Endoscopic ultrasound guided liver biopsy for parenchymal liver disease

Table 1 Current evidence of diagnostic accuracy and adverse event rates of endoscopic ultrasound guided liver biopsy

	Sample size	Diagnostic yield	Serious adverse events
Gleeson et al[28], 2009	9	0%	0%
Schulman et al[30], 2017	288	84%	NA (cadaveric tissue)
Stavropoulos et al[24], 2012	22	91%	0%
Diehl et al[29], 2015	110	98%	0.9%
Mok et al[32], 2018	40	98% (wet suction)	0%
Nieto et al[33], 2018	165	> 90%	1.8%
Adler et al[38], 2018	200	98.5%	0%

Table 2 Comparison of percutaneous liver biopsy with endoscopic ultrasound guided liver biopsy

	PC-LB	EUS-LB
Anatomical definition	Likely improved with ultrasound guidance	Better than PC-LB and the addition of Doppler reduces complications
Imaging resolution	Lower	Higher
Diagnostic yield/accuracy	Comparable
Sampling error	Higher	Lower
Access to liver lobes	Predominantly right lobe sampling	Can easily sample both right and left lobes
Average recovery time	10 h	4 h
Technical difficulty	Lower	High
Cost	Low	High

PC-LB: Percutaneous liver biopsy; EUS-LB: Endoscopic ultrasound guided liver biopsy.