Dengue hemorrhagic fever and the liver

Table 1 Clinical and laboratory findings of Dengue hemorrhagic fever with liver involvement

Investigators	No. of patients	Hepatomegaly (%)	Elevated AST (%)	Elevated ALT (%)	Hyper-bilirubinemia (%)	Low albumin (%)
Bandyopadhyay et al[16]	110	79.1	92.7	78.2	4.5	66.4
Kittitrakul et al[17]	127	34.6	88.2	69.3	N/A	N/A
Saha et al[18]	570	28.6	N/A	N/A	N/A	N/A
Roy et al[19]	120	80.8	94.2	89.2	N/A	N/A
Nascimento et al[20]	68	N/A	83.8	73.5	N/A	35.3
Karoli et al[21]	138	N/A	N/A	92.0	48.0	N/A
Lee et al[22]	690	N/A	86.0	46.0	N/A	N/A
Jagadishkumar et al[23]	110	79.0	93.6	78.2	N/A	N/A
Parkash et al[24]	699	N/A	95.0	86.0	N/A	N/A
Trung et al[25]	644	34.8	97.0	97.0	N/A	N/A
Wong and Shen [26]	127	11.8	90.6	71.7	13.4	N/A
Uehara et al[27]	41	10.0	80.5	61.0	N/A	48.4
Itha et al[28]	45	N/A	96.0	96.0	30.0	76.0
Fernando et al[29]	55	36.4	90.1	81.8	3.6	72.7
Souza et al[30]	1585	N/A	63.4	45.0	N/A	N/A
Kuo et al[31]	270	N/A	93.3	82.2	7.2	N/A

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; N/A: Not applicable.

Table 2 The incidence and mortality rate of acute liver failure in Dengue hemorrhagic fever patients with liver involvement

Investigators	Countries	Study population	Incidence rate (%)	Mortality rate (%)
Teerasarntipan et al[46]	Thailand	2311 adults	0.71	58.82
Devarbhavi et al[34]	Qatar	10108 adults	0.35	58.30
Laoprasopwattana et al[45]	Thailand	3630 children	1.10	68.30
Trung et al[25]	Vietnam	644 adults	0.77	20.00
Kye Mon et al[44]	Thailand	1926 age ≥ 15 yr	0.31	66.70