Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice

Table 1 Gut microbiota associated changes in non-alcoholic fatty liver disease and Non-alcoholic steatohepatitis subjects

Study	Subjects	Family	Genus
Zhu et al[14], 2012	3HC, BMI = 20 kg/m2	↑ Prevotellaceae	↑ Prevotella
		↑ Enterobacteriaceae1	↑ Escherichia1
	3Obese, BMI > 30 kg/m2	↓ Rikenellaceae	↓ Alistipes
		↓ Actinobacteria	↓ Bifidobacterium
	3NASH, BMI > 30 kg/m2	↓ Lachnospiraceae	↓ Blautia
		↓ Ruminococcaceae	↓ Faecalibacterium
Mouzaki et al[64], 2013	HC, BMI = 26 kg/m2	↑ Enterobacteriaceae	↑ Clostridium coccoides2
		↓ Lachnospiraceae2
	SS, BMI = 29 kg/m2
	NASH, BMI > 30 kg/m2
Raman et al[17], 2013	HC, BMI < 25 kg/m2	↑ Kiloniellaceae	↑ Lactobacillus
		↑ Pasteurellaceae	↑ Robinsoniella
	NAFLD, BMI > 30 kg/m2	↑ Lactobacillaceae	↑ Roseburia
		↑ Lachnospiraceae	↑ Dorea
		↑ Veillonellaceae	↓ Oscillibacter
		↓ Ruminococcaceae
		↓ Porphyromonadaceae
		Clostridiales	↓ Anaerosporobacter
Wong et al[18], 2013	HC, BMI = 22 kg/m2	↑ Succinivibronaceae	↑ Parabacteriodes
		↑ Porphyromonadaceae	↑ Allisonella
	NASH, BMI > 30 kg/m2	↓ Unclassified	↓ Faecalibacterium
Jiang et al[62], 2015	HC, BMI = 23 kg/m2	↑ Peptostreptococcaceae	↑ Anaerobacter
		↓ Ruminococcaceae	↑ Streptococcus
	NAFLD, BMI = 26 kg/m2		↑ Lactobacillus
			↑Escherichia
			↑ Clostridium XI
			↓ Oscillibacter
			↓ Odoribater
			↓ Alistipes
			↓ Flavonifractor
Boursier et al[19], 2016	HC, BMI > 30 kg/m2	↑ Bacteroidaceae	↑ Bacteroides
		↓ Prevotellaceae	↑ Ruminoccocus
	NASH, BMI > 30 kg/m2
		↓Erysipelotrichaceae	↓ Prevotella
Mouzaki et al[67], 2016	HC, BMI = 27 kg/m2		↓ Clostridium leptum
	NASH, BMI > 30 kg/m2
Del Chierico et al[65], 2017	3HC, BMI = 18 kg/m2	↓ Rikenellaceae4	↑ Bradyrhizobium4
			↑ Anaerococcus4
	3Obese, BMI = 26 kg/m2		↑ Peptoniphilus4
			↑ Propionibacterium acnes4
	3NAFLD, BMI = 26 kg/m2
			↑ Dorea4
	3NASH, BMI = 27 kg/m2
			↑ Ruminococcus4
			↓ Oscillospira4
Nobili et al[68],	3HC, BMI = 18 kg/m2		↑ Lactobacillus mucosae *12
2018	3Obese, BMI = 26 kg/m2
	3NAFLD, BMI = 26 kg/m2
	3NASH, BMI = 27 kg/m2
Da Silva et al[63], 2018	HC, BMI = 27 kg/m2	↓Bacteroidaceae	↓ Alistipes
		↓ Lachnospiraceae	↓ Anaerostipes
	NAFLD, BMI > 30 kg/m2	↓ Lactobacillaceae	↓ Bacteroides
		↓ Porphyromonadaceae	↓Blautia
		↓ Rikenellaceae	↓ Coprococcus
			↓ Dorea
			↓ Faecalibacterium
			↓ Lactobacillus
			↓Parabacteroides
			↓ Roseburia
			↓ Ruminococcus

¹Different from Obese;

²Different from Steatosis or non-alcoholic fatty liver disease;

³Children and adolescent;

⁴Differences between grouping patients and healthy control. BMI: Body mass index; HC: Healthy control; NAFLD: Non-alcoholic fatty liver disease; NASH: Non-alcoholic steatohepatitis; SS: Steatosis.