Cao L, Zhu YQ, Wu ZX, Wang GX, Cheng HW. Engineering nanotheranostic strategies for liver cancer. World J Gastrointest Oncol 2021; 13(10): 1213-1228 [PMID: 34721763 DOI: 10.4251/wjgo.v13.i10.1213]
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October 19, 2021, 06:38
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Reader Comments:
It is interesting to provide a nanotechnology-based solution for the treatment of liver cancer from the perspective of a carrier, and it also has been very beneficial to provide other information about applicable therapeutic regimens.
Reply from the Editorial Office:
Thank you very much for your comments.
Author's Reply:
Replied on July 04, 2022, 03:19
Thank you for your positive comments.
Reader's ID:
00505755
Submitted on:
October 18, 2021, 00:39
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Reader Comments:
This is a nice review paper on engineering nanotechnology.
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Thank you very much for your comments.
Author's Reply:
Replied on October 18, 2021, 02:03
Dear reader,
Thank you for your positive comments, and we welcome further discussion with you.
Best regards,
Hongwei Cheng
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02687374
Submitted on:
October 17, 2021, 13:38
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Reader Comments:
This frontier focuses on the prominent problems in the clinical treatment of liver cancer, especially in the discussion of key factors that restrict the early diagnosis and create a poor prognosis of liver cancer, and further explores nanotechnology-based solutions. Authors brought out the conclusion that the specific structure of many nanotheranostic strategies improves the performance of combination therapy, which significantly improves the prognosis of liver cancer patients and prolongs survival. This article is clear and well-organized, with appropriate expositions, and both illustrations and texts. However, I still have a problem.Please explain why the higher estimated death rate than the estimated incidence rate can indicate unsatisfactory clinical practice of liver cancer? Are mortality and morbidity comparable?
Reply from the Editorial Office:
Thank you very much for your comments.
Author's Reply:
Replied on October 18, 2021, 02:01
Dear reader,
Thank you for your attention, just as you presented, the higher estimated death rate than the estimated incidence is the comparison between mortality and morbidity.
Best regards,
Hongwei Cheng
Reader's ID:
06083007
Submitted on:
October 14, 2021, 14:51
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Reader Comment Standards for Published Articles:
1 Title
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2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
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9 Biostatistics
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11 References
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Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
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Language quality (style, grammar, and spelling) should be evaluated and classified according to the following five categories.
Reader Comments:
This article has tried to discuss the prominent problems in the clinical treatment of liver cancer, especially in the discussion of key factors that restrict the early diagnosis and create a poor prognosis of liver cancer, and further explores nanotechnology-based solutions. Authors brought out the conclusion that development of the engineering nanotheranostic strategy could revolutionize the current treatment of liver cancer. However, the evidence they provided seems not strong enough to support their conclusion.
1.Authors mentioned in the manuscript that “However, clinical trials of programmed death-1 (PD-1) monoclonal antibody therapy in patients with advanced hepatocellular carcinoma did not improve overall survival or progression-free survival of patients”. But truth is “lenvatinib plus pembrolizumab” has been approved for 1st line treatment of unresectable advance HCC based on improved OS and PFS in clinical trial. Similar results have been staying in Atezolizumab + Bevacizumab.(Please check Keynote-524 and CheckMate-040 ).
2.More clinical trials of therapeutic strategy using nano-delivery-Technology should be added in for making “development of the engineering nanotheranostic strategy could revolutionize the current treatment of liver cancer” look more promising.
3. English should be improved.
Reply from the Editorial Office:
First, thank you very much for your professional comments on the article published in World Journal of Gastrointestinal Oncology.
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