency. AKI: Acute kidney injury.

Table 3 Univariate and multivariate analysis of survivors and non-survivors at 28-d

Variables	Survivors (n = 77)	Non-survivors (n = 42)	Univariate	Multivariate
Age (yr, mean ± SD)	41 ± 21	40 ± 22	0.73	-
Males, n (%)	69 (86.9%)	36 (85.7%)	0.41	-
Hb (gm/dL)	8.3 (4-14)	8.4 (3.4-14)	0.838	-
TLC (× 103/mm3)	11 (2.5-37)	17.4 (2-39)	0.001	-
Platelet count (× 109/L)	114.6 (100-200)	130 (60-220)	0.520	-
Bilirubin (mg/dL)	4.2 (0.5-30)	15.7 (0.2-46)	0.001	< 0.001
INR	1.8 (1-3.7)	2.1 (1.2-3.8)	0.006	-
Albumin (gm/dL)	2.4 (1-3.7)	2.4 (1.8-3.9)	0.689	-
Sodium (mEq/L)	135 (116-164)	131 (120-146)	0.336	-
HE, n	32	37	< 0.001	< 0.01

Data expressed as median (range) otherwise expressed. INR: International normalized ratio; Hb: Hemoglobin; TLC: Total leukocyte count; HE: Hepatic encephalopathy.

Table 4 Univariate and multivariate analysis of survivors and non-survivors in infection acute kidney injury group (n = 67) at 28-d

Variables	Survivors (n = 29)	Non-survivors (n = 38)	Univariate	Multivariate
Age (yr, mean ± SD)	40 ± 21	40 ± 22	0.81	-
Males, n (%)	23 (79%)	35 (92%)	0.9	-
Hb (gm/dL)	8.1 (4-14)	7.5 (3.4-14)	0.06	-
TLC (× 103/mm3)	10 (2.5-36)	18.3 (2-39)	0.001	-
Platelet count (× 109/L)	112 (65-203)	125 (60-220)	0.520	-
Bilirubin (mg/dL)	4.6 (1.2-30)	16.3 (1.5-46)	0.004	0.01
INR	1.9 (1.3-3.7)	2.1 (1.1-3.8)	0.005	-
Albumin (gm/dL)	2.3 (1-3.6)	2.4 (1.5-3.9)	0.73	-
Sodium (mEq/L)	135 (116-154)	132 (119-148)	0.45	-
HE, n	10	37	< 0.001	< 0.01

Data expressed as median (range) otherwise expressed. INR: International normalized ratio; Hb: Hemoglobin; TLC: Total leukocyte count; HE: Hepatic encephalopathy.