Prognostic value of dynamic changes in C-reactive protein to albumin ratio in patients with acute-on-chronic liver failure

Figure 1 Flow diagram of patient enrollment. ACLF: Acute-on-chronic liver failure.

Figure 2 Temporal trajectories of C-reactive protein to albumin ratio values and predictive power of dynamic changes in C-reactive protein to albumin ratio for 28-day mortality. A: Temporal trajectories of C-reactive protein to albumin ratio (CAR) values during the first 14 days of hospitalization; B: Predictive power of dynamic changes in CAR for 28-day mortality. CAR: C-reactive protein to albumin ratio; AUC: Area under the receiver operating characteristic curve.

Figure 3 Discrimination performance and risk stratification power of the Chinese Group on Study of Severe Hepatitis B-C-reactive protein to albumin ratio model. A: Receiver operating characteristic curves comparing the Chinese Group on Study of Severe Hepatitis B-C-reactive protein to albumin ratio (COSSH-CAR) model with established prognostic scores for predicting 28-day mortality; B: Kaplan-Meier survival curves for patients stratified into low, intermediate and high-risk groups based on COSSH-CAR scores. ROC: Receiver operating characteristic; COSSH-CAR: Chinese Group on Study of Severe Hepatitis B-C-reactive protein to albumin ratio; AUC: Area under the receiver operating characteristic curve; MELD: Model for end-stage liver disease; MELD-Na: Model for end-stage liver disease-sodium.

Figure 4 Calibration curves for the Chinese Group on Study of Severe Hepatitis B-C-reactive protein to albumin ratio model. A: 28-day mortality calibration; B: 90-day mortality calibration. Diagonal dashed lines represent perfect calibration.

Figure 5 Subgroup analysis of the performance of the Chinese Group on Study of Severe Hepatitis B-C-reactive protein to albumin ratio model according to etiology and precipitating event. COSSH-CAR: Chinese Group on Study of Severe Hepatitis B-C-reactive protein to albumin ratio; AUC: Area under the receiver operating characteristic curve.