Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis

doi:10.4254/wjh.v13.i11.1512

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 27, 2021; 13(11): 1512-1533
Published online Nov 27, 2021. doi: 10.4254/wjh.v13.i11.1512

Table 1 miRNA and compounds targeting acyl-CoA synthetases

Type	Name	Target	Mechanism	Ref.
miRNA	miR-205	ACSL4/ACSL1	Inhibition of ACSL4/ACSL1 in hepatocellular carcinoma	[155,171]
	miR-211-5p	ACSL4	Inhibition of ACSL4 in hepatocellular carcinoma	[172]
	miR-19b-1	ACSL1/ACSL4/SCD1	Inhibition of ACSL1/ACSL4/SCD1 axis in colorectal cancer	[173]
	miR-142-3p	ACSL1/ACSL4/SCD1	Inhibition of ACSL1/ACSL4/SCD1 axis in colorectal cancer	[173,174]
	miR-34c	ACSL1	Inhibition of ACSL1 and induction of liver fibrogenesis	[175]
	miR-497-5p	ACSL5	Inhibition of ACSL5 in colon cancer	[170]
Compounds	Triacsin C	ACSL1/ACSL3/ACSL4 and ACSL5¹	Inhibition of ACSL1/ACSL3/ACSL4 and ACSL5¹	[177,178]
	Roglitazone Pioglitazone Troglitazone	ACSL4	Inhibition of ACSL4	[179-181]
	Lipofermata	FATP2	Inhibition of FATP2	[191,192]
	Grassofermata	FATP2	Inhibition of FATP2	[191,193,194]
	Ursodiol chenodiol	FATP5	Inhibition of FATP5 in liver	[195]
	Fenofibrate	PPARα	Indirect activation of FATP in liver predominantly	[196,197]

¹Triacsin C is also competitive inhibitor of ACSL5 when used in higher concentration.

Citation: Ma Y, Nenkov M, Chen Y, Press AT, Kaemmerer E, Gassler N. Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis. World J Hepatol 2021; 13(11): 1512-1533
URL: https://www.wjgnet.com/1948-5182/full/v13/i11/1512.htm
DOI: https://dx.doi.org/10.4254/wjh.v13.i11.1512