Tao XM, Zeng MH, Zhao YF, Han JX, Mi YQ, Xu L. Direct-acting antivirals failed to reduce the incidence of hepatocellular carcinoma occurrence in hepatitis C virus associated cirrhosis: A real-world study. World J Hepatol 2024; 16(1): 41-53 [PMID: 38313240 DOI: 10.4254/wjh.v16.i1.41]
Reader's ID:
07739628
Submitted on:
February 04, 2024, 20:43
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Reader Comments:
occurrence in hepatitis C virus associated cirrhosis: A real-world study” has been read enthusiastically. I wholeheartedly congratulate the authors on their well-written article. The topic is of interest to the scientific audience of the journal and the article is coherent, with a logical progression of ideas from one section to the next. However, I would like to highlight a few points, which I believe would not only be helpful to the readers but also highlight avenues for future research.
First, the retrospective design of the study makes it subject to bias, thus questioning the credibility of its results. Second, the modest sample size (only 427 patients) is an important limitation of this study which should have been mentioned in the limitations section. Third, excluding patients less than 18 years of age puts the credibility of the study findings into question. Fourth, The study enrolled only the patients admitted in the hospital. The authors should have provided an explanation for excluding patients in ambulatory settings. Last, although the authors mentioned that the data on Body mass index (BMI) were collected, they didn’t report it in the baseline characteristics table. Large multicenter prospective studies are needed to validate the results of this study.
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