Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation

Table 1 Clinical and demographic data at time of liver transplant listing and short-term clinical outcome of patients with and without central line-associated bloodstream infection

	No CLABSI	CLABSI	P value
n (%)	44 (70)	19 (30)
Male, n (%)	11 (25)	5 (26)	0.91
Race, n (%)
White	38 (86)	15 (79)	0.71
Black	5 (11)	3 (16)
Asian	1 (2)	1 (5)
Ethnicity, n (%)
Hispanic	25 (57%)	9 (47%)	0.49
Primary language non-English, n (%)	12 (27)	3 (16)	0.32
Insurance, n (%)			0.036
Public/none	25 (57)	16 (84)
Private	19 (43)	3 (16)
Kasai portoenterostomy timing, n (%)			0.99
≤ 100 d	28 (64)	12 (63)
> 100 d	2 (5)	1 (5)
Not performed	14 (32)	6 (32)
Age at listing, years, mean (SD)	0.59 (0.27)	0.61 (0.31)	0.89
Any home parenteral nutrition, n (%)	16 (36)	9 (47)	0.41
Anthropometrics
Length, cm, mean (SD)	64.5 (3.8)	64.3 (3.6)	0.82
Weight, kg, mean (SD)	6.9 (1.3)	6.6 (1.1)	0.38
Length z-score, mean (SD)	-1.26 (1.47)	-1.57 (1.24)	0.43
Weight z-score, mean (SD)	-0.96 (1.26)	-1.44 (0.98)	0.15
WFL z-score, mean (SD)	-0.21 (1.13)	-0.58 (0.91)	0.21
Laboratory
ALT, U/L, median (25th, 75th)	133 (90, 204)	128 (90, 233)	0.98
GGT, U/L, median (25th, 75th)	257 (106, 504)	364 (205, 800)	0.14
Albumin, g/dL, mean (SD)	3.1 (0.46)	3 (0.68)	0.88
Conjugated bilirubin, mg/dL, median (25th, 75th)	4.2 (0.95, 8.2)	3.7 (2, 5.7)	0.73
Total bilirubin, mg/dL, median (25th, 75th)	10.7 (3.5, 16.2)	11.3 (6.2, 12.7)	0.90
White blood cells, × 103/µL, median (25th, 75th)	10.2 (8.3, 15.6)	10.6 (7.4, 14.4)	0.88
Hemoglobin, g/dL, mean (SD)	9.9 (1.6)	10.2 (1.3)	0.56
Platelets, × 103/µL, median (25th, 75th)	123 (95, 217)	160 (102, 230)	0.41
INR, mean (SD)	1.6 (0.6)	2.3 (4.1)	0.28
BUN, mg/dL, mean (SD)	9.5 (5)	9.9 (4.6)	0.73
Prealbumin, mg/dL, mean (SD)	9.5 (3.6)	9.5 (4.3)	0.95
Clinical outcome			0.29
Transplanted	35 (80)	18 (95)
Died on the waitlist or removed for too ill	6 (14)	1 (5)
Removed from waitlist for too well	3 (7)	0

CLABSI: Central line-associated bloodstream infection; SD: Standard deviation; WFL: Weight-for-length; ALT: Alanine aminotransferase; GGT: Gamma glutamyl transferase; INR: International normalized ratio; BUN: Blood urea nitrogen.

Table 2 Demographic, clinical, and laboratory factors assessed as potential risk factors for central line-associated bloodstream infection

	HR	95%CI	P value
Male	0.934	0.335-2.6	0.89
Race
White	Reference
Black	1.156	0.334-4	0.819
Asian	1.089	0.143-8.298	0.934
Ethnicity
Hispanic	0.642	0.259	0.339
Primary Language non-English	0.531	0.154-1.832	0.317
Insurance
Private	Reference
Public/None	2.435	0.705-8.406	0.159
Kasai portoenterostomy timing
≤ 100 d	0.852	0.319-2.275	0.749
> 100 d	1.33	0.159-11.126	0.792
Not performed	Reference
Age at listing	1.883	0.379-9.36	0.439
Any home parenteral nutrition	0.811	0.323-2.035	0.656
Anthropometrics
Length at listing	1.069	0.937-1.219	0.323
Weight at listing	1.036	0.67-1.672	0.872
Length z-score at listing	0.942	0.674-1.317	0.728
Weight z-score at listing	0.836	0.55-1.271	0.403
WFL z-score at listing	0.858	0.579-1.271	0.445
Laboratory
ALT at listing	0.999	0.998-1.002	0.861
GGT at listing	1	0.999-1.001	0.176
Albumin at listing	0.853	0.314-2.314	0.775
Conjugated bilirubin at listing	0.991	0.91-1.079	0.842
Total bilirubin at listing	0.997	0.946-1.051	0.927
White blood cells at listing	1.016	0.93-1.109	0.724
Hemoglobin at listing	1.106	0.816-1.5	0.516
Platelets at listing	1.001	0.998-1.005	0.458
INR at listing	1.084	0.9593-1.225	0.196
BUN at listing	1.007	0.918-1.104	0.889
Prealbumin at listing	0.966	0.842-1.109	0.628

HR: Hazard ratio; CI: Confidence interval; WFL: Weight-for-length; ALT: Alanine aminotransferase; GGT: Gamma glutamyl transferase; INR: International normalized ratio; BUN: Blood urea mitrogen.