One in five hepatocellular carcinoma patients in the United States are Hispanic while less than 40% were eligible for liver transplantation

Table 1 Characteristics of the study cohort

	Hispanics		Asians		Non-Hispanic White
	Percent (%)	Frequency (n)	Percent (%)	Frequency (n)	Percent (%)	Frequency (n)
Sex
Female	26.7	3584	29.5	3273	24.9	9273
Male	73.3	9856	70.6	7840	75.1	27940
Age
< 50 yr	10.7	1440	10.7	1191	6.1	2268
50-64 yr	47.1	6325	36.4	4045	45.6	16973
> 65 yr	42.2	5675	52.9	5877	48.3	17972
Insurance
Medicare or Commercial	60.9	5969	66.3	5177	80.2	21265
Medicaid	33.5	3280	29.5	2299	16.1	4257
Uninsured	5.6	549	4.3	335	3.7	983
Year of diagnosis
2004-2006	17.6	2722	17.6	2713	51.8	8009
2007-2008	17.4	2115	16.3	1985	52.5	6376
2009-2010	18.9	2550	15.4	2084	51.3	6927
2011-2012	20.1	2870	13.9	2133	51.9	7690
2013-2014	20.1	3183	13.9	2198	51.7	8211
HCC SEER summary stage
Localized	54	6091	51.8	2250	52.6	8644
Regional	29.5	3324	31	1345	31.2	5129
Distant	16.5	1858	15	747	16.2	2652
HCC within Milan criteria
No	62	8337	59.1	2832	55.4	10530
Yes	38	5103	40.9	1958	44.6	8465

HCC: Hepatocellular carcinoma; SEER: Surveillance, Epidemiology, and End Results.

Table 2 Proportion of Hispanic hepatocellular carcinoma patients with localized hepatocellular carcinoma or hepatocellular carcinoma within Milan criteria at time of diagnosis

	Localized HCC at Time of diagnosis			HCC within Milan criteria at time of diagnosis
	Percent (%)	Frequency (n)	P-value	Percent (%)	Frequency (n)	P-value
Total	54	6091		38	5103
Sex
Female	57.6	1680	< 0.001	39.7	1422	0.01
Male	52.8	4411		37.4	3681
Age
< 50 yr	51.7	630	< 0.01	36.8	530	< 0.001
50-64 yr	55.5	3030		44.6	2820
> 65 yr	52.9	2431		30.9	2753
Insurance
Medicare or Commercial	56.2	3004	< 0.001	42.7	2547	< 0.001
Medicaid	53.8	1607		42.9	1407
Uninsured	39.4	191		29.9	164
Year of Diagnosis
2004-2006	52.8	1195	< 0.001	33.4	908	< 0.001
2007-2008	31.7	553		33.8	714
2009-2010	52.7	1368		37.3	951
2011-2012	56.3	1368		40.9	1173
2013-2014	56.9	1525		42.6	1357

HCC: Hepatocellular carcinoma.

Table 3 Trends in the proportion of Hispanic hepatocellular carcinoma patients with localized hepatocellular carcinoma and hepatocellular carcinoma within Milan criteria over time

Localized HCC	Overall		Female		Male		Age < 50		Age 50-64		Age 65 and over		Uninsured		Medicaid		Medicare/Commercial
	%	n	%	n	%	n	%	n	%	n	%	n	%	n	%	n	%	n
2004-2006	52.8	1195	58	342	51	853	48.7	165	54.1	544	52.9	486	-	-	-	-	-	-
2007-2008	31.7	553	55.5	236	48.1	635	46	115	50.9	424	50.1	332	33.9	38	49.3	281	52.1	531
2009-2010	52.7	1368	55.3	588	51.8	844	51.5	121	55.4	589	49.6	422	36	40	52.6	397	54.4	675
2011-2012	56.3	1368	58	363	55.7	1005	60.2	121	57.5	706	54.1	541	39.6	53	56.4	456	58	835
2013-2014	56.9	1525	59.7	451	55.7	1074	56	108	57.6	767	56.1	650	46.9	60	55.5	473	58.4	963
P-Value		< 0.001		< 0.03		<0.001		< 0.02		< 0.02		< 0.01		0.17		0.14		< 0.001
HCC Within Milan	Overall		Female		Male		Age < 50		Age 50-64		Age 65 and Over		Uninsured		Medicaid		Medicare/Commercial
	%	n	%	n	%	n	%	n	%	n	%	n	%	n	%	n	%	n
2004-2006	33.4	908	34.6	255	34.3	653	32.9	141	39.9	462	26.4	305	-	-	-	-	-	-
2007-2008	33.8	714	32.8	179	35.5	535	34.1	105	40.6	397	25.2	212	27.5	36	37.8	237	37.6	428
2009-2010	37.3	951	40.6	260	35.3	691	36.2	97	45.5	559	28.2	295	30.3	37	40.1	337	40.4	558
2011-2012	40.9	1173	41.1	310	40.2	863	40.8	92	47.7	676	33.1	405	30.7	47	47.5	420	42.4	687
2013-2014	42.6	1357	46.1	418	36.8	939	41.2	95	47.1	726	30.9	536	30.8	44	44.2	413	47.8	874
P-Value		< 0.001		< 0.001		< 0.001		0.3		< 0.001		< 0.001		0.92		< 0.001		< 0.001

HCC: Hepatocellular carcinoma.