Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis

doi:10.4254/wjh.v11.i4.391

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World Journal of Hepatology

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World J Hepatol. Apr 27, 2019; 11(4): 391-401
Published online Apr 27, 2019. doi: 10.4254/wjh.v11.i4.391

Table 1 Characteristics of 83 patients with hidradenitis suppurative, Nonalcoholic fatty liver and Nonalcoholic steatohepatitis and intercalsses charactersitics

	HS only	NAFLD	P value	NASH	P value	NAFL	P value
n	51	32		12		20
Age, mean(SD)	43.04 (8.9)	41.32 (9.0)	0.564	41.58 (7.4)	0.602	40.55 (10.3)	0.315
Age cat (%)			0.646		0.463		0.629
< 30	3 (5.9)	4 (12.5)		1 (8.3)		3 (15.0)
30-39	16 (31.4)	8 (25.0)		2 (16.7)		6 (30)
40-49	18 (35.3)	14 (43.8)		7 (58.3)		7 (35.0)
> 50	14 (27.5)	6 (18.8)		2 (16.7)		4 (20.0)
Male, n (%)	17 (33.3)	14 (43.8)	0.623	5 (41.7)	0.835	9 (45.0)	0.52
Diabetes, n (%)	12 (23.5)	9 (28.1)	0.853	3 (25.0)	0.764	6 (30.0)	0.794
BMI, mean(SD)	28.31 (2.5)	27.56 (1.9)	0.381	27.58 (2.7)	0.376	27.55 (1.7)	0.218
bmi_cat (%)			0.559		0.515		0.384
Normal Weight	4 (7.8)	4 (12.5)		2 (16.7)		2 (10.0)
Overweight	38 (74.5)	26 (81.3)		9 (75.0)		17 (85.0)
Obese	9 (17.6)	2 (6.3)		1 (8.3)		1 (5.0)
IHS4, mean(SD)	9.57 (3.6)	11.32 (2.8)	0.025	12.67 (3.6)	0.009	9.40 (3.9).	0.861
IHS4 cat (%)			0.028		0.007		0.97
Mild	5 (9.8)	3 (9.4)		1 (8.3)		2 (10.0)
Moderate	24 (47.1)	10 (31.3)		0 (0)		10 (50.0)
Severe	22 (43.1)	19 (59.4)		11 (91.7)		8 (40)
Hurley (%)			0.494		0.197		0.785
1	5 (9.8)	3 (9.4)		1 (8.3)		2 (10.0)
2	24 (47.1)	6 (18.8)		1 (8.3)		5 (25.0)
3	22 (43.1)	23 (71.9)		10 (83.3)		13 (65.0)
Elevated_liver_enzymes, n (%)	19 (37.3)	9 (28.1)	0.617	4 (33.3)	0.998	5 (25.0)	0.482
ADDI_score, mean(SD)	2.55 (1.4)	3.72 (1.8)	< 0.001	5.33 (2.2)	< 0.001	2.75 (1.6)	0.603
Inflammatory comorbidities, n (%)	2 (3.9)	12 (37.5)	< 0.001	7 (58.3)	< 0.001	5 (25.0)	0.025
In detail (%)			0.001		< 0.001		0.047
Acne conglobata	1 (2.0)	0 (0)		0 (0)		0 (0)
Crohn disease	0 (0)	2 (6.3)		1 (8.3)		1 (5.0)
Lichen sclerosus	1 (2.0)	0 (0)		0 (0)		0 (0)
PASH	0 (0)	5 (15.6)		4 (33.3)		1 (5.0)
Psoriasis	0 (0)	2 (6.3)		1 (8.3)		1 (5.0)
Spondyloarthritis	0 (0)	2 (6.3)		1 (8.3)		1 (5.0)
Uveitis	0 (0)	1 (3.1)		0 (0)		1 (5.0)
Positive ultrasound, n (%)	11 (21.6)	32 (100.0)	< 0.001	12 (100.0)	< 0.001	20 (100.0)	< 0.001
NASH	0 (0)	12 (37.5)	< 0.001	12 (100.0)		0 (0)
NAFL	0 (0)	20 (62.5)	< 0.001	0 (0)		20 (100.0)

ADDI: Autoinflammatory disease damage index; BMI: Body mass index; HS: Hidradenitis suppurativa; IHS4: International Hidradenitis Suppurativa Severity Scoring System, NASH: NonAlcoholic SteatoHepatitis, NAFL: NonAlcoholic Fatty Liver, PASH: Pyoderma gangrenosum, Acne, and hidradenitis suppurativa; SD: Standard deviation. Normal weight: 18.5–24.9 kg/m², Overweight: 25–29.9 kg/m² Obese: >29. 9 kg/m².

Table 2 Differences among hidradenitis suppurativa patients with and without diabetes

	Non diabetes	Diabetes	P value
n	62	21
Age, mean(SD)	42.44 (9.4)	41.62 (8.2)	0.722
Age cat (%)			0.203
< 30	4 ( 6.5)	3 (14.3)
> 50	17 (27.4)	3 (14.3)
30-39	20 (32.3)	4 (19.0)
40-49	21 (33.9)	11 (52.4)
Male, n (%)	21 (33.9)	10 ( 47.6)	0.387
Diabetes, n (%)	0 ( 0.0)	21 (100.0)	<0.001
BMI, mean(SD)	28.10 (2.6)	27.81 (1.4)	0.636
bmi_cat (%)			0.161
Normal Weight	8 (12.9)	0 ( 0.0)
Obese	9 (14.5)	2 ( 9.5)
Overweight	45 (72.6)	19 ( 90.5)
IHS4, mean(SD)	10.37 (3.6)	8.81 (4.1)	0.101
IHS4 cat, n (%)			0.051
Mild	4 ( 6.5)	4 ( 19.0)
Moderate	23 (37.1)	11 ( 52.4)
Severe	35 (56.5)	6 ( 28.6)
Hurley, n (%)			0.022
1	4 ( 6.5)	4 ( 19.0)
2	14 (22.6)	9 ( 42.9)
3	44 (71.0)	8 ( 38.1)
Elevated_liver_enzymes, n (%)	21 (33.9)	7 ( 33.3)	1
ADDI_score, mean(SD)	3.13 (1.8)	2.62 (2.0)	0.275
Inflammatory comorbidities, n (%)	9 (14.5)	5 ( 23.8)	0.518
In.detail, n (%)			0.563
	53 (85.5)	16 ( 76.2)
Acne conglobata	1 ( 1.6)	0 ( 0.0)
Crohn	1 ( 1.6)	1 ( 4.8)
Lichen sclerosus	0 ( 0.0)	1 ( 4.8)
PASH	4 ( 6.5)	1 ( 4.8)
Psoriasis	1 ( 1.6)	1 ( 4.8)
Spondyloarthritis	1 ( 1.6)	1 ( 4.8)
Uveitis	1 ( 1.6)	0 ( 0.0)
Positive_ultrasound, n (%)	31 (50.0)	12 ( 57.1)	0.754
NASH, n (%)	9 (14.5)	3 ( 14.3)	1
NAFL, n (%)	14 (22.6)	6 ( 28.6)	0.795
Disease, n (%)			0.853
HS only	39 (62.9)	12 ( 57.1)
NAFL	14 (22.6)	6 ( 28.6)
NASH	9 (14.5)	3 ( 14.3)

ADDI: Autoinflammatory Disease Damage Index; BMI: Body mass index; HS: Hidradenitis suppurativa; IHS4: International Hidradenitis Suppurativa Severity Scoring System; NASH: Non-alcoholic steatohepatitis; NAFL: Nonalcoholic fatty liver; PASH: Pyoderma gangrenosum, Acne, and hidradenitis suppurativa; SD: Standard deviation. Normal weight: 18.5–24.9 kg/m²; Overweight: 25-29.9 kg/m²; Obese: > 29.9 kg/m².

Citation: Damiani G, Leone S, Fajgenbaum K, Bragazzi NL, Pacifico A, Conic RR, Pigatto PD, Maiorana C, Poli P, Berti E, Pace MC, Malagoli P, Bettoli V, Fiore M. Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis. World J Hepatol 2019; 11(4): 391-401
URL: https://www.wjgnet.com/1948-5182/full/v11/i4/391.htm
DOI: https://dx.doi.org/10.4254/wjh.v11.i4.391