Hepatitis C resistance to NS5A inhibitors: Is it going to be a problem?

Figure 1 NS5A resistance-associated substitution testing in NS5A inhibitor-naïve patients prior to treatment with NS5A inhibitor-containing regimen. A: Standard treatment strategy and outcome without NS5A resistance-associated substitution (RAS) testing; B: Optimized treatment strategy and outcome with NS5A RAS testing. The implementation of NS5A RAS testing is developed by decision-making based on the presence of RAS > 100X. SVR: Sustained virologic response.

Figure 2 NS5A resistance-associated substitution testing in NS5A inhibitor-experienced patients prior to retreatment with NS5A inhibitor-containing regimen. Optimized treatment strategy with NS5A resistance-associated substitutions (RAS) testing and the outcome is shown. The implementation of NS5A RAS testing is developed by decision-making based on the presence of RAS > 100X. SVR: Sustained virologic response.