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Contents Volume 17 Issue 6 June 27, 2025

Review

Gut microbiota in non-alcoholic fatty liver disease: Pathophysiology, diagnosis, and therapeutics

Himani Pandey, Prabudh Goel, Varunvenkat M Srinivasan, Daryl W T Tang, Sunny H Wong, Devi Lal

World J Hepatol 17(6):106849. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.106849

Abstract (280) | Core Tip (323) | Full Article (HTML) (3963) | Figures (1-2) (207) | Tables (1-3) (283) | Full Article (PDF)-6131K (263) | Full Article with Cover (PDF)-6362K (374) | Full Article (XML)-880K (85) | Audio-677K (10) | Peer-Review Report-270K (69) | Answering Reviewers-147K (64) | Received: 03/08/2025 | Revised: 03/25/2025 | Accepted: 05/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (11) | Total Visits (7147) | Similar Articles (383) | Timeline of Article Publication (1) | Authors Evaluation (2) | Article Quality Tracking (1) | Cite |

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Oncohepatology: Navigating liver injury in the era of modern cancer therapy

Shuo-Feng Li, Xu Ouyang, Shi Feng, Ming-Zhong Wan, Kai-Nan Zhou, Bo-Yuan Wen, Yu-Ze Yin, Hang Yi, Xin-Yuan Chen

World J Hepatol 17(6):106932. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.106932

Abstract (257) | Core Tip (242) | Full Article (HTML) (1530) | Figures (1-1) (209) | Tables (1-1) (224) | Full Article (PDF)-917K (108) | Full Article with Cover (PDF)-1150K (96) | Full Article (XML)-209K (67) | Audio-495K (56) | Peer-Review Report-216K (52) | Answering Reviewers-97K (59) | Received: 03/14/2025 | Revised: 04/24/2025 | Accepted: 06/03/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (6) | Total Visits (4551) | Similar Articles (71) | Timeline of Article Publication (0) | Cite |

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Minireviews

Hepatocyte-intrinsic innate immunity in hepatitis B virus infection: A focused review

Ping Chen, Jing Zhao, Ning-Kai Chen, Zhi-Ying Chen

World J Hepatol 17(6):104533. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.104533

Abstract (246) | Core Tip (260) | Full Article (HTML) (1296) | Figures (1-1) (226) | Tables (1-1) (198) | Full Article (PDF)-1753K (188) | Full Article with Cover (PDF)-1986K (126) | Full Article (XML)-182K (62) | Audio-180K (14) | Peer-Review Report-254K (56) | Answering Reviewers-376K (49) | Received: 12/24/2024 | Revised: 04/17/2025 | Accepted: 06/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (3807) | Similar Articles (387) | Timeline of Article Publication (0) | Cite |

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Advances in the diagnosis and management of clinically significant portal hypertension in cirrhosis: A narrative review

Xiao-Yu Xie, Amine Benmassaoud

World J Hepatol 17(6):104761. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.104761

Abstract (228) | Core Tip (295) | Full Article (HTML) (3616) | Figures (1-7) (252) | Tables (1-2) (263) | Full Article (PDF)-4291K (382) | Full Article with Cover (PDF)-4521K (188) | Full Article (XML)-248K (91) | Audio-595K (33) | Peer-Review Report-484K (101) | Answering Reviewers-30K (96) | Received: 01/08/2025 | Revised: 04/09/2025 | Accepted: 05/18/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (7) | Total Visits (6576) | Similar Articles (452) | Timeline of Article Publication (0) | Cite |

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Hope on the horizon: Emerging therapies for hepatitis D

Zaigham Abbas, Minaam Abbas

World J Hepatol 17(6):107963. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.107963

Abstract (270) | Core Tip (229) | Full Article (HTML) (2013) | Figures (1-1) (199) | Tables (1-1) (191) | Full Article (PDF)-4833K (176) | Full Article with Cover (PDF)-5065K (107) | Full Article (XML)-124K (65) | Audio-479K (22) | Peer-Review Report-260K (72) | Answering Reviewers-511K (61) | Received: 04/01/2025 | Revised: 04/22/2025 | Accepted: 06/07/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (4385) | Similar Articles (13) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

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Retrospective Cohort Study

Long-term outcomes of early transjugular intrahepatic portosystemic shunts in patients with acute variceal bleeding and cirrhosis

Xin Tang, Ju-Bo Liang, Chen Wang, Jia-Li Ma, Rong-Rong Jia, Yu-Gang Wang, Min Shi

World J Hepatol 17(6):105578. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.105578

Abstract (224) | Core Tip (225) | Full Article (HTML) (775) | Figures (1-2) (181) | Tables (1-4) (206) | Full Article (PDF)-673K (96) | Full Article with Cover (PDF)-905K (93) | Full Article (XML)-111K (62) | Audio-826K (23) | Peer-Review Report-224K (71) | Answering Reviewers-64K (61) | Received: 02/14/2025 | Revised: 04/12/2025 | Accepted: 05/16/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (3256) | Similar Articles (281) | Timeline of Article Publication (5) | Authors Evaluation (2) | Cite |

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Diagnostic performance of Liver FibraChek Dx^©, a blood-based test for the non-invasive detection of liver cirrhosis and cancer

Fernando Siguencia, Michitaka Matsuda, Vijay Pandyarajan, Sunao Tanaka, Steven M Smith, Catherine Bresee, Ekihiro Seki, Charles J Rosser, Hideki Furuya

World J Hepatol 17(6):106481. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.106481

Abstract (226) | Core Tip (224) | Full Article (HTML) (1048) | Figures (1-2) (184) | Tables (1-3) (190) | Full Article (PDF)-1055K (104) | Full Article with Cover (PDF)-1287K (84) | Full Article (XML)-95K (54) | Audio-341K (7) | Peer-Review Report-255K (57) | Answering Reviewers-53K (57) | Supplementary Material-175K (55) | Received: 02/26/2025 | Revised: 04/24/2025 | Accepted: 05/29/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (3578) | Similar Articles (272) | Timeline of Article Publication (0) | Cite |

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Association between insulin and liver function tests, liver disease and cirrhosis in population-based cohorts with long term follow-up

Andreas Schult, Kirsten Mehlig, Kurt Svärdsudd, Sven Wallerstedt, Cecilia Björkelund, Per-Olof Hansson, Henrik Zetterberg, Jerzy Kaczynski

World J Hepatol 17(6):107160. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.107160

Abstract (243) | Core Tip (239) | Full Article (HTML) (885) | Figures (1-3) (187) | Tables (1-3) (197) | Full Article (PDF)-2075K (103) | Full Article with Cover (PDF)-2307K (151) | Full Article (XML)-134K (64) | Audio-382K (10) | Peer-Review Report-230K (52) | Answering Reviewers-49K (53) | Supplementary Material-139K (61) | Received: 03/16/2025 | Revised: 04/08/2025 | Accepted: 05/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (3579) | Similar Articles (47) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

Comparison between short-course and long-course antimicrobial treatments for acute cholangitis with gram-positive coccus bacteremia after endoscopic retrograde cholangiopancreatography

Yuntae Kim, Kazuhiro Ishikawa, Kenji Nakamura, Hikaru Ikusaka, Ryohsuke Yokosuka, Tomohiro Yamazaki, Yuichiro Suzuki, Shuhei Okuyama, Koichi Takagi, Katsuyuki Fukuda

World J Hepatol 17(6):108100. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.108100

Abstract (246) | Core Tip (222) | Full Article (HTML) (1664) | Figures (1-1) (198) | Tables (1-2) (194) | Full Article (PDF)-551K (103) | Full Article with Cover (PDF)-784K (61) | Full Article (XML)-97K (62) | Audio-554K (10) | Peer-Review Report-220K (54) | Answering Reviewers-140K (61) | Received: 04/04/2025 | Revised: 04/24/2025 | Accepted: 05/26/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (4244) | Similar Articles (188) | Timeline of Article Publication (0) | Cite |

(0) | (0) | (0) | (0) | Open

Retrospective Study

Sex-related differences in patients with chronic hepatitis C infection treated with direct-acting antiviral drugs

Krystyna Dobrowolska, Dorota Zarębska-Michaluk, Malgorzata Pawłowska, Magdalena Tudrujek-Zdunek, Beata Lorenc, Hanna Berak, Ewa Janczewska, Włodzimierz Mazur, Justyna Janocha-Litwin, Jakub Klapaczyński, Marek Sitko, Dorota Dybowska, Anna Parfieniuk-Kowerda, Anna Piekarska, Jerzy Jaroszewicz, Robert Flisiak

World J Hepatol 17(6):105899. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.105899

Abstract (228) | Core Tip (230) | Full Article (HTML) (924) | Figures (1-2) (197) | Tables (1-4) (189) | Full Article (PDF)-1209K (117) | Full Article with Cover (PDF)-1441K (192) | Full Article (XML)-181K (59) | Audio-321K (11) | Peer-Review Report-246K (52) | Answering Reviewers-126K (61) | Received: 02/09/2025 | Revised: 04/18/2025 | Accepted: 05/24/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (4) | Total Visits (4853) | Similar Articles (98) | Timeline of Article Publication (0) | Cite |

(0) | (0) | (0) | (0) | Open

Observational Study

MANPOWER study: Real-world post-hoc analysis assessing essential phospholipids for non-alcoholic fatty liver disease from the Russian registry

Asad Izziddin Dajani, Branko Popovic, Caroline Amand, Sabine Tong, Kirill Maximovich Starostin, Victor Goncharuk

World J Hepatol 17(6):103217. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.103217

Abstract (242) | Core Tip (270) | Full Article (HTML) (2004) | Figures (1-4) (195) | Tables (1-1) (193) | Full Article (PDF)-2352K (126) | Full Article with Cover (PDF)-2582K (94) | Full Article (XML)-119K (72) | Audio-1043K (36) | Peer-Review Report-242K (65) | Answering Reviewers-141K (83) | Supplementary Material-96K (71) | Received: 11/12/2024 | Revised: 03/10/2025 | Accepted: 05/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (4913) | Similar Articles (229) | Timeline of Article Publication (0) | Cite |

(0) | (0) | (0) | (0) | Open

Relationship between glucagon and metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes mellitus

Yi Sun, Ping Huang, Xiao-Qin Zhao, Zhu-Qi Tang, Tong-Tong Xu, Xin-Wei Wang, Zong-Xian Qi, Wei-Rong Lin, Min-You Li, Yun-Juan Gu

World J Hepatol 17(6):104693. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.104693

Abstract (219) | Core Tip (231) | Full Article (HTML) (968) | Figures (1-1) (176) | Tables (1-5) (210) | Full Article (PDF)-625K (135) | Full Article with Cover (PDF)-857K (87) | Full Article (XML)-118K (81) | Audio-1286K (17) | Peer-Review Report-249K (67) | Answering Reviewers-157K (61) | Received: 12/30/2024 | Revised: 03/18/2025 | Accepted: 05/26/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (3518) | Similar Articles (262) | Timeline of Article Publication (0) | Cite |

(0) | (0) | (0) | (0) | Open

Dietary ω-3 polyunsaturated fatty acid intake improves skeletal muscle mass in patients with metabolic dysfunction-associated fatty liver disease: A nationwide cross-sectional study

Li-Zhan Bie, Chao Wu, Jia-Lu Wang

World J Hepatol 17(6):107931. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.107931

Abstract (245) | Core Tip (257) | Full Article (HTML) (1066) | Figures (1-2) (192) | Tables (1-4) (203) | Full Article (PDF)-648K (105) | Full Article with Cover (PDF)-881K (83) | Full Article (XML)-103K (64) | Audio-142K (11) | Peer-Review Report-203K (61) | Answering Reviewers-178K (61) | Received: 03/31/2025 | Revised: 04/22/2025 | Accepted: 06/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (4735) | Similar Articles (27) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

Correlation between gynecomastia and endocrine regulation in patients with metabolic dysfunction-associated fatty liver disease: A cross-sectional study

Ming-Huang Zhang, Ning Meng, Kang-Hui Zhang, Jun-Kang Yu, Chen-Hao Huang, Shu Yang, Ding-Yi Zhu

World J Hepatol 17(6):108096. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.108096

Abstract (229) | Core Tip (234) | Full Article (HTML) (1500) | Figures (1-3) (185) | Tables (1-5) (207) | Full Article (PDF)-20979K (135) | Full Article with Cover (PDF)-21207K (80) | Full Article (XML)-174K (89) | Audio-713K (12) | Peer-Review Report-483K (84) | Answering Reviewers-811K (85) | Received: 04/04/2025 | Revised: 05/06/2025 | Accepted: 05/28/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (5627) | Similar Articles (27) | Timeline of Article Publication (0) | Authors Evaluation (3) | Cite |

(0) | (0) | (0) | (0) | Open

Basic Study

Effect of rapamycin nanoparticles in an animal model of primary biliary cholangitis

Yu-Shu Yang, Xian-Rui Li, Zhi-Min Wang, Lin Zheng, Jin-Long Li, Xiao-Lin Cui, Yan-Biao Song, Jun-Ji Ma, Hui-Fang Guo, Li-Xia Gao, Xiao-Hui Zhou

World J Hepatol 17(6):104073. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.104073

Abstract (228) | Core Tip (250) | Full Article (HTML) (934) | Figures (1-5) (207) | Full Article (PDF)-3079K (109) | Full Article with Cover (PDF)-3312K (88) | Full Article (XML)-104K (59) | Audio-925K (12) | Peer-Review Report-242K (60) | Answering Reviewers-71K (48) | Received: 12/15/2024 | Revised: 02/24/2025 | Accepted: 05/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (3485) | Similar Articles (59) | Timeline of Article Publication (1) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

Machine learning to identify potential biomarkers for sarcopenia in liver cirrhosis

Qian-Yu Liang, Jun Wang, Yun-Feng Yang, Kai Zhao, Rui-Li Luo, Ye Tian, Feng-Xia Li

World J Hepatol 17(6):105332. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.105332

Abstract (256) | Core Tip (266) | Full Article (HTML) (962) | Figures (1-4) (180) | Tables (1-1) (178) | Full Article (PDF)-3319K (113) | Full Article with Cover (PDF)-3552K (109) | Full Article (XML)-109K (62) | Audio-6215K (12) | Peer-Review Report-469K (75) | Answering Reviewers-128K (69) | Supplementary Material-62K (67) | Received: 01/18/2025 | Revised: 03/30/2025 | Accepted: 04/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (3809) | Similar Articles (565) | Timeline of Article Publication (0) | Cite |

(0) | (0) | (0) | (0) | Open

Chromatin accessibility module identified by single-cell sequencing underlies the diagnosis and prognosis of hepatocellular carcinoma

Xiao-Li Xi, Yi-Dong Yang, Hui-Ling Liu, Jie Jiang, Bin Wu

World J Hepatol 17(6):107329. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.107329

Abstract (222) | Core Tip (238) | Full Article (HTML) (1153) | Figures (1-7) (279) | Full Article (PDF)-8698K (172) | Full Article with Cover (PDF)-8927K (81) | Full Article (XML)-173K (71) | Audio-309K (13) | Peer-Review Report-359K (61) | Answering Reviewers-267K (79) | Supplementary Material-1226K (66) | Received: 03/20/2025 | Revised: 04/24/2025 | Accepted: 05/29/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (5196) | Similar Articles (1880) | Timeline of Article Publication (2) | Cite |

(0) | (0) | (0) | (0) | Open

Meta-Analysis

Human albumin infusion for reducing hyponatremia and circulatory dysfunction in liver cirrhosis: A meta-analysis update

Hui-Juan Zhou, Zi-Qiang Li, Da-Er Dili, Qing Xie

World J Hepatol 17(6):106418. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.106418

Abstract (239) | Core Tip (267) | Full Article (HTML) (1862) | Figures (1-3) (206) | Tables (1-1) (210) | Full Article (PDF)-2462K (158) | Full Article with Cover (PDF)-2695K (159) | Full Article (XML)-192K (68) | Audio-248K (35) | Peer-Review Report-327K (64) | Answering Reviewers-192K (57) | Supplementary Material-11333K (69) | Received: 02/26/2025 | Revised: 04/15/2025 | Accepted: 06/03/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (4638) | Similar Articles (189) | Timeline of Article Publication (2) | Cite |

(0) | (0) | (0) | (0) | Open

Case Report

Adult presentation of Shwachman-Diamond syndrome complicated by liver cirrhosis and pancreatic fat infiltration: A case report

Hai-Jun Guo

World J Hepatol 17(6):108558. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.108558

Abstract (264) | Core Tip (222) | Full Article (HTML) (935) | Figures (1-2) (175) | Full Article (PDF)-3083K (136) | Full Article with Cover (PDF)-3316K (78) | Full Article (XML)-52K (57) | Audio-4795K (11) | Peer-Review Report-499K (72) | Answering Reviewers-2556K (68) | Received: 04/17/2025 | Revised: 05/13/2025 | Accepted: 05/29/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (3235) | Similar Articles (4822) | Timeline of Article Publication (1) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

Letter to the Editor

Silent sabotage: How hepatitis B virus-miR-3 disarms innate immunity through cGAS-STING suppression

Nida Ansari, Patrick Twohig

World J Hepatol 17(6):106493. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.106493

Abstract (258) | Core Tip (269) | Full Article (HTML) (763) | Full Article (PDF)-355K (83) | Full Article with Cover (PDF)-589K (80) | Full Article (XML)-29K (62) | Audio-282K (14) | Peer-Review Report-245K (65) | Answering Reviewers-155K (64) | Received: 02/27/2025 | Revised: 03/30/2025 | Accepted: 04/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2669) | Similar Articles (211) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

Role of zinc finger protein 71 in hepatocellular carcinoma: Methodological concerns, clinical relevance, and future directions

Arunkumar Krishnan, Diptasree Mukherjee

World J Hepatol 17(6):106573. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.106573

Abstract (266) | Core Tip (220) | Full Article (HTML) (516) | Full Article (PDF)-381K (78) | Full Article with Cover (PDF)-615K (79) | Full Article (XML)-63K (62) | Audio-243K (8) | Peer-Review Report-225K (54) | Answering Reviewers-42K (71) | Received: 02/28/2025 | Revised: 04/15/2025 | Accepted: 05/13/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2190) | Similar Articles (1880) | Timeline of Article Publication (0) | Cite |

(0) | (0) | (0) | (0) | Open

Future directions in prognostic modeling for dengue-induced severe hepatitis

Chen Wang, Hong Hu, Yun Song, Yu-Gang Wang, Min Shi

World J Hepatol 17(6):107299. Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.107299

Abstract (230) | Core Tip (223) | Full Article (HTML) (715) | Full Article (PDF)-393K (110) | Full Article with Cover (PDF)-624K (89) | Full Article (XML)-69K (66) | Audio-2158K (10) | Peer-Review Report-231K (61) | Answering Reviewers-70K (56) | Received: 03/21/2025 | Revised: 04/06/2025 | Accepted: 04/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (2418) | Similar Articles (65) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

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