Leukocyte cell-derived chemotaxin-2 and fibroblast growth factor 21 in alcohol-induced liver cirrhosis

Table 1 Patients’ demographics and clinical characteristics

	Control group (n = 17)	Liver cirrhosis		P value
		Pugh-Child A + B (n = 37)	Pugh-Child C (n = 32)
Age (yr)	43.7 ± 14.6	55.7 ± 12.1	55.9 ± 10.2	0.021
Percentage of males (%)	64.3%	73%	72.7%	0.52
Body weight (kg)	67.6 ± 8.9	73 ± 11.4	75.5 ± 12.8	0.17
Height (cm)	173 ± 5.9	174 ± 8	173 ± 7.6	0.64
Duration of alcohol abuse (yr)	-	15.7 ± 8.2	18.7 ± 8.3	0.98
Oesophageal varices (%)	-	32.4%	81.8%	< 0.0001
Encephalopathy (%)	-	32.4%	83.9%	< 0.0001
Ascites (%)	-	40.5%	90.9%	< 0.0001
Total bilirubin (mg/dL)	0.6 ± 0.3	4.6 ± 6.9	10.5 ± 9.2	< 0.0001
INR	-	1.36 ± 0.35	1.95 ± 0.56	< 0.0001
Albumin (g/dL)	-	3.1±0.8	2.4±0.4	0.0002
Total protein (g/dL)	6.3 ± 0.3	6.4 ± 1	5.9 ± 0.9	0.16
Alanine aminotransferase (U/L)	17.9 ± 6	65.3 ± 139.9	50.6 ± 87.3	0.018
Aspartate aminotransferase (U/l)	18.3 ± 7	128.1 ± 173.5	120 ± 164.7	< 0.0001
Platelets (G/L)	231.4 ± 29.8	173 ± 105.4	127.8 ± 72.3	0.0004
Mean corpuscular volume (fL)	84.8 ± 3.5	91.2 ± 9.1	95.5 ± 9	0.0002
Urea (mg/dL)	-	27.5 ± 16.1	58.2 ± 43.7	0.065
Sodium (mmol/l)	140 ± 3.3	133.8 ± 5	131.9 ± 6.7	< 0.0001
Potassium (mmol/L)	4.4 ± 0.4	3.8 ± 0.7	3.9 ± 0.8	0.019
C-reactive protein (mg/L)	2.5 ± 2.3	19.8 ± 21	32.7 ± 27.8	< 0.0001
Angiotensinogen (ng/mL)	1006.91 ± 610.49	1117.04 ± 873.69	1468.7 ± 817.33	0.22

INR: International normalized ratio.

Table 2 Levels of selected biochemical parameters according to the stage of liver cirrhosis

	Control group	Liver cirrhosis		P value
		Pugh-Child A + B	Pugh-Child C
LECT2 (ng/mL)	18.99 ± 5.36	11.06 ± 6.47	8.06 ± 5.74	< 0.0001
FGF-1 (pg/mL)	37.94 ± 40.4	144.77 ± 14.42	164.52 ± 169.46	0.01
FGF-21 (pg/mL)	13.52 ± 7.51	44.27 ± 64.19	45.4 ± 51.69	0.008

LECT2: Leukocyte cell-derived chemotaxin-2; FGF-1: Fibroblast growth factor 1; FGF-21: Fibroblast growth factor 21.

Table 3 Correlations between leukocyte cell-derived chemotaxin-2 and other clinical and laboratory parameters (only those statistically significant were included)

Pair of variables		Correlation coefficient
		R	P value
LECT2	Age	-0.29	0.048
	Total bilirubin	-0.59	< 0.0001
	Platelets	0.34	0.02
	Alanine transaminase	-0.43	0.003
	C-reactive protein	-0.4	0.008
	Angiotensinogen	-0.51	< 0.0001
	FGF-1	-0.38	0.004
	FGF-21	-0.39	0.004

LECT2: Leukocyte cell-derived chemotaxin-2; FGF-1: Fibroblast growth factor 1; FGF-21: Fibroblast growth factor 21.

Table 4 Independent factors associated with leukocyte cell-derived chemotaxin-2 concentration (multiple regression)

Effect	B*	SE with B*	B	SE with B	P value
Constant			30.64	3.68	< 0.0001
Angiotensinogen	-0.423	0.114	-0.004	0.001	0.001
Alanine aminotransferase	-0.341	0.115	-0.02	0.005	0.005
Total bilirubin	-0.279	0.108	-0.25	0.099	0.014
Age	-0.275	0.109	-0.16	0.064	0.016

B*: Standardized coefficient (Beta). Model: R = 0.79; R² = 0.64, adjusted R² = 0.59; P < 0.0001.