Drug development for chronic hepatitis B functional cure: Recent progress

Figure 1 Overview of chronic hepatitis B drug therapy targets[18]. This diagram illustrates the life cycle of hepatitis B virus (HBV), including viral entry, uncoating, formation of relaxed circular DNA, formation of covalently closed circular DNA, integration of genomic DNA, transcription, and translation. It also describes various therapeutic strategies targeting different stages of the HBV life cycle, including entry inhibitors, immunomodulators, and inhibitors that directly target viral DNA and RNA. This figure was created by BioRender.com (Supplementary material). cccDNA: Covalently closed circular DNA; rcDNA: Relaxed circular DNA; ASO: Antisense oligonucleotide; HBsAg: Hepatitis B surface antigen; CAM: Capsid modulators; mRNA: Messenger RNA; pgRNA: Pre-genomic RNA.