High burden of hepatocellular carcinoma and viral hepatitis in Southern and Central Vietnam: Experience of a large tertiary referral center, 2010 to 2016

Table 1 Percentage distribution of demographic and disease characteristics of patients with primary hepatocellular carcinoma at Cho Ray Hospital, Ho Chi Minh City, Vietnam, 2010 to 2016

Characteristic	2010 (n = 2793)	2011 (n = 3111)	2012 (n = 3349)	2013 (n = 3471)	2014 (n = 3494)	2015 (n = 3804)	2016 (n = 4069)	Total (n = 24091)	P value
Male gender	82.6	82.77	82.23	80.44	81.2	81.2	82.13	81.76	0.17
Age (yr)
≤ 40	10.31	8.94	9.14	8.58	7.76	7.6	7.77	8.49	< 0.0001
41-50	19.3	18.58	17.44	17.26	17.32	17.43	16.76	17.64
51-60	30.68	30.57	29.23	30.83	29.28	29.86	29.29	29.92
61-70	21.48	22.6	24.37	23.22	26.24	26.63	27.89	24.86
> 70	18.22	19.32	19.83	20.11	19.4	18.48	18.28	19.08
Advanced disease stage	40.57	43.68	40.52	37.65	40.78	40.75	41.68	40.79	0.76
HBsAg and anti-HCV testing available (n)1	n = 2505	n = 2405	n = 2773	n = 3153	n = 3225	n = 3616	n = 3907	n = 21584	< 0.0001
HBV infection	61.72	69.94	66.35	60.1	59.69	60.87	60.23	62.28
HCV infection	24.79	27.32	28.96	25.06	27.13	25.06	24.98	26
HBV and HCV coinfection	2.71	2.74	2.52	3.04	2.95	2.41	2.46	2.68
Non-HBV or HCV liver disease	10.78	0	2.16	11.8	10.23	11.67	12.34	8.97

¹HBV infection defined as positive HbSAg level. HCV infection defined as positive HCV antibody level. HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; HCV: Hepatitis C virus.

Table 2 Distribution of serum alpha-fetoprotein levels in patients with hepatocellular carcinoma, 2010 to 2016

AFP level (ng/mL)	2010 (n = 2793)	2011 (n = 3111)	2012 (n = 3349)	2013 (n = 3471)	2014 (n = 3494)	2015 (n = 3804)	2016 (n = 4069)	Total (n = 24091)
< 20	23.24	22.53	21.59	26.22	22.41	22.32	23.99	23.21
> 20-100	15.43	14.14	15.17	13.71	15.00	14.54	14.48	14.62
> 100-200	6.30	5.37	5.11	5.36	6.70	6.34	6.41	5.96
> 200-400	5.87	5.63	5.32	5.30	5.38	5.81	5.97	5.62
> 400	47.65	50.50	50.82	46.99	48.20	49.50	47.53	48.72
Not recorded	1.50	1.83	2.00	2.42	2.32	1.5	1.62	1.88

P value for trend = 0.33. AFP: Alpha-fetoprotein.