Hepatitis C: Problems to extinction and residual hepatic and extrahepatic lesions after sustained virological response

Table 1 Factors that influence the surveillance of hepatocarcinoma

Factors existing previous to sustained virological response	Factors existing after sustained virological response
Comorbidities (steatosis, diabetes mellitus, excessive alcohol consumption)	Persistently elevated ALT, AST, GGT, alpha-fetoprotein, liver stiffness, FIB-4, APRI, or VITRO
Male gender	Hypoalbuminemia
Age > 64 years	Increasing body weight (?)
F4
Portal hypertension
Elevated FIB-4, APRI, alpha-fetoprotein
History of decompensation
History of IFN therapy (?)
HCV genotypes 1 and 3 (?)

Reference[115], modified. FIB-4: Fibrosis 4 index (includes serum levels of AST and ALT, platelet count and age); APRI: Aspartate aminotransferase to platelet ratio; IFN: Interferon; HCV: Hepatitis C virus; ALT: Alanine amino-tranferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamil transferase; VITRO: Von Willebrand Factor Antigen to Platelets ratio.