Takotsubo cardiomyopathy in orthotopic liver transplant recipients: A cohort study using multi-center pooled electronic health record data

Table 1 Baseline characteristics of patients with liver transplant versus those without liver transplant (control group)

	Liver transplant		No liver transplant
	n = 38740	%	n = 37679800	%
Takotsubo cardiomyopathy	110	0.3	13430	0.0
Age > 65	14780	38.2	8349380	22.2
Age 18-65	23470	60.6	22449470	59.6
Age < 18	500	1.3	6659540	17.7
Male	16230	41.9	16676780	44.3
Female	22510	58.1	20665100	54.8
Caucasian	30150	77.8	22446830	59.6
African American	6060	15.6	4315410	11.5
Obesity	840	2.2	5018440	13.3
Cardiomyopathy	1770	4.6	762420	2.0
Hypertension	390	1.0	3465120	9.2
Diabetes Mellitus	710	1.8	5484800	14.6
Hyperlipidemia	1220	3.1	10758820	28.6
Atherosclerosis	770	2.0	3848890	10.2
Coronary artery disease	730	1.9	3395870	9.0
Myocardial infarction	430	1.1	1528310	4.1
Ischemic heart disease	620	1.6	2285770	6.1
Chronic kidney disease	530	1.4	2052700	5.4
Alcohol abuse	80	0.2	1013590	2.7
Smoking	290	0.7	6369120	16.9
Sepsis	690	1.8	2101780	5.6
Atrial fibrillation	1030	2.7	2659760	7.1
Supraventricular arrhythmia	200	0.5	75580	0.2
Ventricular arrhythmia	590	1.5	415060	1.1

Table 2 Baseline characteristics of patients with Takotsubo cardiomyopathy following liver transplant versus those without a history of Takotsubo cardiomyopathy following liver transplant (control group)

	Takotsubo cardiomyopathy		No takotsubo cardiomyopathy		P value
	n = 110	%	n = 38640	%
Age > 65	60	54.5	14720	38.1	0.0005
Age 18-65	50	45.5	23400	60.6	0.0014
Age < 18	0	0.0	500	1.3
Male	30	27.3	16200	41.9	0.0022
Female	80	72.7	22440	58.1	0.0022
Caucasian	100	90.9	30060	77.8	0.0016
African American	5	4.5	6060	15.7	0.0042
Obesity	30	27.3	10500	27.2	0.9814
Hypertension	40	36.4	9250	23.9	0.0027
Diabetes mellitus	60	54.5	17910	46.4	0.0867
Hyperlipidemia	70	63.6	19720	51.0	0.009
Atherosclerosis	30	27.3	5320	13.8	0.0001
Coronary artery disease	50	45.5	12280	31.8	0.0001
Chronic kidney disease	60	54.5	13350	34.5	< 0.0001
Alcohol abuse	10	9.1	3060	7.9	0.6499
Smoking	40	36.4	10930	28.3	0.0621
Sepsis	60	54.5	6530	16.9	< 0.0001
Atrial fibrillation	50	45.5	5470	14.2	< 0.0001
Supraventricular arrhythmia	60	54.5	6740	17.4	< 0.0001
Ventricular arrhythmia	5	4.5	210	0.5	< 0.0001
Anxiety disorder	60	54.5	11700	30.3	< 0.0001
Mood disorder	60	54.5	14470	37.4	0.0003
Seizure disorder	10	9.1	1750	4.5	0.025