Lipid lowering effects of iodothyronines: In vivo and in vitro studies on rat liver

Figure 1 The chemical structures of three biologically active iodothyronines and one derivative: thyroxine, 3,3’,5-triiodothyronine, 3,5-diiodothyronine and 3-iodothyronamine. T4: Thyroxine; T3: 3,3’,5-triiodothyronine; T2: 3,5-diiodothyronine; T1AM: 3-iodothyronamine.

Figure 2 Schematic representation of the mechanisms underlying the control of lipid metabolism by iodothyronines in the hepatic cell: A summary of the possible signaling pathways involved in iodothyronine actions is presented. The classic “receptor-mediated” pathway describes the action of iodothyronines through the thyroid hormone receptors (TR). The “non receptor-mediated” pathway occurs through the interaction of iodothyronines with different cellular targets. FFA: Free fatty acids; LD: Lipid droplet; AOX: Acyl-CoA oxidase; ATGL: Adipose triglyceride lipase; CPT: Carnitine palmitoyl-transferase 1; FAS: fatty acid synthase.