Circulating microRNAs in patients with non-alcoholic fatty liver disease

Figure 1 Box plots showing the expression value of 8 genes between control and non-alcoholic fatty liver disease groups. The middle line indicates the median statistic, the bottom and top of the box show the 25^th and 75^th percentiles, the lower and upper whiskers show the minimum and maximum values of the data after detecting outliers (circles). P values were obtained from a two-sided t test and adjusted with false discovery rate. NAFLD: Non-alcoholic fatty liver disease.

Figure 2 A cluster heatmap displaying the data values of samples and differentially expressed miRNAs simultaneously in a hierarchical cluster structure. Bright red: Under-expression; black: No change; bright green: Over-expression.

Figure 3 Comparison of area under receiver operating characteristic curve values of miR-197, mir-146b, mir-181d and mir-99a miRNA’s in the detection of non-alcoholic fatty liver disease. Area under receiver operating characteristic values were 0.77 (0.60-0.88), 0.75 (0.59-0.87), 0.86 (0.72-0.95), and 0.76 (0.60-0.88), respectively, and there was no statistically significant difference between any two miRNAs (P > 0.05).