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Wang H, Qin Y, Niu J, Chen H, Lu X, Wang R, Han J. Evolving perspectives on evaluating obesity: from traditional methods to cutting-edge techniques. Ann Med 2025; 57:2472856. [PMID: 40077889 PMCID: PMC11912248 DOI: 10.1080/07853890.2025.2472856] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/14/2024] [Revised: 02/09/2025] [Accepted: 02/12/2025] [Indexed: 03/14/2025] Open
Abstract
Objective: This review examines the evolution of obesity evaluation methods, from traditional anthropometric indices to advanced imaging techniques, focusing on their clinical utility, limitations, and potential for personalized assessment of visceral adiposity and associated metabolic risks. Methods: A comprehensive analysis of existing literature was conducted, encompassing anthropometric indices (BMI, WC, WHR, WHtR, NC), lipid-related metrics (LAP, VAI, CVAI, mBMI), and imaging technologies (3D scanning, BIA, ultrasound, DXA, CT, MRI). The study highlights the biological roles of white, brown, and beige adipocytes, emphasizing visceral adipose tissue (VAT) as a critical mediator of metabolic diseases. Conclusion: Although BMI and other anthropometric measurements are still included in the guidelines, indicators that incorporate lipid metabolism information can more accurately reflect the relationship between metabolic diseases and visceral obesity. At the same time, the use of more modern medical equipment, such as ultrasound, X-rays, and CT scans, allows for a more intuitive assessment of the extent of visceral obesity.
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Affiliation(s)
- Heyue Wang
- Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
| | - Yaxin Qin
- Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
| | - Jinzhu Niu
- Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
| | - Haowen Chen
- Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
| | - Xinda Lu
- Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
| | - Rui Wang
- Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
| | - Jianli Han
- Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
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Zhang B, Gu Y, Li Y, Feng X. Prediction of testosterone deficiency using different screening indexes in adult American men: An NHANES cross-sectional study. PLoS One 2025; 20:e0323900. [PMID: 40489567 DOI: 10.1371/journal.pone.0323900] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/04/2024] [Accepted: 04/15/2025] [Indexed: 06/11/2025] Open
Abstract
BACKGROUND Testosterone levels are closely associated with visceral obesity, insulin resistance, and lipid metabolism. The objective of this study was to investigate the associations among eight indicators related to visceral obesity, insulin resistance, lipid metabolism, and testosterone levels. METHODS The data were obtained from a cross-sectional survey based on National Health and Nutrition Examination Survey (NHANES) 2013-2016. Logistic and linear regression were employed to assess the associations between these inicators and testosterone levels. Simultaneously, the receiver operating characteristic (ROC) curve was utilized to evaluate their predictive capacity for testosterone deficiency (TD). RESULTS Data from a collective of 1514 individuals selected from NHANES were analyzed. After adjusting all potential confounders, a tight association was identified between these eight indexes and TD. The ROC curve analysis showed that the triglyceride-glucose waist-to-height ratio (TyG-WHtR)is the best predictor of testosterone deficiency (AUC: 0.7760, 95%CI: 0.7460-0.8060), with a cut-off value of 5.375. Further analyses indicated that participants with higher TyG-WHtR index exhibitrd a lower total testosterone level(β: -79.36,95%CI: -105.90, -52.82). Additionally, males in TyG-WHtR index tertile 3 had a higher risk of TD (OR: 6.61, 95%CI: 2.90,15.07), and lower total testosterone levels (β: -121.9, 95%CI: -186.82, -56.98). All the results remained stable in the subgroup analyses stratified by diabetes and hypertension. CONCLUSIONS We found that these indexses are tightly associated with testosterone levels in U.S. adult men. Moreover, the TyG-WHtR index demonstrates the most effective predictive performance in the population. However, more well-designed studies are still needed to validate their association.
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Affiliation(s)
- Bo Zhang
- Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
- Department of Urology, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China
| | - Yi Gu
- Department of Breast Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
| | - Yuanyuan Li
- Department of General Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
| | - Xingliang Feng
- Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
- Department of Urology, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China
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Sasaki N, Ueno Y, Ozono R, Nakano Y, Higashi Y. Insulin resistance in adipose tissue and fatty liver, but not fat mass, are involved in worsening glycaemic status: The Hiroshima study on glucose metabolism and cardiovascular diseases. Diabetes Obes Metab 2025; 27:3025-3035. [PMID: 40045548 DOI: 10.1111/dom.16307] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/21/2024] [Revised: 02/12/2025] [Accepted: 02/20/2025] [Indexed: 05/04/2025]
Abstract
AIMS Insulin resistance in adipose tissue causes dysregulation of various adipokine levels and ectopic fat accumulation in other organs, such as the liver. This study investigated the effects of insulin resistance in adipose tissue and concomitant fatty liver on each stage of impaired glucose metabolism compared with visceral fat mass. MATERIALS AND METHODS This observational study included 3644 individuals who underwent two 75-g oral glucose tolerance tests at baseline and follow-up. Adipose insulin resistance index (Adipo-IR), lipid accumulation product (LAP) and fatty liver index (FLI) were used as indicators of insulin resistance in the adipose tissue, visceral fat mass and fatty liver, respectively. RESULTS Over a mean 2.9-year follow-up period, 463 (32.4%) individuals progressed from normoglycaemia to prediabetes, and 198 (10.6%) developed type 2 diabetes from prediabetes. Comparing the highest-to-lowest quartiles, baseline levels and changes in Adipo-IR were associated with an increased odds of progression from normoglycaemia to prediabetes (odds ratio [OR], 2.22; 95% CI, 1.36-3.65, OR, 2.70; 95% CI, 1.83-3.98, respectively) and from prediabetes to the onset of type 2 diabetes (OR, 2.02; 95% CI, 1.04-3.92, OR, 3.09; 95% CI, 1.84-4.19, respectively), after adjusting for possible confounders. Changes in FLI were associated with progression from prediabetes to type 2 diabetes. LAP did not affect the progression of impaired glucose metabolism. CONCLUSIONS Adipose tissue insulin resistance, rather than fat mass, is crucial in all stages of deterioration of glycaemic status. Fatty liver plays a decisive role in the eventual development of type 2 diabetes.
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Affiliation(s)
- Nobuo Sasaki
- Health Management and Promotion Center, Hiroshima Atomic Bomb Casualty Council, Hiroshima, Japan
- Department of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
| | - Yoshitaka Ueno
- Health Management and Promotion Center, Hiroshima Atomic Bomb Casualty Council, Hiroshima, Japan
| | - Ryoji Ozono
- Department of General Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan
| | - Yukiko Nakano
- Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan
| | - Yukihito Higashi
- Department of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
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Arslan S, Sahin K, Dal N, Atan RM, Selcuk KT. The relationship between anthropometric indices and cardiovascular risk in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2025; 224:112243. [PMID: 40349849 DOI: 10.1016/j.diabres.2025.112243] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/16/2024] [Revised: 04/07/2025] [Accepted: 05/08/2025] [Indexed: 05/14/2025]
Abstract
OBJECTIVE This study aimed to assess whether novel anthropometric indices-Visceral Adiposity Index (VAI), Conicity Index (CI), and Lipid Accumulation Product (LAP)-could predict Cardiovascular Disease (CVD) risk in individuals with Type 2 Diabetes Mellitus (T2DM). METHODS A methodological study was conducted with 371 hospitalized T2DM patients aged 19-64 at Bandırma Education and Research Hospital. Anthropometric measurements, including waist circumference and Body Mass Index (BMI), were used to calculate VAI, CI, and LAP. The 10-year CVD risk was estimated using the Systematic Coronary Risk Estimation (SCORE) model, and Receiver Operating Characteristic (ROC) curves assessed the predictive performance of the indices. RESULTS The mean SCORE risk was significantly higher in individuals aged ≥ 65 years (p < 0.001), with 70.4 % classified as high-risk. ROC analysis showed that VAI, CI, and LAP had limited discriminatory ability, with Area Under the Curve (AUC) values of 0.454, 0.563, and 0.468, respectively. No significant correlation was found between these indices and the SCORE model in both age groups. CONCLUSION VAI, CI, and LAP do not adequately predict CVD risk in T2DM patients, suggesting that traditional risk assessment methods may remain more reliable for this population.
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Affiliation(s)
- Sedat Arslan
- Department of Nutrition and Dietetics, Bandirma Onyedi Eylul University, Balikesir, Turkey.
| | - Kezban Sahin
- Department of Nutrition and Dietetics, Bandirma Onyedi Eylul University, Balikesir, Turkey.
| | - Nursel Dal
- Department of Nutrition and Dietetics, Bandirma Onyedi Eylul University, Balikesir, Turkey.
| | - Ramazan Mert Atan
- Department of Nutrition and Dietetics, Bandirma Onyedi Eylul University, Balikesir, Turkey.
| | - Kevser Tari Selcuk
- Department of Nutrition and Dietetics, Bandirma Onyedi Eylul University, Balikesir, Turkey.
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Çatak M, Konuk ŞG, Hepsen S. The cholesterol-HDL-glucose (CHG) index and traditional adiposity markers in predicting diabetic retinopathy and nephropathy. J Diabetes Investig 2025. [PMID: 40434226 DOI: 10.1111/jdi.70086] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/19/2025] [Revised: 05/12/2025] [Accepted: 05/16/2025] [Indexed: 05/29/2025] Open
Abstract
OBJECTIVE To investigate the relationship between four metabolic indices-visceral adiposity index (VAI), lipid accumulation product (LAP), triglyceride glucose (TyG) index, and cholesterol-HDL-glucose (CHG) index-and the presence of diabetic nephropathy (DN) and diabetic retinopathy (DR) in patients with long-standing type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS This prospective cross-sectional study included 175 T2DM patients with disease duration >10 years who attended an endocrinology outpatient clinic between July 2021 and January 2022. DR was assessed via fundus photography, and DN was defined using the urinary albumin-to-creatinine ratio and eGFR. VAI, LAP, TyG, and CHG indices were calculated using anthropometric and biochemical parameters. Logistic regression was used to identify independent predictors. RESULTS The mean age was 60 ± 10.1 years; 63.4% were female. DR and DN were observed in 50.3% and 38.9% of patients, respectively. VAI, LAP, and TyG were significantly higher in patients with DN but not with DR. CHG was elevated in both DN and DR (P < 0.05), and was the only independent predictor of DN (P = 0.005). Notably, CHG was significantly higher in proliferative vs non-proliferative DR (P = 0.009), unlike the other indices. CONCLUSIONS While VAI, LAP, and TyG were associated only with nephropathy, CHG was linked to both DN and DR. Its integration of glycemic and lipid parameters may offer greater sensitivity for microvascular risk stratification in T2DM.
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Affiliation(s)
- Merve Çatak
- Faculty of Medicine, Department of Endocrinology and Metabolism, Tokat Gazıosmanpasa University, Tokat, Turkey
| | - Şerife Gülhan Konuk
- Faculty of Medicine, Department of Opthalmology, Tokat Gazıosmanpasa University, Tokat, Turkey
| | - Sema Hepsen
- Department of Endocrinology and Metabolism, Ankara Etlik City Hospital, Ankara, Turkey
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Xian D, Wang W, Li H, Song G, Xu D, Zhang F, Wang Z, Xu W, Meng H, Peng M. Lipid accumulation product: A novel marker for gout and hyperuricemia. PLoS One 2025; 20:e0324139. [PMID: 40392930 PMCID: PMC12091749 DOI: 10.1371/journal.pone.0324139] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/21/2025] [Accepted: 04/21/2025] [Indexed: 05/22/2025] Open
Abstract
BACKGROUND AND AIM Using cross-sectional data from the 2009-2018 National Health and Nutrition Examination Survey, the purpose of this study was to investigate the potential link between lipid accumulation product and gout/hyperuricemia. METHODS The data from 10,871 individuals who participated in the National Health and Nutrition Examination Survey spanning the years 2009-2018 were utilized for additional scrutiny. Participants self-reported gout and hyperuricemia as measured by laboratory test data, and other relevant variables and information for LAP were included. Multivariate logistic regression, restricted cubic spline and p-trend test were employed to determine the association between LAP and gout/hyperuricemia. RESULTS The study included 10,871 adults. The prevalence of hyperuricemia and gout was 20.9% and 5.57%, respectively. Compared with the first quartile, the fourth quartile of lipid accumulation product was associated with a 271% higher risk of hyperuricemia (OR = 3.711, 95% CI 2.732-5.042, p < 0.001) in a fully adjusted model. A similar association was found between continuous increase in lipid accumulation product and hyperuricemia (OR = 2.441, 95%CI = 1.348-4.42, p = 0.005), with p trends showing both < 0.001. The RCS model suggests a significant non-linear relationship between lipid accumulation product and the risk of gout/hyperuricemia. There was an inverted U-shaped relationship between lipid accumulation product and gout/hyperuricemia. CONCLUSIONS This study confirmed that lipid accumulation product has a high potential to predict the risk of gout/hyperuricemia. These findings suggested that the adjustment of the degree of fat accumulation may be a potential way to prevent and control the onset of gout/hyperuricemia.
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Affiliation(s)
- Dexian Xian
- The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China
| | - Wen Wang
- Department of Pediatrics, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
| | - Hui Li
- Department of Acupuncture and Moxibustion, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
| | - Geran Song
- School of Basic Medical Science, Shandong University, Jinan, China
| | - Daozheng Xu
- Department of sleep medicine, Binzhou Traditional Chinese Medicine Hospital, Binzhou, China
| | - Fengjun Zhang
- Department of Pulmonary Diseases, ShuGuang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
| | - Zhe Wang
- College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, China
| | - Wenchang Xu
- College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, China
| | - Hongyan Meng
- Department of Traditional Chinese Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China
| | - Min Peng
- Department of Traditional Chinese Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China
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Zhe J, Cai Y, Bi Y. Association between lipid accumulation product and endometriosis: A cross-sectional study from NHANES 1999-2006. PLoS One 2025; 20:e0323932. [PMID: 40373106 PMCID: PMC12080788 DOI: 10.1371/journal.pone.0323932] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/31/2024] [Accepted: 04/16/2025] [Indexed: 05/17/2025] Open
Abstract
The association of lipid accumulation product (LAP) and the likelihood of endometriosis prevalence has not been previously mentioned. The research aimed to assess the possible potential association between LAP and endometriosis in nationwide research. This cross-sectional analysis was conducted on 2,216 participants selected from the National Health and Nutrition Examination Survey (NHANES) in the 1999-2006 cycles. Logistic regression and stratified analysis by age, race, level of education, BMI, marital status, PIR, glycohemoglobin, drinking, and smoking status were used to analyze the association of the LAP index and odds of endometriosis prevalence. Moreover, smoothed curve fitting was used to evaluate the relevancy of LAP and endometriosis. The multivariate logistic regression model showed a positive association between ln LAP and endometriosis. This trend remained after a full adjustment (odds ratio = 1.37, 95% confidence interval:1.08-1.75, P = 0.010). Compared to the minimum ln LAP quartile, participants in the highest ln LAP had a 93% higher chance of endometriosis incidence (odds ratio = 1.93, 95% confidence interval: 1.08-3.46, P = 0.027). After conducting subgroup analysis and interaction testing, it was found that this positive association was most prominent among women aged 35 years and above and participants with glycohemoglobin≥6%. This nationwide study suggested that an elevated ln LAP was related to an increased endometriosis prevalence. Therefore, LAP may be a valuable tool for predicting the occurrence of endometriosis. Follow-up studies are critical to assess the association between LAP and odds of endometriosis prevalence and explain the potential mechanisms of this relationship.
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Affiliation(s)
- Jing Zhe
- Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Guiyang Maternal and Child Health Care Hospital, Guiyang Children’s Hospital, Guiyang, China
| | - Yanxing Cai
- Department of Clinical Laboratory, Guiyang Maternal and Child Health Care Hospital, Guiyang Children’s Hospital, Guiyang, China
| | - Yakun Bi
- Science and Technology Management Center, Guiyang Maternal and Child Health Care Hospital, Guiyang Children’s Hospital, Guiyang, China
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Zahid MA, Abdelsalam SS, Raïq H, Abunada HH, Parray A, Agouni A. Association of plasma levels of Sestrin2 with adiposity and metabolic function indices in healthy and diabetic subjects from Qatar Biobank. Front Endocrinol (Lausanne) 2025; 16:1518388. [PMID: 40433409 PMCID: PMC12106026 DOI: 10.3389/fendo.2025.1518388] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/28/2024] [Accepted: 02/18/2025] [Indexed: 05/29/2025] Open
Abstract
Background Despite the accumulating evidence from cellular and animal studies, the role of circulating Sestrin2, a stress-inducible antioxidant protein, in human cardiometabolic health remains largely unexplored. Hence, the current study aimed to investigate the association between circulating Sestrin2 and cardiometabolic risk factors in healthy and diabetic individuals. Methods This cross-sectional study leveraging data and plasma samples from the Qatar Biobank investigated the relationship between plasma Sestrin2 levels and various cardiometabolic indices in 326 healthy and 518 diabetic subjects. Results The study found that Sestrin2 levels were significantly lower in diabetic individuals compared to healthy controls (5.49 ng/mL vs 8.25 ng/mL, p < 0.001). In the healthy cohort, higher Sestrin2 levels were associated with a favorable metabolic profile, indicated by lower odd ratios (OR) of high glycated hemoglobin (OR: 0.33), Homeostatic Model Assessment for Insulin Resistance score (OR: 0.58), visceral adiposity index (OR: 0.46), lipid accumulation product (OR: 0.49), atherogenic index of plasma (OR: 0.42) and metabolic syndrome (OR: 0.23). Conversely, in the diabetic cohort, higher Sestrin2 levels were paradoxically linked to increased triglycerides (OR: 1.57), the product of triglyceride glucose and waist circumference (OR: 1.8), body fat (OR: 1.72), waist circumference (OR: 1.82), waist-to-hip ratio (OR: 1.96) and metabolic syndrome (OR: 1.48). Conclusions These findings suggest that Sestrin2 may play a complex and context-dependent role in metabolic regulation, potentially serving as a protective factor in healthy individuals but contributing to metabolic dysfunction in the context of established diabetes. Further research is needed to elucidate the underlying mechanisms and implications for targeted interventions.
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Affiliation(s)
- Muhammad Ammar Zahid
- Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, Qatar
| | - Shahenda Salah Abdelsalam
- Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, Qatar
| | - Hicham Raïq
- Department of Social Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar
| | - Hanan H. Abunada
- Office of Vice President for Medical and Health Sciences, QU Health, Qatar University, Doha, Qatar
| | - Aijaz Parray
- The Neuroscience Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar
| | - Abdelali Agouni
- Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, Qatar
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Cui A, Zhuang Y, Wei X, Han S. The association between lipid accumulation products and bone mineral density in U.S. Adults, a nationally representative cross-sectional study. Sci Rep 2025; 15:16373. [PMID: 40350465 PMCID: PMC12066721 DOI: 10.1038/s41598-025-00833-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/26/2024] [Accepted: 04/30/2025] [Indexed: 05/14/2025] Open
Abstract
LAP (lipid accumulation products) is a new indicator that estimates lipid overaccumulation and central obesity in our bodies. Nevertheless, the relationship of LAP with bone mineral density (BMD) has not been well established. This study aims to assess the association of LAP with BMD in U.S. adults. Multivariate linear regression was employed to detect the relationship of LAP with lumbar BMD in adult Americans. Subgroup and interaction tests were employed to detect the robustness of our findings. Restricted cubic spline (RCS) and threshold effect analysis were used to assess the nonlinear correlation of LAP with lumbar BMD. A total of 3883 participants consisted of 2117 (54.52%) men and 1766 (45.48%) women. The mean age of participants was 39.33 ± 11.53 years. After adjusting all covariates, we found a negative association of ln-LAP with lumbar BMD (β= -0.011, 95% CI: -0.019, -0.004). Threshold effect analysis identified the inflection points of 2.846. The results showed no correlation to the left of the saturation point but a significant negative correlation to the right. Interaction analyses indicated that all subgroups have no effect on this association (P > 0.05). Our study reported a nonlinear negative association of LAP with lumbar BMD. A large LAP may be associated with reduced BMD in American adults. These findings support the clinical utility of LAP as a predictor of osteoporosis and provide valuable insights into developing early intervention strategies for osteoporosis populations.
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Affiliation(s)
- Aiyong Cui
- Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China
| | - Yan Zhuang
- Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China
| | - Xing Wei
- Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China
| | - Shuang Han
- Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China.
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Zhou L, Wang J, Zhou Z, Wang L, Guo Q, Zeng H, Zhong Z, Zhang Y. Long-term dual-trajectories of TyG and LAP and their association with cardiometabolic multimorbidity in midlife: the CARDIA study. Cardiovasc Diabetol 2025; 24:198. [PMID: 40346669 PMCID: PMC12065194 DOI: 10.1186/s12933-025-02761-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/12/2024] [Accepted: 04/26/2025] [Indexed: 05/11/2025] Open
Abstract
BACKGROUND Insulin resistance and central obesity are major risk factors for cardiometabolic diseases. The triglyceride-glucose index (TyG) and lipid accumulation product (LAP) are markers that independently predict cardiometabolic risk. However, their combined long-term trajectories and impact on cardiometabolic multimorbidity (CMM) development remain unclear. METHODS This cohort study utilized data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, which tracked 3467 participants at baseline. Dual-trajectory of TyG and LAP were identified using a group-based dual-trajectory model. Cox proportional hazards models were employed to assess the relationships between dual-trajectory groups and primary cardiometabolic outcomes, including first cardiometabolic disease (FCMD), CMM (two or more conditions such as type 2 diabetes, coronary heart disease, or stroke), and all-cause mortality. Multi-state models were performed to assess the associations of dual-trajectory with CMM development. RESULTS The study included 3467 participants with a mean age of 25.08 years (SD = 3.59). Of these, 43.4% (n = 1505) were male, and 53.2% (n = 1561) were White. Three distinct dual-trajectory groups were identified: low-increasing (61.5%), high-amplitude fluctuation (7.6%), and high-increasing (30.9%). After multivariate adjustment, compared with the low-increasing group, the high-amplitude fluctuation group exhibited significantly higher risks for FCMD (hazard ratio [HR] 1.38, 95% confidence interval [CI]: 1.08-1.77), CMM (HR 2.63, 95% CI 1.21-5.71), and all-cause mortality (HR 2.16, 95% CI 1.30-3.56), as well as elevated risks for transitions from baseline to FCMD (HR 1.41, 95% CI 1.17-1.63), FCMD to CMM (HR 2.07, 95% CI 1.53-3.96), CMM to death (HR 2.87, 95% CI 1.19-7.62). The high-increasing group showed similar results. CONCLUSIONS Elevated and fluctuating trajectories of TyG and LAP from early adulthood are associated with increased risks of CMM development in midlife.
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Affiliation(s)
- Lingqu Zhou
- Department of Ultrasonography and Electrocardiograms, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat‑sen University Cancer Center, Guangzhou, 510060, People's Republic of China
| | - Junjie Wang
- Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, People's Republic of China
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, Guangdong, People's Republic of China
| | - Zirui Zhou
- Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yanjiang Road, Guangzhou, 510120, People's Republic of China
| | - Liangjiao Wang
- Department of Ultrasonography and Electrocardiograms, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat‑sen University Cancer Center, Guangzhou, 510060, People's Republic of China
| | - Qi Guo
- Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yanjiang Road, Guangzhou, 510120, People's Republic of China
| | - Hui Zeng
- Department of Ultrasonography and Electrocardiograms, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat‑sen University Cancer Center, Guangzhou, 510060, People's Republic of China
| | - Ziyue Zhong
- Department of Ultrasonography and Electrocardiograms, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat‑sen University Cancer Center, Guangzhou, 510060, People's Republic of China
| | - Yinyin Zhang
- Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yanjiang Road, Guangzhou, 510120, People's Republic of China.
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Tayhan F, Helvacı G, Yabancı Ayhan N. Obesity Parameters in Women Is Associated With AMY1 Gene Copy Number, Nesfatin-1 Level, and Dietary Intake: A Case-Control Study. Mol Nutr Food Res 2025; 69:e70049. [PMID: 40190144 PMCID: PMC12087705 DOI: 10.1002/mnfr.70049] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/13/2024] [Revised: 03/11/2025] [Accepted: 03/12/2025] [Indexed: 05/20/2025]
Abstract
AMY1 gene copy number (GCN) variations and the satiety hormone Nesfatin-1 have recently emerged as potential contributors to obesity and related metabolic disturbances. This study evaluated the relationship between AMY1 GCN, Nesfatin-1 level, and nutritional status in obese/overweight and normal-weight women. Participants included 40 normal-weight and 45 overweight/obese women aged 19-50. Data were collected through a demographic and dietary habits questionnaire, a 3-day food recall, anthropometric measurements, and body composition analysis via bioelectrical impedance. Saliva samples were used to measure AMY1 GCN and Nesfatin-1 levels. The AMY1 GCN was significantly lower in overweight/obese participants compared to normal-weight participants. Increased AMY1 GCN was associated with a decrease in BMI (-0.154 units), while increased Nesfatin-1 level was linked to a rise in BMI (0.196 units) (p < 0.05). Women with low AMY1 GCN had higher daily intakes of energy, carbohydrate, protein, and fat (p < 0.05). This study highlights the significant roles of AMY1 GCN and Nesfatin-1 in the development of obesity. The findings suggest that lower AMY1 GCN and higher Nesfatin-1 levels are associated with unfavorable nutritional and metabolic profiles. Further comprehensive studies on genetic and hormonal factors, including AMY1 GCN and Nesfatin-1, are recommended to guide obesity prevention and treatment strategies.
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Affiliation(s)
- Fatma Tayhan
- Health Sciences FacultyDepartment of Nutrition and DieteticsÇankırı Karatekin UniversityÇankırıTurkey
| | - Gizem Helvacı
- Health Sciences FacultyDepartment of Nutrition and DieteticsMehmet Akif Ersoy UniversityBurdurTurkey
| | - Nurcan Yabancı Ayhan
- Health Sciences FacultyDepartment of Nutrition and DieteticsAnkara UniversityAnkaraTurkey
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12
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Kong X, Wang Q, Wang H, Yang Y, Guo L, Song S, Zhao Y, Ma X, Wang X, Sun Q. Association of lipid accumulation products, or cardiometabolic index with asymptomatic intracranial arterial stenosis: A population-based study in Shandong, China. J Stroke Cerebrovasc Dis 2025; 34:108273. [PMID: 40044095 DOI: 10.1016/j.jstrokecerebrovasdis.2025.108273] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/09/2024] [Revised: 02/11/2025] [Accepted: 03/02/2025] [Indexed: 03/30/2025] Open
Abstract
OBJECTIVES This study aimed to investigate the association of novel obesity indicators (lipid accumulation product [LAP] and cardiometabolic index [CMI]) with asymptomatic intracranial arterial stenosis (aICAS), particularly in different obesity statuses. MATERIALS AND METHODS The study included 1994 participants (aged ≥ 40 years) from the Rose Asymptomatic Intracranial Artery Stenosis (RICAS) study, free of stroke or transient ischemic attack. Participants with aICAS were screened using transcranial Doppler ultrasound and diagnosed via magnetic resonance angiography. Multivariate logistic regression and receiver operating characteristic (ROC) curves were used to explore the association of LAP or CMI with aICAS. RESULTS A total of 146 participants were diagnosed with aICAS. Higher levels of LAP and CMI were associated with aICAS, particularly with moderate-to-severe aICAS. Notably, LAP was significantly associated with aICAS (OR 1.58; 95 % CI, 1.00-2.49; P = 0.048), and was showed the highest area under the curve (AUC, 0.654) among the three indicators (LAP, CMI, and BMI) in underweight and normal weight participants (Body mass index [BMI] ≤23.9 kg/m²). In the obesity population (BMI ≥28.0 kg/m2), CMI was significantly associated with aICAS (OR 1.40; 95 % CI, 1.11-1.77; P = 0.005), and was showed the highest AUC (0.610). CONCLUSIONS This study found a positive association between elevated levels of LAP or CMI and aICAS. Furthermore, LAP was significantly correlated with aICAS in underweight and normal weight individuals, while CMI was associated with aICAS in obesity individuals. Our findings may provide additional risk stratification information for aICAS.
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Affiliation(s)
- Xianglong Kong
- Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
| | - Qiao Wang
- Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
| | - Hailing Wang
- Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
| | - Yumeng Yang
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
| | - Liying Guo
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
| | - Shiqing Song
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
| | - Yuanyuan Zhao
- Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
| | - Xiaotong Ma
- Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
| | - Xiang Wang
- Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
| | - Qinjian Sun
- Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
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13
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Facio F, Colonnello E, Alzweri L, Citrin E, Dubinskaya A, Falsetta M, Fregonesi A, Kellogg-Spadt S, Lopes LS, Jannini EA. Infection, inflammation, and sexual function in male and female patients-recommendations from the Fifth International Consultation on Sexual Medicine (ICSM 2024). Sex Med Rev 2025:qeaf021. [PMID: 40302466 DOI: 10.1093/sxmrev/qeaf021] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/17/2024] [Revised: 03/08/2025] [Accepted: 03/15/2025] [Indexed: 05/02/2025]
Abstract
INTRODUCTION Sexual dysfunction in men and women is an important clinical issue; infection and inflammation can cause social, medical, and psychological problems that have a profound impact on sexual and reproductive health worldwide. OBJECTIVES We set out to identify sexual dysfunctions in men and women that arise from infection and inflammation and propose meaningful interventions, as evaluated by the Fifth International Consultation on Sexual Medicine (ICSM) held in June 2024 in Madrid (Spain). METHODS We searched MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) for published peer-reviewed journal articles and ClinicalTrials.gov and the World Health Organization's (WHO's) International Clinical Trials Registry Platform for prospective trials. This manuscript represents the opinions of 10 experts from 6 countries developed in a consensus process after completing the literature review, which produced a list of recommendations graded as weak or strong. This document was presented for peer review and debate in a public forum, and revisions were made based on the recommendations of chairpersons of the 5th ICSM. RESULTS Infections, and in particular sexually transmitted infections (STIs), dramatically affect the sexual and reproductive health of individuals and couples, irrespective of sexual orientation and gender. Similarly, non-communicable chronic diseases (NCDs), through the common pathogenetic mechanism of inflammation, can directly impair the ability to copulate, reproduce, and enjoy sexual life. CONCLUSIONS This expert consensus recommends prioritizing early detection, comprehensive treatment approaches, and preventive measures to mitigate the effects of infection and inflammation on sexual health, both for the patient and the couple. These insights provide a foundation for improving patient outcomes and fostering global awareness of the interconnections between infection, inflammation, and sexual dysfunction.
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Affiliation(s)
- Fernando Facio
- Men's Health Division University Hospital - FUNFARME, Brazil
| | - Elena Colonnello
- Chair of Endocrinology and Medical Sexology (ENDOSEX), University of Tor Vergata, Rome, Italy
| | - Laith Alzweri
- Division of Urology, Department of Surgery, University of Texas Medical Branch, Galveston, TX, United States
| | - Estela Citrin
- Fellow of the European Committee of Sexual Medicine (FECSM)
| | - Alexandra Dubinskaya
- Los Angeles Institute for Pelvic and Sexual Health, Beverly Hills, United States
- Cedars-Sinai Medical Center, Los Angeles, CA
| | - Megan Falsetta
- University of Rochester Medical Center, Rochester, NY, United States
| | | | | | | | - Emmanuele A Jannini
- Chair of Endocrinology and Medical Sexology (ENDOSEX), University of Tor Vergata, Rome, Italy
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14
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Abenavoli L, Scarlata GGM, Borelli M, Suraci E, Marasco R, Imeneo M, Spagnuolo R, Luzza F. Use of Metabolic Scores and Lipid Ratios to Predict Metabolic Dysfunction-Associated Steatotic Liver Disease Onset in Patients with Inflammatory Bowel Diseases. J Clin Med 2025; 14:2973. [PMID: 40364004 PMCID: PMC12072931 DOI: 10.3390/jcm14092973] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/25/2025] [Revised: 04/23/2025] [Accepted: 04/24/2025] [Indexed: 05/15/2025] Open
Abstract
Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized in inflammatory bowel disease (IBD) patients due to chronic inflammation and metabolic disturbances. However, reliable non-invasive biomarkers for MASLD prediction in this population are lacking. This study evaluated the predictive value of metabolic scores and lipid ratios for MASLD onset in IBD patients. Methods: An observational retrospective study was conducted on 358 IBD patients at the "Renato Dulbecco" Teaching Hospital in Catanzaro, Italy, in a period between 1 January 2021 and 31 December 2024. Clinical and laboratory data, including metabolic scores and lipid ratios, were analyzed using the chi-square and Kruskal-Wallis tests as appropriate. Post hoc comparisons were conducted using Dunn's test. Receiver operating characteristic analysis assessed their predictive accuracy for MASLD. p < 0.05 was considered significant. Results: IBD-MASLD patients had a significantly higher body mass index (BMI, 27 ± 4 vs. 22 ± 2 kg/m2; p < 0.001), waist circumference (100 ± 11 vs. 85 ± 4 cm; p < 0.001), other anthropometric parameters, metabolic scores, and lipid ratios than IBD-only patients. The metabolic score for insulin resistance [METS-IR, area under curve (AUC = 0.754)] and waist circumference (AUC = 0.754) exhibited the highest predictive accuracy, followed by the lipid accumulation product (LAP, AUC = 0.737), BMI (AUC = 0.709), and triglyceride/high-density lipoprotein (TG/HDL, AUC = 0.701). Insulin resistance scores, including the homeostasis model assessment of insulin resistance (AUC = 0.680) and triglyceride-glucose index (AUC = 0.674), were of moderate predictive use. The visceral adiposity index (AUC = 0.664) and low-density lipoprotein/high-density lipoprotein (AUC = 0.656) showed lower discriminative ability, while the fibrosis-4 index (AUC = 0.562) had the weakest diagnostic performance. Conclusions: Our findings suggest that MASLD in IBD is primarily driven by cardiometabolic dysfunction. The introduction of the METS-IR, LAP, and TG/HDL into clinical assessments of IBD patients could prove useful in preventing liver and cardiovascular complications in this setting.
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Affiliation(s)
- Ludovico Abenavoli
- Department of Health Sciences, University “Magna Graecia”, 88100 Catanzaro, Italy; (G.G.M.S.); (R.S.); (F.L.)
| | | | - Massimo Borelli
- UMG School of PhD Programmes “Life Sciences and Technologies”, University “Magna Graecia”, 88100 Catanzaro, Italy;
| | - Evelina Suraci
- Inflammatory Bowel Disease Unit, Renato Dulbecco University Hospital, 88100 Catanzaro, Italy; (E.S.); (R.M.); (M.I.)
| | - Raffaella Marasco
- Inflammatory Bowel Disease Unit, Renato Dulbecco University Hospital, 88100 Catanzaro, Italy; (E.S.); (R.M.); (M.I.)
| | - Maria Imeneo
- Inflammatory Bowel Disease Unit, Renato Dulbecco University Hospital, 88100 Catanzaro, Italy; (E.S.); (R.M.); (M.I.)
| | - Rocco Spagnuolo
- Department of Health Sciences, University “Magna Graecia”, 88100 Catanzaro, Italy; (G.G.M.S.); (R.S.); (F.L.)
| | - Francesco Luzza
- Department of Health Sciences, University “Magna Graecia”, 88100 Catanzaro, Italy; (G.G.M.S.); (R.S.); (F.L.)
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15
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Clayton-Chubb D, Commins I, Roberts SK, Majeed A, Woods RL, Ryan J, Schneider HG, Lubel JS, Hodge AD, McNeil JJ, Kemp WW. Scores to predict steatotic liver disease - correlates and outcomes in older adults. NPJ GUT AND LIVER 2025; 2:9. [PMID: 40260419 PMCID: PMC12009214 DOI: 10.1038/s44355-025-00021-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 12/12/2024] [Accepted: 03/19/2025] [Indexed: 04/23/2025]
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a significant cause of chronic liver disease globally, and the rising prevalence of MASLD is occurring in parallel with the global aging population. The use of non-invasive biomarker tools to rule-in or rule-out hepatic steatosis is important in large epidemiological studies in this field. While the Fatty Liver Index (FLI) is the best validated tool in older adults, not all studies will have the necessary parameters for steatosis identification. This retrospective post-hoc analysis of the ASPirin in Reducing Events in the Elderly (ASPREE) study involved 16,703 Australian adults aged ≥70 years. Using the FLI as the 'gold standard' index, we evaluated the correlation with other indices: the Dallas Steatosis Index (DSI), Framingham Steatosis Index, ZJU index (ZJU), Hepatic Steatosis Index (HSI), Lipid Accumulation Product (LAP), and Visceral Adiposity Index (VAI), as well as age- and sex-adjusted outcome measures including mortality, major adverse cardiovascular events (MACE), atrial fibrillation (AF), and persistent physical disability. Of the non-FLI indices, the DSI and FSI had the highest percentage of participants correctly classified as having MASLD (97.7% and 93.8% respectively). The FSI, LAP, and VAI were associated with MACE. The FSI and FLI were predictive of incident AF. The FLI, DSI, FSI, LAP and VAI were associated with physical disability. No MASLD score was associated with increased mortality. Indeed, MASLD defined by the ZJU and HSI were both inversely associated with mortality. As such, we've demonstrated that the FSI and DSI are the most accurate scores for identifying MASLD in older adults when compared to the FLI as the gold standard. The FSI is associated with MACE, AF, and persistent physical disability, lending support to its use in identifying older persons with MASLD when the FLI is unable to be calculated.
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Affiliation(s)
- Daniel Clayton-Chubb
- Department of Gastroenterology, Alfred Health, Melbourne, VIC Australia
- School of Translational Medicine, Monash University, Melbourne, VIC Australia
- Department of Gastroenterology, Eastern Health, Melbourne, VIC Australia
- Department of Gastroenterology, St Vincent’s Hospital, Melbourne, VIC Australia
| | - Isabella Commins
- Department of Gastroenterology, Alfred Health, Melbourne, VIC Australia
- Department of Gastroenterology, St Vincent’s Hospital, Melbourne, VIC Australia
| | - Stuart K. Roberts
- Department of Gastroenterology, Alfred Health, Melbourne, VIC Australia
- School of Translational Medicine, Monash University, Melbourne, VIC Australia
| | - Ammar Majeed
- Department of Gastroenterology, Alfred Health, Melbourne, VIC Australia
- School of Translational Medicine, Monash University, Melbourne, VIC Australia
| | - Robyn L. Woods
- School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC Australia
| | - Joanne Ryan
- School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC Australia
| | - Hans G. Schneider
- School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC Australia
- Department of Pathology, Alfred Health, Melbourne, VIC Australia
| | - John S. Lubel
- Department of Gastroenterology, Alfred Health, Melbourne, VIC Australia
- School of Translational Medicine, Monash University, Melbourne, VIC Australia
- Department of Gastroenterology, Northern Health, Melbourne, VIC Australia
| | - Alexander D. Hodge
- Department of Gastroenterology, Eastern Health, Melbourne, VIC Australia
- School of Health and Biomedical Science, RMIT University, Melbourne, VIC Australia
- Department of Medicine, Eastern Clinical School, Monash University, Melbourne, VIC Australia
| | - John J. McNeil
- School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC Australia
| | - William W. Kemp
- Department of Gastroenterology, Alfred Health, Melbourne, VIC Australia
- School of Translational Medicine, Monash University, Melbourne, VIC Australia
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16
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Woodiwiss AJ, Norton GR, Libhaber CD, Sareli P, Dessein PHC. Differential Association Between Ten Indices of Insulin Resistance and End-Organ Damage in a Community of African Ancestry in Africa. J Clin Med 2025; 14:2703. [PMID: 40283533 PMCID: PMC12027772 DOI: 10.3390/jcm14082703] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/11/2025] [Revised: 04/07/2025] [Accepted: 04/11/2025] [Indexed: 04/29/2025] Open
Abstract
Objective: Various insulin resistance (IR) indices have been developed to assess cardiovascular (CVS) risk. We compared the association between ten IR indices and cardiac, renal, and vascular end-organ measures in a predominantly young (age 45.0 ± 18.3 years) South African Black population. Methods: We assessed the relationships between ten IR indices (homeostatic model assessment for IR [HOMA-IR], quantitative insulin sensitivity check index [QUICKI], metabolic score for IR [METS-IR], triglyceride-glucose index [TyG], TyG-body mass index [TyG-BMI], TyG-waist circumference [TyG-WC], TyG-waist-to-height ratio [TyG-WHtR], triglyceride to high-density cholesterol concentration [TyG-HDL], lipid accumulation product [LAP], visceral adiposity index [VAI]) and end-organ measures in 779 community participants of African ancestry. Results: HOMA-IR and QUICKI were the only IR indices consistently associated with end-organ measures (left ventricular [LV] mass index, p ≤ 0.005; LV relative wall thickness, p < 0.0001; early-to-late mitral velocity, p ≤ 0.01; E/e', p ≤ 0.002; e', p < 0.0001; pulse wave velocity, p = 0.036 (HOMA-IR only); glomerular filtration rate [GFR], p < 0.0001), independent of confounders. Furthermore, HOMA-IR was consistently higher, and QUICKI lower, in those with compared to those without end-organ damage (LV hypertrophy [p ≤ 0.03], concentric LV [p < 0.03], and reduced GFR [p ≤ 0.008]), independent of confounders. Importantly, the associations between HOMA-IR or QUICKI and end-organ measures were independent of additional CVS risk factors, including adiposity measures, and were replicated in the participants without diabetes mellitus (n = 669) and in the participants without high blood pressure (n = 505). Conclusions: In a predominantly young community of African ancestry, of ten recommended IR indices, only HOMA-IR and QUICKI were consistently associated with end-organ damage independent of CVS risk factors.
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Affiliation(s)
- Angela J. Woodiwiss
- Cardiovascular Pathophysiology and Genomics Research Unit, Department of Physiology, School of Biomedical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa (P.H.C.D.)
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17
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Tarantino G, Imbimbo C, Ferro M, Bianchi R, La Rocca R, Lucarelli G, Lasorsa F, Busetto GM, Finati M, Pastore AL, Al Salhi Y, Fuschi A, Terracciano D, Giampaglia G, Falabella R, Barone B, Fusco F, Del Giudice F, Crocetto F. Which Surrogate Marker of Insulin Resistance Among Those Proposed in the Literature Better Predicts the Presence of Non-Metastatic Bladder Cancer? J Clin Med 2025; 14:2636. [PMID: 40283465 PMCID: PMC12027915 DOI: 10.3390/jcm14082636] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/06/2025] [Revised: 03/25/2025] [Accepted: 04/09/2025] [Indexed: 04/29/2025] Open
Abstract
Background: Recent evidence has shown that insulin resistance (IR), a hallmark of nonalcoholic fatty liver disease, predicts bladder cancer (BC) presence. However, the best surrogate marker of IR in predicting BC is still unclear. This study examined the relationships among ten surrogate markers of IR and the presence of BC. Methods: Data from 209 patients admitted to two urology departments from September 2021 to October 2024 were retrospectively analyzed. Individuals (median age 70 years) were divided into two groups (123 and 86 patients, respectively) based on the presence/absence after cystoscopy/TURB of non-metastatic BC. Univariate logistic regression was used to determine the relationships between groups, and the following IR parameters: Triglyceride-Glucose (TyG) index, TyG-BMI, HOMA-IR HOMAB, MetS-IR, Single Point Insulin Sensitivity Estimator, Disposition Index, non-HDL/HDL, TG/HDL-C ratio and Lipoprotein Combine Index. Stepwise logistic regressions were carried out to evaluate the significant predictions and LASSO regression to confirm any significant variable(s). The predictive value of the index test for coexistent BC was evaluated using receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC). Results: The univariate analysis revealed that the TyG index and MetS-IR were associated with the BC presence. Specifically, the associations of the TyG index and MetS-IR were more significant in participants =/> 65 years old. In multivariate analysis, the stepwise logistic regression, evaluating the most representative variables at univariate analysis, revealed a prediction of BC by only TyG index (OR 2.51, p = 0.012), confirmed by LASSO regression, with an OR of 3.13, p = 0.004). Assessing the diagnostic reliability of TyG, it showed an interesting predictive value for the existence of BC (AUC = 0.60; 95% CI, 0.51-0.68, cut-off 8.50). Additionally, a restricted cubic spline model to fit the dose-response relationship between the values of the index text (TyG) and the BC evidenced the presence of a non-linear association, with a high predictive value of the first knot, corresponding to its 10th percentile. The decision curve analysis confirmed that the model (TyG) has utility in supporting clinical decisions. Conclusions: Compared to other surrogate markers of IR, the TyG index is effective in identifying individuals at risk for BC. A TyG threshold of 8.5 was highly sensitive for detecting BC subjects and may be suitable as an auxiliary diagnostic criterion for BC in adults, mainly if less than 65 years old.
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Affiliation(s)
- Giovanni Tarantino
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”, 80131 Naples, Italy
| | - Ciro Imbimbo
- Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy; (C.I.); (R.L.R.); (G.G.); (F.C.)
| | - Matteo Ferro
- Unit of Urology, Department of Health Science, University of Milan, ASST Santi Paolo e Carlo, 20172 Milan, Italy; (M.F.); (R.B.)
| | - Roberto Bianchi
- Unit of Urology, Department of Health Science, University of Milan, ASST Santi Paolo e Carlo, 20172 Milan, Italy; (M.F.); (R.B.)
| | - Roberto La Rocca
- Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy; (C.I.); (R.L.R.); (G.G.); (F.C.)
| | - Giuseppe Lucarelli
- Urology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy (F.L.)
| | - Francesco Lasorsa
- Urology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy (F.L.)
| | - Gian Maria Busetto
- Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy; (G.M.B.); (M.F.)
| | - Marco Finati
- Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy; (G.M.B.); (M.F.)
| | - Antonio Luigi Pastore
- Department of Urology, Sapienza University of Rome, 04100 Latina, Italy; (A.L.P.); (Y.A.S.); (A.F.)
| | - Yazan Al Salhi
- Department of Urology, Sapienza University of Rome, 04100 Latina, Italy; (A.L.P.); (Y.A.S.); (A.F.)
| | - Andrea Fuschi
- Department of Urology, Sapienza University of Rome, 04100 Latina, Italy; (A.L.P.); (Y.A.S.); (A.F.)
| | - Daniela Terracciano
- Department of Translational Medical Sciences, University of Naples “Federico II”, 80131 Naples, Italy;
| | - Gaetano Giampaglia
- Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy; (C.I.); (R.L.R.); (G.G.); (F.C.)
| | | | - Biagio Barone
- Department of Urology, Ospedale San Paolo, ASL NA1 Centro, 80147 Naples, Italy;
| | - Ferdinando Fusco
- Division of Urology, Department of Surgical Sciences, AORN Sant’Anna e San Sebastiano, 81100 Caserta, Italy;
| | | | - Felice Crocetto
- Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy; (C.I.); (R.L.R.); (G.G.); (F.C.)
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18
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Liu H, Ye H, Zhang X, Wen Y, Wang J, Yu M, Yang X, Ma C, Wu L, Zhao Y, Wang L. The association between body roundness index and mortality in diabetes. BMC Cardiovasc Disord 2025; 25:273. [PMID: 40205327 PMCID: PMC11983762 DOI: 10.1186/s12872-025-04689-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/19/2024] [Accepted: 03/19/2025] [Indexed: 04/11/2025] Open
Abstract
BACKGROUND The association between body roundness index (BRI) and all-cause mortality and the occurrence of cardiovascular disease (CVD) in patients with diabetes is unknown. This study aimed to determine the association between BRI and all-cause/CVD mortality in a diabetic cohort. METHODS A total of 8227 individuals with diabetes from the 1999-2018 National Health and Nutrition Examination Survey (NHANES) database were included. Multifactorial Cox regression models were used to analyze the association between BRI and mortality in patients with diabetes. Multivariate-adjusted restricted cubic spline (RCS) regression was used to test for nonlinearity. RESULTS During a median follow-up of 7.25 years, a total of 27.22% died, with 9.18% of these deaths due to CVD. After fully adjusting for potential confounders, BRI remained significantly associated with all-cause/CVD mortality in the diabetic population. The restricted cubic splines revealed no significant nonlinear relationship between BRI and all-cause mortality (P = 0.29) or CVD mortality (P = 0.73). BRI was better associated with all-cause/CVD mortality in patients with diabetes compared to other body metabolic indices. CONCLUSIONS In patients with diabetes, we found an association between BRI and all-cause/CVD mortality.
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Affiliation(s)
- Han Liu
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China
- The Academician Cooperative Laboratory of Basic and Translational Research on Chronic Diseases, Guangzhou, 510630, China
| | - Haowen Ye
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China
- The Academician Cooperative Laboratory of Basic and Translational Research on Chronic Diseases, Guangzhou, 510630, China
| | - Xiaofang Zhang
- The Academician Cooperative Laboratory of Basic and Translational Research on Chronic Diseases, Guangzhou, 510630, China
- The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Guangzhou, 510630, China
| | - Yun Wen
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China
- The Academician Cooperative Laboratory of Basic and Translational Research on Chronic Diseases, Guangzhou, 510630, China
| | - Jiaxin Wang
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China
- The Academician Cooperative Laboratory of Basic and Translational Research on Chronic Diseases, Guangzhou, 510630, China
| | - Meixin Yu
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China
- The Academician Cooperative Laboratory of Basic and Translational Research on Chronic Diseases, Guangzhou, 510630, China
| | - Xian Yang
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China
- The Academician Cooperative Laboratory of Basic and Translational Research on Chronic Diseases, Guangzhou, 510630, China
| | - Caixia Ma
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China
- The Academician Cooperative Laboratory of Basic and Translational Research on Chronic Diseases, Guangzhou, 510630, China
| | - Liangyan Wu
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China
| | - Yongting Zhao
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China
| | - Lihong Wang
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
- The Academician Cooperative Laboratory of Basic and Translational Research on Chronic Diseases, Guangzhou, 510630, China.
- The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Guangzhou, 510630, China.
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19
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Torun C, Ankaralı H. A Comparative Evaluation of Adiposity Indices for Predicting Visceral Adipose Tissue Magnitude: Insights from NHANES 2011-2018. Metab Syndr Relat Disord 2025. [PMID: 40195950 DOI: 10.1089/met.2025.0005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/09/2025] Open
Abstract
Background and Aims: Visceral adipose tissue (VAT) is a key cardiometabolic risk factor. This study evaluates the association between VAT and adiposity indices and identifies reliable predictors of increased VAT. Methods: This cross-sectional study utilized data from 4696 participants in the National Health and Nutrition Examination Survey 2011-2018. VAT was measured via dual-energy X-ray absorptiometry. Adiposity indices included body mass index (BMI), waist circumference (WC), lipid accumulation product, visceral adiposity index, body shape index, body roundness index, and metabolic score for visceral fat (METS-VF). Correlation analysis, receiver operating characteristic curve analysis, and multivariate adaptive regression splines (MARS) modeling evaluated the performance of indices and identified key predictors of VAT. Results: All adiposity indices were significantly correlated with VAT (P < 0.001). Among them, METS-VF demonstrated the highest predictive performance for increased VAT (>130 cm2) followed by WC. Optimal cutoff values for METS-VF were 7.1 [areas under the curve (AUC): 0.887, 95% confidence interval (CI): 0.873-0.899] in men and 7.5 (AUC: 0.904, 95% CI: 0.891-0.916) in women. For WC, the cutoff values were 99.5 cm (AUC: 0.866, 95% CI: 0.851-0.879) in men and 96 cm (AUC: 0.883, 95% CI: 0.869-0.896) in women. MARS modeling identified race, age, WC, BMI, glucose, high-density lipoprotein cholesterol, and triglycerides as significant predictors of VAT, achieving an R2 of 75.2%. Conclusion: METS-VF demonstrated the highest predictive value among the indices evaluated for predicting increased VAT. It may serve as a valuable tool in assessing visceral obesity and associated cardiometabolic risks.
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Affiliation(s)
- Cundullah Torun
- Department of Internal Medicine, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Kadikoy/Istanbul, Türkiye
| | - Handan Ankaralı
- Department of Biostatistics and Medical Informatics, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Kadikoy/Istanbul, Türkiye
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20
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Pokharel DR, Maskey A, Kathayat G, Manandhar B, Kafle R, Das Manandhar K. Evaluation of novel and traditional anthropometric indices for predicting metabolic syndrome and its components: a cross-sectional study of the Nepali adult population. Sci Rep 2025; 15:12065. [PMID: 40199938 PMCID: PMC11978977 DOI: 10.1038/s41598-025-86489-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/17/2024] [Accepted: 01/10/2025] [Indexed: 04/10/2025] Open
Abstract
BACKGROUND Various anthropometric indices have been proposed to assess central obesity and predict metabolic syndrome (MetS). However, their ability to predict MetS has not been evaluated in the Nepali adult population. This study compared the predictive potential of 12 novel and traditional anthropometric indices for MetS and its components among Nepali adults. METHODS This cross-sectional study, conducted between January 2022 and June 2023, involved 1,116 adult participants (424 females, 692 males) aged 30-86 years from Gandaki Province, Nepal. Twelve anthropometric indices were calculated from the primary anthropometric and metabolic parameters. MetS was defined according to the modified NCEP-ATP III criteria. Logistic regression models were used to assess the strength of associations between these indices and MetS. Receiver operating characteristic (ROC) curve analysis was used to determine the predictive potential of these indices for MetS and its components. AUC differences between various index pairs were also calculated. RESULTS The overall prevalence of MetS in our study participants was 52.7%. The VAI demonstrated the best performance in predicting MetS (AUC: 0.865 for females, 0.882 for males), followed by LAP (AUC: 0.848 for females, 0.866 for males). The WHR showed good performance (AUC: 0.749 for females, 0.722 for males). BMI, the well-known traditional measure of body adiposity, demonstrated lower predictive ability (AUC: 0.586 for females, 0.571 for males). The optimal cutoffs were as follows: VAI > 2.37 for females, > 1.71 for males; LAP > 37.21 for females, > 47.74 for males; WHR > 0.97 for females, > 0.98 for males; and BMI > 23.10 for females, > 23.90 for males. BAI exhibited the poorest diagnostic performance for MetS prediction in both sexes (AUC < 0.555). Both the VAI and LAP were strongly positively associated (p < 0.001) with increased odds of MetS in both females (OR: 16.03, 95% CI: 9.77-26.31) and males (OR: 24.88, 95% CI: 16.51-37.48). CONCLUSION Among Nepali adults, the VAI and LAP outperform traditional anthropometric indices in predicting MetS and its components, suggesting their potential as effective screening tools for early detection. These findings contribute to the development of population-specific screening strategies for MetS in resource-limited settings such as Nepal, potentially enhancing early detection and prevention of cardiometabolic disorders.
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Affiliation(s)
- Daya Ram Pokharel
- Department of Biochemistry, Manipal College of Medical Sciences, Pokhara-16, Kaski, Nepal.
| | - Abhishek Maskey
- Department of Internal Medicine, Manipal Teaching Hospital, Pokhara-11, Kaski, Nepal
| | - Goma Kathayat
- Department of Biochemistry, Manipal College of Medical Sciences, Pokhara-16, Kaski, Nepal
| | - Binod Manandhar
- Department of Mathematical Sciences, Clark Atlanta University, Atlanta, GA, USA
| | - Ramchandra Kafle
- Department of Internal Medicine, Manipal Teaching Hospital, Pokhara-11, Kaski, Nepal
| | - Krishna Das Manandhar
- Central Department of Biotechnology, Tribhuvan University, Kirtipur, Kathmandu, Nepal
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21
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Zhang L, Liang C, Yan Z, Li Q. Association between cardiac metabolic index and diabetic kidney disease: a cross-sectional study of NHANES 1999-2018. JOURNAL OF HEALTH, POPULATION, AND NUTRITION 2025; 44:105. [PMID: 40181374 PMCID: PMC11969728 DOI: 10.1186/s41043-025-00826-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 01/05/2025] [Accepted: 03/11/2025] [Indexed: 04/05/2025]
Abstract
BACKGROUND The Cardiac Metabolic Index (CMI) is a comprehensive metabolic indicator, but studies on its relationship with Diabetic Kidney Disease (DKD) are limited. We aim to explore the association between CMI and DKD. METHODS We obtained participant-related data from the National Health and Nutrition Examination Survey (NHANES), including complete information on DKD, CMI, and other covariates. We employed weighted multivariable logistic regression models, restricted cubic spline (RCS) regression analysis, subgroup analyses, and interaction tests to explore the relationship between CMI and DKD. Additionally, we utilized receiver operating characteristic (ROC) curves to compare the performance of CMI in identifying DKD relative to a body shape index (ABSI), body roundness index (BRI), visceral adiposity index (VAI), and lipid accumulation product (LAP) indices. RESULTS According to the logistic regression analysis, a positive correlation between CMI and DKD was observed among the 2371 participants included in the study (OR: 1.40, 95% CI: 1.19-1.66). RCS analysis indicated that this relationship is nonlinear. When CMI was converted from a continuous variable to quartiles, the prevalence of DKD in the highest quartile group showed a significant 84% increase compared to the lowest quartile group (OR: 1.84, 95% CI: 1.24-2.72). The area under the ROC curve of CMI for identifying DKD was 0.67, outperforming other indices. The results of subgroup analyses and interaction tests were stable. CONCLUSION Elevated CMI is associated with an increased risk of DKD and can serve as a low-cost screening tool, allowing physicians to potentially identify high-risk diabetic patients early and implement timely interventions to slow the progression of DKD.
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Affiliation(s)
- Lu Zhang
- School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China
| | - Cuiying Liang
- Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
| | - Zhaoqi Yan
- Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
| | - Qingzhen Li
- Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
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22
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Ma N, Cui XN, Wang N. The predictive value of triglyceride-glucose index, lipid accumulation product and lipid ratio on metabolic syndrome in polycystic ovary syndrome patients. J Obstet Gynaecol Res 2025; 51:e16283. [PMID: 40189225 DOI: 10.1111/jog.16283] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/30/2024] [Accepted: 03/22/2025] [Indexed: 05/17/2025]
Abstract
OBJECTIVES To identify reliable indicators to predict the occurrence of metabolic syndrome (MetS) and to provide an effective way to prevent it in polycystic ovary syndrome (PCOS), we explored the relationships between triglyceride-glucose index (Ty-G), lipid accumulation product (LAP), lipid accumulation product ratio, and MetS. METHODS We detected the relationship between the Ty-G index, LAP, lipid ratio, and incidence of MetS. In addition, we classified the Ty-G index and LAP into tertiles to determine the efficacy of these indicators in predicting the risk of MetS. Finally, the effects of the Ty-G index, LAP, and lipid ratio on the prediction of MetS were evaluated with the receiver operating characteristic (ROC) curve. RESULTS Our results indicate that the incidence of MetS was 38% in 134 patients with PCOS, and that the Ty-G index, LAP, and lipid ratio were independent risk factors for MetS. In addition, the incidence of MetS significantly increased with Ty-G index and LAP. The ROC curve showed that the Ty-G index, LAP, and lipid ratio all showed good performance in predicting the occurrence of MetS in PCOS patients, but the Ty-G index had the highest predictive value, with a cut-off value of 8.70. CONCLUSIONS Our study revealed that the Ty-G index plays an important role in predicting the occurrence of MetS in PCOS patients. In addition, monitoring blood glucose and lipid levels is an effective approach for preventing MetS in PCOS patients clinically regardless of age, and weight management should be strictly implemented in overweight and obese patients to prevent MetS.
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Affiliation(s)
- Ning Ma
- Department of Obstetrics and Gynaecology, Yan'an University Affiliated Hospital, Yan'an, Shaanxi, China
| | - Xiao-Ning Cui
- Department of Obstetrics and Gynaecology, Yan'an People's Hospital, Yan'an, Shaanxi, China
| | - Na Wang
- Institute of Pathophysiology, Yan'an University, Yan'an, China
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23
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Sun C, Li N, Xiao X, Zhang Q. Association between lipid accumulation products and asthma among adults: Data from National Health and Nutrition Examination Survey (NHANES) 2003-2018. Respir Med 2025; 240:108017. [PMID: 40024334 DOI: 10.1016/j.rmed.2025.108017] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/13/2024] [Revised: 02/23/2025] [Accepted: 02/27/2025] [Indexed: 03/04/2025]
Abstract
OBJECTIVE The goal of our study was to investigate the potential relationship between Lipid Accumulation Product (LAP) and prevalence of asthma. DESIGN Cross-sectional study. SETTING The National Health and Nutrition Examination Survey (2003-2018). PARTICIPANTS The study included a total of 13,993 participants, all of whom had complete data on both asthma and LAP. BACKGROUND The Lipid accumulation product (LAP) index is a potential estimator of visceral fat accumulation. Overweight and obesity are the risk factors for asthma. However, no research investigated the possible correlation between LAP and the incidence of asthma. METHODS We undertook a cross-sectional analysis to investigate the link between LAP and asthma, utilizing data from the National Health and Nutrition Examination Surveys (NHANES 2003-2018). To address the complex, multistage, and clustered survey design, sample weights were incorporated into all the statistical analyses. The association between LAP and the prevalence of asthma was examined through multivariable logistic regression. Additionally, the linear correlation between these variables was assessed via smoothed curve fitting and threshold effect analyses. Subgroup analysis was conducted to identify any vulnerable populations. RESULTS The study included 13,993 participants, of whom 1965 (14.0 %) were diagnosed with asthma. Following adjustment for all covariates, a notable positive correlation emerged between the LAP index and asthma according to a multivariate logistic regression analysis. A heightened prevalence of asthma was observed with each unit increase in LnLAP (OR = 1.17, 95 % CI = 1.09-1.27, P < 0.001). Compared to individuals in the lowest LAP quartile, those in the highest quartile had a 34 % increased probability of developing asthma. (OR 1.34, 95 % CI 1.13-1.60, P = 0.001). Additionally, smoothed curve-fitting analysis revealed a nonlinear correlation between the LAP index and asthma. Through threshold effect analysis, the inflection point was established at 114.495. CONCLUSION The study found a positive association between the LAP index and asthma in adults, suggesting that LAP may serve as a potential biomarker for early detection of asthma and assessment of treatment efficacy.
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Affiliation(s)
- Chuang Sun
- Department of Respiratory and Critical Care Medicine, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, 213164, China
| | - Na Li
- Department of Respiratory and Critical Care Medicine, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, 213164, China
| | - Xinru Xiao
- Department of Respiratory and Critical Care Medicine, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, 213164, China
| | - Qian Zhang
- Department of Respiratory and Critical Care Medicine, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, 213164, China; Changzhou Medical Center, Nanjing Medical University, Changzhou, 213164, China.
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24
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Liu G, Cao L, Wen H, Liu M, He X, Wang M, Su Y, Xu F, Kong J, Piao C, Xu A, Zhang M, Hu F, Hu D, Zhao Y. Assessment of six surrogate insulin resistance indexes for predicting hypertension risk in rural Chinese adults. Hypertens Res 2025; 48:1285-1294. [PMID: 39953234 DOI: 10.1038/s41440-025-02147-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/28/2024] [Revised: 01/09/2025] [Accepted: 01/24/2025] [Indexed: 02/17/2025]
Abstract
Insulin resistance (IR) is a complex abnormality and associated with hypertension. We aimed to assess the associations of six alternate IR measures and risk of hypertension, and to compare the predictive values for hypertension. We assessed 11,223 non-hypertensive Chinese adults enrolled in The Rural Chinese Cohort Study during 2007-2008. Six surrogate IR indexes were new visceral adiposity index (NVAI), Chinese visceral adiposity index (CVAI), weight-adjusted waist index (WWI), lipid accumulation product (LAP), triglyceride glucose (TyG) index, and visceral adiposity index (VAI). The relative risks (RR) and 95% confidence intervals (95% CI) of the six IR indicators and hypertension were estimated by using modified Poisson regression models with three adjusted models. During a median follow-up of 11.1 years, 3373 (30.05%) study participants developed hypertension. The cumulative incidence of hypertension showed an increasing trend with higher levels of all six IR surrogates. Significant associations of all the IR measures with incident hypertension were found in fully adjusted model, and the highest quartile group RRs (95% CIs) for hypertension were, 2.19 (1.88-2.55), 1.60 (1.42-1.81), 1.38 (1.25-1.53), 1.47 (1.31-1.65), 1.18 (1.04-1.34) and 1.25 (1.08-1.44) for NVAI, CVAI, WWI, LAP, TyG index and VAI, respectively, compared with lowest quartile group. Further, NVAI had the maximum predictive power for hypertension among six IR measures with the largest AUC of 0.706 (0.697-0.714). NVAI, CVAI, WWI, LAP, and TyG index were all independently associated with greater risk of incident hypertension, among which NVAI is the most powerful predictor for hypertension in rural Chinese adults. Association of the surrogate insulin resistance indexes with the risk of hypertension.
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Affiliation(s)
- Ge Liu
- Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China
| | - Lu Cao
- Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China
| | - Hongwei Wen
- Zhengzhou Shuqing Medical College, Zhengzhou, Henan, PR China
| | - Mengna Liu
- Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China
| | - Xinxin He
- Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China
| | - Mengdi Wang
- Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China
| | - Yijia Su
- Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China
| | - Fan Xu
- Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China
| | - Jingli Kong
- Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China
| | - Canjie Piao
- Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China
| | - Aijun Xu
- Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China
| | - Ming Zhang
- Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Medical School, Shenzhen, Guangdong, PR China
| | - Fulan Hu
- Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Medical School, Shenzhen, Guangdong, PR China
| | - Dongsheng Hu
- Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China
| | - Yang Zhao
- Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
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25
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Wang SW, Wang C, Cheng YM, Hsieh TH, Wang CC, Kao JH. Liver and atherosclerotic risk of alcohol consumption in patients with metabolic dysfunction-associated Steatotic Liver Disease. Atherosclerosis 2025; 403:119161. [PMID: 40090036 DOI: 10.1016/j.atherosclerosis.2025.119161] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/24/2024] [Revised: 03/02/2025] [Accepted: 03/04/2025] [Indexed: 03/18/2025]
Abstract
BACKGROUND/PURPOSE A new disease name, "Steatotic Liver Disease (SLD)" was proposed in 2023. Within this algorithm, combined metabolic and alcoholic liver disease (MetALD) was named as a new specific subgroup. The clinical profiles and outcomes of MetALD patients are unknown. METHODS Participants from Taiwan Biobank database after exclusion those with positive for HBsAg, anti-HCV, and former drinkers were selected. MASLD was diagnosed if having hepatic steatosis on ultrasound plus at least one of cardiometabolic criteria. Increased or moderate alcohol intake was defined as continuous drinkers with alcohol consumption exceeding 210 g for men and 140 g for women weekly or below the levels, respectively. The fibrosis 4 (FIB-4) score was used to assess the severity of liver fibrosis, and carotid plaques on duplex ultrasound were employed to diagnose atherosclerosis. RESULTS In a total of 18,160 (mean age 55.28 ± 10.41; 33.2 % males) participants, there were 7316 (40.3 %) MASLD patients and 209 (1.2 %) MetALD patients. The participants with MetALD were younger and male predominant. After propensity score matching for age and gender, MetALD patients had higher AST, GGT, fatty liver index (FLI), and FIB-4 score and tended to have a higher proportion of carotid plaques than MASLD patients. Among MASLD patients, those with moderate alcohol intake had higher values of GGT, FLI, and FIB-4 score and a higher proportion of carotid plaques than those with no or social alcohol intake. CONCLUSIONS MetALD patients have a higher risk of liver injury than those with MASLD. Moreover, moderatet alcohol intake also increases the risk of liver injury and atherosclerotic in MASLD patients, suggesting MASLD patients should refrain from alcohol intake.
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Affiliation(s)
- Shao-Wen Wang
- Department of Education, Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare, Taiwan
| | - Ching Wang
- National Yang Ming Chiao Tung University, Taiwan
| | - Yu-Ming Cheng
- Department of Gastroenterology and Hepatology, Tung's Taichung MetroHarbor Hospital, Taiwan
| | - Tsung-Han Hsieh
- Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan
| | - Chia-Chi Wang
- Department of Gastroenterology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University, Hualien, Taiwan.
| | - Jia-Horng Kao
- Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
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26
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Giannakopoulou SP, Barkas F, Chrysohoou C, Liberopoulos E, Sfikakis PP, Pitsavos C, Tsioufis C, Panagiotakos D. Comparative analysis of obesity indices in discrimination and reclassification of cardiovascular disease risk: The ATTICA study (2002-2022). Eur J Intern Med 2025; 134:96-103. [PMID: 39939265 DOI: 10.1016/j.ejim.2025.02.007] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/28/2024] [Revised: 12/14/2024] [Accepted: 02/04/2025] [Indexed: 02/14/2025]
Abstract
BACKGROUND Despite the established link between obesity and cardiovascular disease (CVD), the optimal anthropometric index for risk prediction remains uncertain. AIMS This prospective cohort study aimed to compare various anthropometric indices for their association with 20-year atherosclerotic cardiovascular disease (ASCVD) risk in a healthy adult population and to assess their incremental predictive value. METHODS In 2002, n = 3,042 adults free of CVD, residing in Athens metropolitan area, in Greece, were recruited. A 20-year follow-up was conducted in 2022, comprising n = 2,169 participants, of which n = 1,845 had complete data on both CVD occurrence and anthropometric measures. RESULTS Almost all the studied anthropometric measures were significantly associated with 20-year ASCVD incidence. However, after full adjustment, none of these measures retained a significant association. The inclusion of any individual obesity index within the SCORE2 model enhanced the model's discriminatory power, while the continuous NRI exhibited positive values, suggesting improved risk reclassification. The indices linked to adipose tissue dysfunction exhibited greater efficacy in distinguishing and reclassifying CVD risk beyond SCORE2. Stratified analysis according to obesity and metabolic health status revealed that the optimal obesity index varies according to individual obesity and metabolic health profiles. CONCLUSION Obesity indices are strongly associated with long-term risk of ASCVD, underscoring the major role of excessive body fat in the pathogenesis of this condition. The inclusion of an obesity index in a CVD risk model significantly enhances its predictive accuracy and reclassification of risk, emphasizing the importance of these indices in refining CVD risk assessment among the general population.
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Affiliation(s)
- Sofia-Panagiota Giannakopoulou
- Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, 17676 Athens, Greece
| | - Fotios Barkas
- Department of Internal Medicine, Medical School, University of Ioannina, 45500 Ioannina, Greece
| | - Christina Chrysohoou
- First Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, 15772 Athens, Greece
| | - Evangelos Liberopoulos
- First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 15772 Athens, Greece
| | - Petros P Sfikakis
- First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 15772 Athens, Greece
| | - Christos Pitsavos
- First Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, 15772 Athens, Greece
| | - Costas Tsioufis
- First Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, 15772 Athens, Greece
| | - Demosthenes Panagiotakos
- Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, 17676 Athens, Greece.
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27
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Wiley CR, Pourmand V, Stevens SK, Jarczok MN, Fischer JE, Boschiero D, Poggiogalle E, Koenig J, Thayer JF, Williams DP. The interplay between heart rate variability, inflammation, and lipid accumulation: Implications for cardiometabolic risk. Physiol Rep 2025; 13:e70313. [PMID: 40285470 PMCID: PMC12032450 DOI: 10.14814/phy2.70313] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/26/2025] [Revised: 03/27/2025] [Accepted: 03/27/2025] [Indexed: 04/29/2025] Open
Abstract
Deleterious adiposity (e.g., obesity) is considered an inflammatory condition that increases risk for cardiovascular diseases. Lower heart rate variability (HRV), an independent predictor of cardiovascular disease risk, is linked with higher levels of adiposity and inflammation. However, indices of adiposity vary in their strength of association with disease risk. Body mass index (BMI) is a modest predictor of disease, while the lipid accumulation product (LAP) better predicts disease risk. The current investigation used cross-sectional and prospective designs to probe the differential associations between HRV and multiple measures of adiposity (e.g., LAP and BMI) and examine if inflammation (measured via C-reactive protein; CRP) mediated these associations. Study 1 showed that HRV was more strongly linked with LAP relative to other adiposity measures and that this link was mediated by CRP. Study 2 replicated Study 1 results and showed that this association remained significant 4 years later. Our novel findings are consistent with studies suggesting LAP may be a superior measure of cardiovascular disease risk relative to other measures of adiposity. Importantly, the strong link between HRV and LAP was mediated by inflammation, highlighting the key role of the cholinergic anti-inflammatory pathway in regulating obesity and associated health consequences.
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Affiliation(s)
- Cameron R. Wiley
- Department of Psychological ScienceUniversity of California, IrvineIrvineCaliforniaUSA
| | - Vida Pourmand
- Department of Psychological ScienceUniversity of California, IrvineIrvineCaliforniaUSA
| | - Sarah K. Stevens
- Department of Psychological ScienceUniversity of California, IrvineIrvineCaliforniaUSA
| | - Marc N. Jarczok
- Institute of Medical Psychology, Center for Psychosocial MedicineUniversity Hospital Heidelberg, Ruprecht‐Karls‐University HeidelbergHeidelbergGermany
- Department of Psychosomatic Medicine and PsychotherapyUlm University Medical CenterUlmGermany
| | - Joachim E. Fischer
- Mannheim Institute of Public Health, Social and Preventive MedicineMannheim Medical Faculty, Heidelberg UniversityMannheimGermany
| | - Dario Boschiero
- BIOTEKNA Biomedical TechnologiesVeniceItaly
- Open Academy of MedicineLondonUK
| | | | - Julian Koenig
- Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany
| | - Julian F. Thayer
- Department of Psychological ScienceUniversity of California, IrvineIrvineCaliforniaUSA
| | - DeWayne P. Williams
- Department of Psychological ScienceUniversity of California, IrvineIrvineCaliforniaUSA
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Zhang J, Wang Y, Guo J, Liu H, Lei Z, Cheng S, Cao H. The association between ten anthropometric measures and osteoporosis and osteopenia among postmenopausal women. Sci Rep 2025; 15:10994. [PMID: 40164628 PMCID: PMC11958737 DOI: 10.1038/s41598-025-94218-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/17/2024] [Accepted: 03/12/2025] [Indexed: 04/02/2025] Open
Abstract
Osteoporosis and osteopenia pose substantial public health challenges, particularly among postmenopausal women. Although various anthropometric measures have been proposed for risk assessment, their predictive performance and nonlinear relationships with bone outcomes remain unclear. We analyzed data from six consecutive cycles (2007-2018) of the National Health and Nutrition Examination Survey (NHANES). A total of 4473 postmenopausal women aged ≥ 50 years were included, each classified as having normal bone density, osteopenia, or osteoporosis based on dual-energy X-ray absorptiometry measurements. Ten anthropometric indices-waist-to-height ratio (WTHR), conicity index (CI), a body shape index (ABSI), body roundness index (BRI), lipid accumulation product, visceral adiposity index, cardiometabolic index, atherogenic index of plasma, weight-adjusted-waist index (WWI), and triglyceride-glucose (TyG) index-were examined using multiple logistic regression, restricted cubic spline curves, threshold-effect analyses, and SHAP (SHapley Additive exPlanations) analysis to assess their associations with osteoporosis and osteopenia. In fully adjusted models, individuals with higher WTHR, CI, BRI, WWI, and TyG tended to have a lower likelihood of osteoporosis or osteopenia (p < 0.01), whereas those with elevated ABSI were more likely to be diagnosed with these conditions (p < 0.01). Notably, several indices showed nonlinear effects on bone outcomes. Receiver operating characteristic (ROC) analyses indicated that WTHR and BRI had the highest discriminative capacity for differentiating osteoporosis from osteopenia. SHAP analysis further highlighted WTHR and BRI as the most influential predictors. WTHR and BRI demonstrated strong predictive utility for osteoporosis and osteopenia, suggesting their potential as noninvasive, cost-effective screening metrics for postmenopausal bone health. These findings provide insight into the varying roles of central and general obesity indicators in bone density and underscore the importance of incorporating novel anthropometric indices into early-stage risk assessment.
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Affiliation(s)
- Jingyuan Zhang
- Department of Traumatic Orthopedics, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, People's Republic of China
| | - Yuqi Wang
- Department of Traumatic Orthopedics, Weifang Yidu Central Hospital, Shiyan, 250000, People's Republic of China
| | - Jun Guo
- Department of Traumatic Orthopedics, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, People's Republic of China
| | - Heng Liu
- Department of Urology, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, People's Republic of China
| | - Zhuolin Lei
- Department of Traumatic Orthopedics, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, People's Republic of China
| | - Shouquan Cheng
- Department of Traumatic Orthopedics, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, People's Republic of China
| | - Hong Cao
- Department of Traumatic Orthopedics, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, People's Republic of China.
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Freitas de Medeiros S, Ferreira de Magalhães L, Yamamoto AKLW, Souto de Medeiros MA, Winck de Medeiros CL, Yamamoto MMW. Ethnicity Background of Women with Polycystic Ovary Syndrome: Comparison of Clinical, Endocrine, and Metabolic Characteristics. J Racial Ethn Health Disparities 2025:10.1007/s40615-025-02336-6. [PMID: 40164850 DOI: 10.1007/s40615-025-02336-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/17/2024] [Revised: 10/28/2024] [Accepted: 02/18/2025] [Indexed: 04/02/2025]
Abstract
OBJECTIVE To compare anthropometric, endocrine, and metabolic parameters among White, Black, and Mixed-race women who have polycystic ovary syndrome (PCOS). MATERIAL AND METHODS This cross-sectional study enrolled 392 Brazilian women of different races, 308 women with PCOS and 84 without PCOS. The proportions of differences in races/ethnicities between groups were compared using a chi-squared test with Bonferroni adjustment for the number of comparisons. Comparisons between PCOS and control in each race group were performed using Student t test or Z test where appropriate. Differences among more than two Gaussian variables were determined using one-way analysis of variance followed by a Tukey post hoc test. Age and body mass index as possible confounders of the found results were controlled using a multinominal logistic regression. RESULTS The proportions of ages and races were not different between women with PCOS and the control group (p = 0.099 and p = 0.978, respectively). Diastolic blood pressure was higher among Black women with PCOS (p < 0.001) and not different among Mixed-race (p = 0.667) or White (p = 0.133) races in the control group. Body weight, body mass index, waist circumference, waist-to-hip ratio, and fat mass were higher in Black women than in White women with PCOS (p < 0.05 for all comparisons). Free testosterone levels were higher among Black women than White women (p < 0.001) and Mixed-race women (p < 0.001) with PCOS, but the levels were not different in the control group. HbA1C was also higher among Black women with PCOS (p = 0.041). CONCLUSION Black women with PCOS presented higher concentrations of carbohydrate and lipid than White women. Regarding hormones, free testosterone levels and free androgen index were higher among Black women than among White and Mixed-race women with PCOS. The control group did not present anthropometric, metabolic, and endocrine differences among races. The findings of the current study strongly suggest that ethnic background has a wide implication in the development of comorbidities, diagnosis, or for the clinical assistance of women with PCOS. The analysis of race/ethnicity is recommended in future studies with focus on pathophysiological, biochemical, and clinical characteristics.
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Affiliation(s)
- Sebastião Freitas de Medeiros
- Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiabá, MT, 78043-306, Brazil.
- Tropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil.
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Gao S, He J, Liu H, Fan L, Tian R. Neutrophils as mediators of the association between lipid accumulation product and kidney stones, but not for recurrent kidney stones in US adults. Urolithiasis 2025; 53:62. [PMID: 40163111 DOI: 10.1007/s00240-025-01735-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/06/2025] [Accepted: 03/15/2025] [Indexed: 04/02/2025]
Abstract
Kidney stones (KS) are prevalent and often recur, with obesity, metabolic disorders, and inflammation significantly impacting their pathophysiology. The traditional body mass index (BMI) has limitations, as it cannot effectively differentiate between fat and lean body mass or provide information about fat distribution. In contrast, the lipid accumulation product (LAP), which combines waist circumference and triglyceride levels, serves as a crucial indicator of visceral fat. This study examines the relationship between LAP and KS, including recurrent kidney stones (RKS), using data from the National Health and Nutrition Examination Survey (NHANES). It also investigates whether neutrophils mediate the connection between LAP and KS/RKS, comparing the predictive accuracy of LAP and BMI. Data from 2007 to 2014 covered 9910 KS participants and 880 RKS participants. Weighted logistic regression assessed the LAP-KS/RKS relationship, while mediation analysis explored the role of neutrophils. Receiver Operating Characteristic (ROC) curves evaluated the predictive capabilities of LAP and BMI. Results showed LAP was significantly associated with KS (OR = 1.629; 95% CI 1.296-2.047) and RKS (OR = 1.561; 95% CI 1.145-2.128). Neutrophils partially mediated the LAP-KS relationship (7.6%, p = 0.018), with no effect found for RKS. Moreover, LAP outperformed BMI in diagnostic accuracy. These findings suggest that LAP is an effective marker for assessing KS and RKS, aiding in the early identification of potential patients to reduce the incidence and recurrence of kidney stones.
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Affiliation(s)
- Shang Gao
- Department of Urology, General Hospital of Northern Theater Command, No. 83, Wenhua Road, Shenyang, 110016, Liaoning, China
- Department of Graduate School, China Medical University, Shenyang, China
| | - Jingteng He
- Department of Urology, General Hospital of Northern Theater Command, No. 83, Wenhua Road, Shenyang, 110016, Liaoning, China
| | - Hongtao Liu
- Department of Urology, General Hospital of Northern Theater Command, No. 83, Wenhua Road, Shenyang, 110016, Liaoning, China
| | - Lianhui Fan
- Department of Urology, General Hospital of Northern Theater Command, No. 83, Wenhua Road, Shenyang, 110016, Liaoning, China.
| | - Renli Tian
- Department of Urology, General Hospital of Northern Theater Command, No. 83, Wenhua Road, Shenyang, 110016, Liaoning, China.
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Cao X, Xiao X, Jiang P, Fu N. Construction and evaluation of a diagnostic model for metabolic dysfunction-associated steatotic liver disease based on advanced glycation end products and their receptors. Front Med (Lausanne) 2025; 12:1539708. [PMID: 40224638 PMCID: PMC11985537 DOI: 10.3389/fmed.2025.1539708] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/04/2024] [Accepted: 03/14/2025] [Indexed: 04/15/2025] Open
Abstract
Background Effective biomarkers for the diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD) remain limited. This study aims to evaluate the potential of advanced glycation end products (AGEs) and their endogenous secretory receptor (esRAGE) as non-invasive biomarkers for diagnosing MASLD, to explore differences between obese and non-obese MASLD patients, and to develop a novel diagnostic model based on these biomarkers. Methods This study enrolled 341 participants, including 246 MASLD patients (118 non-obese, 128 obese) and 95 healthy controls. Serum AGEs and esRAGE levels were measured by ELISA. Key predictors were identified using the Lasso algorithm, and a diagnostic model was developed with logistic regression and visualized as nomograms. Diagnostic accuracy and utility were evaluated through the area under the curve (AUC), bootstrap validation, calibration curves, and decision curve analysis (DCA). Results Serum AGEs and esRAGE levels were significantly higher in MASLD patients compared to controls. Moreover, obese MASLD patients had higher esRAGE levels than non-obese ones, but no significant difference in AGEs levels was found. A diagnostic model incorporating age, WC, BMI, ALT, TG, HDL, AGEs, and esRAGE achieved an AUC of 0.963, with 94.3% sensitivity and 85.3% specificity. The AUC for bootstrap internal validation was 0.963 (95% CI: 0.944-0.982). Calibration curves showed strong predictive accuracy, and DCA demonstrated high net clinical benefit. Conclusion Serum AGEs and esRAGE serve as non-invasive biomarkers for distinguishing MASLD patients. We developed and validated diagnostic models for MASLD, offering valuable tools to identify at-risk populations and improve prevention and treatment strategies.
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Affiliation(s)
| | | | - Peipei Jiang
- Department of Gastroenterology, Hunan Provincial Clinical Research Center for Metabolic Associated Fatty Liver Diseases, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China
| | - Nian Fu
- Department of Gastroenterology, Hunan Provincial Clinical Research Center for Metabolic Associated Fatty Liver Diseases, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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Dăniluc L, Braha A, Sandu OE, Bogdan C, Suhov L, Haj Ali L, Lazăr-Höcher AI, Sima A, Apostol A, Ivan MV. Subclinical Changes in Type 2 Diabetes Patients with Heart Failure Stage A and B Treated with Oral Semaglutide. MEDICINA (KAUNAS, LITHUANIA) 2025; 61:567. [PMID: 40282858 PMCID: PMC12028782 DOI: 10.3390/medicina61040567] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 02/21/2025] [Revised: 03/16/2025] [Accepted: 03/21/2025] [Indexed: 04/29/2025]
Abstract
Background and Objectives: Heart failure (HF) among patients with type 2 diabetes (T2DM) is linked to significant morbidity and mortality, despite the increased availability of new drug therapy. This study aims to investigate subclinical changes in patients with HF stage A (at risk for HF) and B (Pre-HF) and T2DM treated with oral semaglutide. Materials and Methods: In a prospective, observational, single-center study, 50 T2DM patients were assessed at baseline and one-year follow-up for changes in spectral Doppler, tissue Doppler, and speckle-tracking (2DST) and metabolic parameters. Results: Correlation and regression analyses identified predictors of Δ GLS. In correlation analysis, Δ GLS showed a negative correlation with Δ VAI (rho = -0.3, p = 0.02), Δ LAP (rho = -0.3, p = 0.04), Δ FPG (rho = -0.3, p = 0.009), Δ TG (rho = -0.4, p = 0.004), and Δ TyG (rho = -0.3, p = 0.02). In linear stepwise regression analysis, the most accurate model, with a p-value < 0.001, was M3, explaining 70% of the variance in Δ GLS (adjusted R2 = 0.7); this model included Δ FPG (beta -0.4, p = 0.001), Δ CRR (beta -1.3, p < 0.001), and Δ LDLc (beta 0.6, p = 0.01). Conclusions: These findings show that improved subclinical left ventricular systolic dysfunction is associated with improved glycemic control, visceral adiposity, and reduced insulin resistance, respectively, with improved lipid profiling.
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Affiliation(s)
- Larissa Dăniluc
- Doctoral School, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania; (L.D.); (O.E.S.); (C.B.); (L.S.); (L.H.A.); (A.-I.L.-H.)
- Department of Cardiology, Pius Brinzeu Clinical Emergency County Hospital Timisoara, 300736 Timisoara, Romania; (A.A.); (M.V.I.)
- Department VII, Internal Medicine II, Discipline of Cardiology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timişoara, Romania
| | - Adina Braha
- Department of Second Internal Medicine Diabetes, Nutrition, Metabolic Diseases, and Systemic Rheumatology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania;
- Department of Diabetes, Nutrition and Metabolic Diseases Clinic, “Pius Brînzeu” Emergency Clinical County University Hospital, 300723 Timisoara, Romania
- Centre for Molecular Research in Nephrology and Vascular Disease/MOL-NEPHRO-VASC, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
| | - Oana Elena Sandu
- Doctoral School, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania; (L.D.); (O.E.S.); (C.B.); (L.S.); (L.H.A.); (A.-I.L.-H.)
- Department of Cardiology, Pius Brinzeu Clinical Emergency County Hospital Timisoara, 300736 Timisoara, Romania; (A.A.); (M.V.I.)
- Department VII, Internal Medicine II, Discipline of Cardiology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timişoara, Romania
| | - Carina Bogdan
- Doctoral School, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania; (L.D.); (O.E.S.); (C.B.); (L.S.); (L.H.A.); (A.-I.L.-H.)
- Department of Cardiology, Pius Brinzeu Clinical Emergency County Hospital Timisoara, 300736 Timisoara, Romania; (A.A.); (M.V.I.)
- Department VII, Internal Medicine II, Discipline of Cardiology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timişoara, Romania
| | - Loredana Suhov
- Doctoral School, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania; (L.D.); (O.E.S.); (C.B.); (L.S.); (L.H.A.); (A.-I.L.-H.)
- Department of Cardiology, Pius Brinzeu Clinical Emergency County Hospital Timisoara, 300736 Timisoara, Romania; (A.A.); (M.V.I.)
| | - Lina Haj Ali
- Doctoral School, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania; (L.D.); (O.E.S.); (C.B.); (L.S.); (L.H.A.); (A.-I.L.-H.)
- Department of Cardiology, Pius Brinzeu Clinical Emergency County Hospital Timisoara, 300736 Timisoara, Romania; (A.A.); (M.V.I.)
| | - Alexandra-Iulia Lazăr-Höcher
- Doctoral School, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania; (L.D.); (O.E.S.); (C.B.); (L.S.); (L.H.A.); (A.-I.L.-H.)
- Institute of Cardiovascular Diseases Timisoara, 300310 Timisoara, Romania
| | - Alexandra Sima
- Department of Second Internal Medicine Diabetes, Nutrition, Metabolic Diseases, and Systemic Rheumatology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania;
- Department of Diabetes, Nutrition and Metabolic Diseases Clinic, “Pius Brînzeu” Emergency Clinical County University Hospital, 300723 Timisoara, Romania
| | - Adrian Apostol
- Department of Cardiology, Pius Brinzeu Clinical Emergency County Hospital Timisoara, 300736 Timisoara, Romania; (A.A.); (M.V.I.)
- Department VII, Internal Medicine II, Discipline of Cardiology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timişoara, Romania
| | - Mihaela Viviana Ivan
- Department of Cardiology, Pius Brinzeu Clinical Emergency County Hospital Timisoara, 300736 Timisoara, Romania; (A.A.); (M.V.I.)
- Department VII, Internal Medicine II, Discipline of Cardiology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timişoara, Romania
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Kong X, Wang W. L-shaped association between lipid accumulation products and depression: Insights from the National Health and nutrition examination survey 2005-2018. J Affect Disord 2025; 373:44-50. [PMID: 39722331 DOI: 10.1016/j.jad.2024.12.081] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/01/2024] [Revised: 12/02/2024] [Accepted: 12/20/2024] [Indexed: 12/28/2024]
Abstract
BACKGROUND Increasing studies have indicated that insulin resistance is a risk factor for the development of depression. The lipid accumulation product (LAP) has emerged as a novel biomarker of insulin resistance. This cross-sectional study aimed to explore the relationship between LAP and the risk of depression. METHODS Data of adult participants from the 2005-2018 National Health and Nutrition Examination Survey were obtained. Depression presence and severity were evaluated using the 9-item Patient Health Questionnaire (PHQ-9). The linear and non-linear associations between LAP and PHQ-9 scores were evaluated using multivariable logistic regression analysis, restricted cubic spline analysis, and piecewise regression analysis. RESULTS A total of 2073 participants with and 22,714 without depression were included. The association between LAP and risk of depression was L-shaped. Piecewise regression analysis showed that the odds ratio and 95 % confidence interval for the association between LAP and PHQ-9 score were 1.008 (1.004, 1.012) for LAP <140.16 cm × mmol/L and 1.001 (0.999, 1.004) for LAP >140.16 cm × mmol/L. Subgroup analysis indicated that the association between LAP and PHQ-9 score was more pronounced in women than in men, and more pronounced in never smokers than in former and current smokers. LIMITATION Cross-sectional design that limited interpretation of causal relationships. CONCLUSIONS LAP was an independent risk factor for depression in US adults when it was <140.16 cm × mmol/L, especially in women and never smokers. Prospective, longitudinal studies are needed to establish a causal relationship between LAP and depression.
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Affiliation(s)
- Xiufang Kong
- Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China
| | - Wei Wang
- Department of Nephrology, Shanghai Tenth People's Hospital, Shanghai 200032, China.
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Deng Z, Tian X, Xiong T, Mao Q, Zhu X, Kong Y. Association between lipid accumulation product index and the prevalence of cardiovascular diseases induced by 2-hydroxyfluorene: A cross-sectional study from the NHANES (2005-2016). Medicine (Baltimore) 2025; 104:e41681. [PMID: 40101054 PMCID: PMC11922466 DOI: 10.1097/md.0000000000041681] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/09/2024] [Accepted: 02/07/2025] [Indexed: 03/20/2025] Open
Abstract
This research explored the effects of 2-hydroxyfluorene exposure on the incidence of cardiovascular diseases (CVDs), particularly examining the mediating role of the lipid accumulation product (LAP) index. Utilizing data from the National Health and Nutrition Examination Survey spanning 2005 to 2018, this analysis evaluated the impact of 2-hydroxyfluorene on CVDs prevalence employing a variety of statistical methods. Logistic regression was applied to investigate relationships within polycyclic aromatic hydrocarbon mixtures, complemented by Bayesian Kernel Machine Regression. Additionally, a mediation analysis explored the influence of the LAP index in moderating the effects of 2-hydroxyfluorene on CVDs prevalence. The research also detailed the link between 2-hydroxyfluorene exposure and specific CVDs such as congestive heart failure, myocardial infarction, angina pectoris, and coronary heart disease, including their mediated impacts. Involving 3653 participants, the study detected a robust positive correlation between 2-hydroxyfluorene exposure and overall CVD risk (OR [95%CI] = 393.5173 [23.6978-6534.5979], P < .0001). This association extended to the prevalence of specific types of CVDs. The LAP index served as a mediator in the connection between 2-hydroxyfluorene exposure and the prevalence of total CVD, congestive heart failure, myocardial infarction, coronary heart disease, and stroke, with mediation percentages of 12%, 10%, 100%, 5%, and 9%, respectively. These results underscore a significant link between 2-hydroxyfluorene exposure and increased prevalence of CVDs, with the LAP index playing a crucial mediating role.
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Affiliation(s)
- Zhuofan Deng
- Department of Hepatobiliary Surgery, The Chengdu Sixth People’s Hospital, Chengdu, China
| | - Xinling Tian
- Xiangya School of Medicine, Central South University, Changsha, China
| | - Tian Xiong
- Xiangya School of Medicine, Central South University, Changsha, China
| | - Qingsong Mao
- Hepatobiliary Pancreatic Surgery, Banan Hospital Affiliated to Chongqing Medical University, Chongqing, China
| | - Xiaoyi Zhu
- Xiangya School of Medicine, Central South University, Changsha, China
| | - Yuzhe Kong
- Xiangya School of Medicine, Central South University, Changsha, China
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Huang Y, Zhao D, Yang Z, Wei C, Qiu X. The relationship between VAI, LAP, and depression and the mediation role of sleep duration-evidence from NHANES 2005-2020. BMC Psychiatry 2025; 25:228. [PMID: 40069662 PMCID: PMC11899296 DOI: 10.1186/s12888-025-06631-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/31/2024] [Accepted: 02/19/2025] [Indexed: 03/14/2025] Open
Abstract
BACKGROUND The relationship between obesity and mental health has attracted attention. However, large sample studies on the relationship between visceral fat obesity and depression are lacking. This study aimed to explore the relationship between visceral fat obesity and depression by using visceral adiposity index (VAI) and lipid accumulation product (LAP). Additionally, it sought to explore the potential mediating role of sleep duration in these associations. METHODS The data used in the current cross-sectional investigation are from the National Health and Nutrition Examination Survey (NHANES) spanning from 2005 to 2020, including 19,659 participants. Depression was measured using the nine-item Patient Health Questionnaire. Weighted multivariable regression analysis was used to evaluate the correlation of VAI and LAP with depression. The potential non-linear relationship was determined using smooth curve fitting and threshold effect analysis. Additionally, mediation analysis was performed to investigate the potential mediating role of sleep duration. The stability of the relationship was assessed through sensitivity analysis. RESULTS VAI and LAP were closely related to depression. In the fully adjusted model, VAI and LAP in the highest quartile increased the association of depression by 52% (OR = 1.52, 95% CI 1.20-1.92, P < 0.001) and 51% (OR = 1.51, 95% CI 1.19-1.91, P < 0.001), respectively, compared with the lowest quartile. Specific saturation effects for VAI, LAP, and depression were identified by smoothed curve fitting, with inflection points of 3.81 and 98.55, respectively. Additionally, mediation analysis revealed that 5.1% and 2.8% of the associations between VAI and LAP with depression were mediated through sleep duration. The results of the sensitivity analysis showed interactions between hypertension and cardiovascular disease in the associations of VAI, and depression (P < 0.05). CONCLUSION VAI and LAP are associated with depression in US adults. The associations between VAI and LAP with depression are non-linear, which may be mediated through sleep duration. The study highlights the potential of VAI and LAP as valuable tools for the prevention and management of depression.
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Affiliation(s)
- Yiqing Huang
- Medical School, Shenzhen University, No.1066, Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong Province, 518060, People's Republic of China
| | - Dan Zhao
- Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
| | - Zhongfang Yang
- School of Nursing, Fudan University, 305 Fenglin Road, Shanghai, 200032, China
| | - Changning Wei
- School of Tech X Academy, Shenzhen Polytechnic University, Shenzhen, China
| | - Xichenhui Qiu
- Medical School, Shenzhen University, No.1066, Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong Province, 518060, People's Republic of China.
- Rory Meyers College of Nursing, New York University, New York, NY, 10010, USA.
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Wang L, Liu S, Ke J, Cao B, Wang D, Zhao Q, Gong H, Fang Y, Zheng Z, Yu C, Wu N, Ma Y, Yu K, Yang L, Zhao D. Association between metabolic visceral fat score and left ventricular hypertrophy in individuals with type 2 diabetes. Diabetol Metab Syndr 2025; 17:81. [PMID: 40050939 PMCID: PMC11884144 DOI: 10.1186/s13098-025-01648-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/24/2024] [Accepted: 02/19/2025] [Indexed: 03/10/2025] Open
Abstract
BACKGROUND Left ventricular hypertrophy (LVH), a hallmark of early-stage heart failure (HF), is a common complication in individuals with type 2 diabetes mellitus (T2DM). Metabolic Visceral Fat Score (METS-VF), a novel metric for estimating visceral adiposity, may provide valuable insights into LVH risk. This study explores the association between METS-VF and LVH in T2DM and compare its predictive performance to traditional abdominal obesity indices. METHODS This cross-sectional study included 4,988 adults with T2DM. Participants were stratified into quartiles based on METS-VF. Logistic regression models assessed the association between METS-VF and LVH. Restricted cubic spline analyses evaluated nonlinear relationships, while stratified analyses explored subgroups effects. Receiver operating characteristic (ROC) curves compared the predictive performance of METS-VF with other indices. RESULTS LVH prevalence increased across METS-VF quartiles (Quartile 1: 7.9%; Quartile 2: 13.0%; Quartile 3: 20.0%; Quartile 4: 31.0%; P < 0.001). Higher METS-VF was independently associated with LVH (OR: 9.79; 95% CI: 6.16-15.76; P < 0.001). A nonlinear relationship was observed between METS-VF and LVH, with a steeper risk increase above specific thresholds. Stratified analyses showed that the positive association between METS-VF and LVH was consistent. METS-VF outperformed traditional indices in predicting LVH (AUC: 0.68; 95% CI: 0.66-0.70). CONCLUSIONS METS-VF is strongly associated with LVH in T2DM, demonstrating superior predictive performance compared to traditional indices. METS-VF is a practical, cost-effective tool for early cardiac risk stratification, facilitating timely interventions to mitigate HF risk in T2DM populations.
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Affiliation(s)
- Lu Wang
- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China
| | - Simo Liu
- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China
| | - Jing Ke
- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China
| | - Bin Cao
- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China
| | - Di Wang
- Beijing Key Laboratory of Diabetes Research and Care, Beijing, 101149, China
| | - Qianqian Zhao
- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China
| | - Haolin Gong
- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China
| | - Yuan Fang
- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China
| | - Zhaohui Zheng
- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China
| | - Caiguo Yu
- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China
| | - Nannan Wu
- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China
| | - Yan Ma
- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China
| | - Ke Yu
- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China
| | - Longyan Yang
- Beijing Key Laboratory of Diabetes Research and Care, Beijing, 101149, China
| | - Dong Zhao
- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China.
- Beijing Key Laboratory of Diabetes Research and Care, Beijing, 101149, China.
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Guo FS, Guo C, Dou JH, Wang JX, Wu RY, Song SF, Sun XL, Hu YW, Wei J. Association of surrogate adiposity markers with prevalence, all-cause mortality and long-term survival of heart failure: a retrospective study from NHANES database. Front Endocrinol (Lausanne) 2025; 16:1430277. [PMID: 40104133 PMCID: PMC11913658 DOI: 10.3389/fendo.2025.1430277] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/09/2024] [Accepted: 02/13/2025] [Indexed: 03/20/2025] Open
Abstract
Introduction Obesity, especially abdominal obesity, is more common in patients with heart failure (HF), but body mass index (BMI) cannot accurately describe fat distribution. Several surrogate adiposity markers are available to reflect fat distribution and quantity. The objective of this study was to explore which adiposity marker is most highly correlated with HF prevalence, all-cause mortality and patients' long-term survival. Methods The National Health and Nutrition Examination Survey (NHANES) database provided all the data for this study. Logistic regression analyses were adopted to compare the association of each surrogate adiposity marker with the prevalence of HF. Cox proportional hazards models and restricted cubic spline (RCS) analysis were employed to assess the association between surrogate adiposity markers and all-cause mortality in HF patients. The ability of surrogate adiposity markers to predict long-term survival in HF patients was assessed using time-dependent receiver operating characteristic (ROC) curves. Results 46,257 participants (1,366 HF patients) were encompassed in this retrospective study. An area under the receiver operating characteristic curve (AUC) for the prevalence of HF assessed by weight-adjusted-waist index (WWI) was 0.70 (95% CI: 0.69-0.72). During a median follow-up of 70 months, 700 of 1366 HF patients' death were recorded. The hazard ratio (HR) for HF patients' all-cause mortality was 1.33 (95% CI: 1.06-1.66) in the a body shape index (ABSI) quartile 4 group and 1.43 (95% CI: 1.13-1.82) in the WWI quartile 4 group, compared with the lowest quartile group. The AUC for predicting 5-year survival of HF patients using the ABSI was 0.647 (95% CI: 0.61-0.68). Conclusions WWI is strongly correlated with the prevalence of HF. In HF patients, those with higher WWI and ABSI tend to higher all-cause mortality. ABSI can predict patients' long-term survival. We recommend the use of WWI and ABSI for assessing obesity in HF patients.
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Affiliation(s)
- Fan-Shun Guo
- Department of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
- Clinical Research Center for Endemic Disease of Shaanxi Province, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
| | - Chen Guo
- Department of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
- Clinical Research Center for Endemic Disease of Shaanxi Province, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
| | - Jia-Hao Dou
- Department of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
- Clinical Research Center for Endemic Disease of Shaanxi Province, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
| | - Jun-Xiang Wang
- Medicine Department of Xi’an Jiaotong University, Xi’an, Shaanxi, China
| | - Rui-Yun Wu
- Department of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
- Clinical Research Center for Endemic Disease of Shaanxi Province, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
| | - Shou-Fang Song
- Department of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
- Clinical Research Center for Endemic Disease of Shaanxi Province, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
| | - Xue-Lu Sun
- Department of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
- Clinical Research Center for Endemic Disease of Shaanxi Province, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
| | - Yi-Wei Hu
- Department of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
- Clinical Research Center for Endemic Disease of Shaanxi Province, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
| | - Jin Wei
- Department of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
- Clinical Research Center for Endemic Disease of Shaanxi Province, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
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Wu X, Song Y, Wu S. The development and evaluation of nine obesity-based indices for gallstones in U.S. adults. Int J Surg 2025; 111:2348-2357. [PMID: 39869395 DOI: 10.1097/js9.0000000000002237] [Citation(s) in RCA: 2] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/26/2024] [Accepted: 11/29/2024] [Indexed: 01/28/2025]
Abstract
OBJECTIVE Gallstones have gradually become a highly prevalent digestive disease worldwide. This study aimed to investigate the association of nine different obesity-related indicators (BRI, RFM, BMI, WC, LAP, CMI, VAI, AIP, TyG) with gallstones and to compare their predictive properties for screening gallstones. METHODS Data for this study were obtained from the National Health and Nutrition Examination Survey (NHANES) for the 2017-2020 cycle, and weighted logistic regression analyses with multi-model adjustment were conducted to explore the association of the nine indicators with gallstones. Subject working curves were analyzed to assess the screening ability of the nine indicators. In addition, the association between the most predictive indicator and gallstones was investigated with smooth curve fitting, and differences in risk across populations were explored with subgroup analyses. RESULTS In total, 3654 participants were involved in the final analysis and 383 (10.48%) carried gallstones. The results of weighted multifactorial logistic regression analysis indicated that BRI, RFM, BMI, WC, LAP, and CMI were independent risk factors for gallstones. The ORs for the highest quartile were 4.13 for RFM, 3.13 for BRI, 2.85 for BMI, 2.86 for WC, 2.45 for LAP, and 1.49 for CMI. The area under the ROC curve for RFM was 0.70. The Delong test compared the performance of different ROCs and revealed that the difference between the area under the curve of RFM and the other metrics was significant ( P < 0.05). Smooth curve fitting suggested a linear positive correlation between RFM and gallstones (LLR > 0.05), especially in women, non-Hispanic White, insufficient physical activity, hypertensive, and diabetic populations. CONCLUSION RFM, BRI, BMI, WC, LAP, and CMI were essential indicators for recognizing gallstones. By comparison, we realized that RFM was a better predictor of gallstones.
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Affiliation(s)
| | - Yanhong Song
- Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, China
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Ruiz-García A, Arranz-Martínez E, Serrano-Cumplido A, Cinza-Sanjurjo S, Escobar-Cervantes C, Polo-García J, Pallarés-Carratalá V. From Metabolic Syndrome to Cardio-Kidney-Metabolic Syndrome in the SIMETAP Study: Prevalence Rates of Metabolic Syndrome and Its Independent Associations with Cardio-Renal-Metabolic Disorders Other than Its Defining Criteria. Biomedicines 2025; 13:590. [PMID: 40149567 PMCID: PMC11939902 DOI: 10.3390/biomedicines13030590] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/22/2025] [Revised: 02/23/2025] [Accepted: 02/24/2025] [Indexed: 03/29/2025] Open
Abstract
Background/Objectives: Metabolic syndrome (MetS) is a highly prevalent entity defined according to cardiometabolic criteria. Other disorders related to MetS could help assess the comprehensive risk of diabetes, cardiovascular disease, and chronic kidney disease (CKD). This study aimed to update the prevalence rates of MetS and to assess its relationship with other disorders and clinical conditions other than the criteria defining MetS. Methods: A cross-sectional observational study was conducted with a random population-based sample of 6588 study subjects between 18 and 102 years of age. Crude and sex- and age-adjusted prevalence rates of MetS were calculated, and their associations with comorbidities and clinical conditions other than their defining criteria were assessed by bivariate and multivariate analysis. Results: The adjusted prevalence rates were 36.0% for MetS (39.8% in men; 33.5% in women), 21.5% for premorbid Mets, and 14.5% for morbid MetS. Considering only clinical conditions other than the criteria defining MetS, the independent disorders associated with premorbid MetS were hypercholesterolemia, hypertension, high levels of lipid accumulation product, high triglyceride-glucose index (TyG), high visceral adiposity index, high fatty liver index, and high waist-to-height ratio (WtHR), highlighting excess adiposity (EA). The independent disorders associated with morbid MetS were hypercholesterolaemia, high-WtHR, EA, high-TyG index, heart failure, atrial fibrillation, CKD, and albuminuria, highlighting hypertension. Conclusions: One-fifth of the adult population has premorbid MetS, and almost one-sixth has morbid MetS. Almost two-fifths of people with MetS are at moderate, high, or very high risk of CKD, and four-fifths are at high or very high cardiovascular risk. In addition to the criteria defining MetS, other cardiovascular-renal-metabolic disorders show an independent association with MetS, highlighting EA for premorbid MetS and hypertension for morbid MetS.
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Affiliation(s)
- Antonio Ruiz-García
- Lipids and Cardiovascular Prevention Unit, Pinto University Health Centre, 28320 Madrid, Spain
- Department of Medicine, European University of Madrid, 28005 Madrid, Spain
| | | | | | - Sergio Cinza-Sanjurjo
- Milladoiro Health Centre, Health Area of Santiago de Compostela, 15895 Ames, Spain;
- Department of Medicine, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain
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Zhu X, Li C, Wang X, Yang Z, Liu Y, Zhao L, Zhang X, Peng Y, Li X, Yi H, Guan J, Yin S, Xu H. Accessible moderate-to-severe obstructive sleep apnea screening tool using multidimensional obesity indicators as compact representations. iScience 2025; 28:111841. [PMID: 39981513 PMCID: PMC11841217 DOI: 10.1016/j.isci.2025.111841] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/09/2024] [Revised: 08/27/2024] [Accepted: 01/16/2025] [Indexed: 02/22/2025] Open
Abstract
Many obesity indicators have been linked to adiposity and its distribution. Utilizing a combination of multidimensional obesity indicators may yield different values to assess the risk of moderate-to-severe obstructive sleep apnea (OSA). We aimed to develop and validate the performances of automated machine-learning models for moderate-to-severe OSA, employing multidimensional obesity indicators as compact representations. We trained, validated, and tested models with logistic regression and other 5 machine learning algorithms on the clinical dataset and a community dataset. Light gradient boosting machine (LGB) had better performance of calibration and clinical utility than other algorithms in both clinical and community datasets. The model with the LGB algorithm demonstrated the feasibility of predicting moderate-to-severe OSA with considerable accuracy using 19 obesity indicators in clinical and community settings. The useable interface with deployment of the best performing model could scale-up well into real-word practice and help effectively detection for undiagnosed moderate-to-severe OSA.
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Affiliation(s)
- Xiaoyue Zhu
- Department of Otolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Otolaryngological Institute of Shanghai Jiao Tong University, Shanghai, China
| | - Chenyang Li
- Department of Otolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Otolaryngological Institute of Shanghai Jiao Tong University, Shanghai, China
| | - Xiaoting Wang
- Department of Otolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Otolaryngological Institute of Shanghai Jiao Tong University, Shanghai, China
| | - Zhipeng Yang
- School of Software, Fudan University, Shanghai, China
| | - Yupu Liu
- Department of Otolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Otolaryngological Institute of Shanghai Jiao Tong University, Shanghai, China
| | - Lei Zhao
- School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China
| | - Xiaoman Zhang
- Department of Otolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Otolaryngological Institute of Shanghai Jiao Tong University, Shanghai, China
| | - Yu Peng
- Department of Otolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Otolaryngological Institute of Shanghai Jiao Tong University, Shanghai, China
| | - Xinyi Li
- Department of Otolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Otolaryngological Institute of Shanghai Jiao Tong University, Shanghai, China
| | - Hongliang Yi
- Department of Otolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Otolaryngological Institute of Shanghai Jiao Tong University, Shanghai, China
| | - Jian Guan
- Department of Otolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Otolaryngological Institute of Shanghai Jiao Tong University, Shanghai, China
| | - Shankai Yin
- Department of Otolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Otolaryngological Institute of Shanghai Jiao Tong University, Shanghai, China
| | - Huajun Xu
- Department of Otolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Otolaryngological Institute of Shanghai Jiao Tong University, Shanghai, China
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Lajeunesse-Trempe F, Dugas S, Maltais-Payette I, Tremblay ÈJ, Piché ME, Dimitriadis GK, Lafortune A, Marceau S, Biertho L, Tchernof A. Anthropometric Indices and Metabolic Dysfunction-Associated Fatty Liver Disease in Males and Females Living With Severe Obesity. Can J Gastroenterol Hepatol 2025; 2025:5545227. [PMID: 39989658 PMCID: PMC11847611 DOI: 10.1155/cjgh/5545227] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/23/2023] [Revised: 05/28/2024] [Accepted: 11/07/2024] [Indexed: 02/25/2025] Open
Abstract
Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD) is highly prevalent among people living with severe obesity (body mass index [BMI] ≥ 35 kg/m2). However, it remains unknown how sex and adipose tissue distribution are related to MAFLD onset and progression into metabolic dysfunction-associated steatohepatitis (MASH) or advanced stages of fibrosis. Methodology: We retrospectively studied patients with severe obesity who were eligible for bariatric surgery. Demographic characteristics, biomarkers, and cardiometabolic comorbidities were reported. Anthropometric indices such as BMI, waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), neck circumference (NC), lipid accumulation product (LAP), visceral adiposity index (VAI), body adiposity index (BAI), abdominal volume index (AVI), and body roundness index (BRI) were measured or calculated. MAFLD, MASH, and stages of fibrosis (F1-F4) were established from perioperative liver biopsies. Standardized univariate and multivariate logistic regression analyses were used to examine the association between demographic variables, anthropometric indices, cardiometabolic conditions, and the risk of MASH or severe fibrosis (F2-F4). Results: A total of 2091 participants with severe obesity were included in the analyses; BMI 47.9 ± 7.3 kg/m2, age 46.2 ± 11.2 years, and 68.4% females. Overall, MAFLD prevalence was 79.5%, with 44.5% having MASH and 24.4% having severe fibrosis (Stage 2 or higher). No anthropometric indices of adiposity were associated with MASH or fibrosis severity. In this population, female sex was a risk factor for severe fibrosis (OR: 1.27, 95% CI 1.01-1.59, p < 0.05). Conclusions: MAFLD and MASH are highly prevalent in individuals living with severe obesity, but no anthropometric indices or laboratory tests are good predictors of MAFLD or MASH in this population. When MAFLD is diagnosed, our results suggest that females with severe obesity might be at higher risk of advanced stages of fibrosis.
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Affiliation(s)
- Fannie Lajeunesse-Trempe
- Department of Specialized Medicine, Internal Medicine, Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
- Faculty of Agriculture and Food Sciences, School of Nutrition, Laval University, Quebec City, Quebec, Canada
- Faculty of Life Sciences and Medicine, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK
| | - Selena Dugas
- Faculty of Agriculture and Food Sciences, School of Nutrition, Laval University, Quebec City, Quebec, Canada
| | - Ina Maltais-Payette
- Faculty of Agriculture and Food Sciences, School of Nutrition, Laval University, Quebec City, Quebec, Canada
| | - Ève-Julie Tremblay
- Faculty of Agriculture and Food Sciences, School of Nutrition, Laval University, Quebec City, Quebec, Canada
| | - Marie-Eve Piché
- Department of Medicine, Laval University, Quebec City, Quebec, Canada
| | - Georgios K. Dimitriadis
- Faculty of Life Sciences and Medicine, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK
- Department of Endocrinology, King's College Hospital NHS Foundation Trust, London, UK
| | - Annie Lafortune
- Department of Surgery, Laval University, Quebec City, Quebec, Canada
| | - Simon Marceau
- Department of Surgery, Laval University, Quebec City, Quebec, Canada
| | - Laurent Biertho
- Department of Surgery, Laval University, Quebec City, Quebec, Canada
| | - André Tchernof
- Faculty of Agriculture and Food Sciences, School of Nutrition, Laval University, Quebec City, Quebec, Canada
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Kang Z, Ye Y, Xiao H, Liu L. The relationship between frailty and major adverse cardiovascular and cerebrovascular events in Chinese older adults: the mediating effect of lipid accumulation products. Arch Public Health 2025; 83:33. [PMID: 39939980 DOI: 10.1186/s13690-025-01520-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/26/2024] [Accepted: 01/29/2025] [Indexed: 02/14/2025] Open
Abstract
BACKGROUND Previous studies have proven the relationship between frailty and major adverse cardiovascular and cerebrovascular events (MACCE). However, the potential mechanisms need to be further explored. This study aimed to investigate the mediating effect of lipid accumulation products (LAP) in the relationship between frailty and MACCE. METHODS This study recruited 7901 participants aged 45 and above from wave 2011 and 2018 of the China Longitudinal Study of Health and Retirement (CHARLS). Logistic regression models were employed to examine the relationship between frailty and MACCE and the mediating effects of LAP, using the bootstrap method to confirm path effects. RESULTS Frailty group presented the highest risk of MACCE (OR 1.07, 95% CI 1.03-1.10). Frailty directly impacted MACCE (β = 0.045, P = 0.007). Frailty had a significant effect on LAP (β = 12.21, P < 0.01), while LAP had a significant impact on MACCE (β = 11.14, p = 0.014). The mediation effect of LAP accounted for 1.7% of the total effect regarding the frailty with MACCE. CONCLUSION LAP mediate the relationship between frailty and MACCE. Our findings suggest that instructing frailty patients to have a reasonable diet and exercise to control LAP at a low level may be an effective measure to reduce MACCE.
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Affiliation(s)
- Zhoucheng Kang
- Department of Neurology, No.989 Hospital of Joint Logistic Support Force of PLA, Luoyang, China
| | - Yongli Ye
- Department of Urinary Surgery, No.989 Hospital of Joint Logistic Support Force of PLA, Luoyang, China
| | - Hao Xiao
- Department of Critical Care, No.989 Hospital of Joint Logistic Support Force of PLA, Luoyang, China
| | - Lingling Liu
- Department of Burn and Plastic Surgery, No.980 Hospital of Joint Logistic Support Force of PLA, No.398 Zhongshan Road West, Shijiazhuang, 050082, Hebei Province, China.
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Ferreira JRS, Libardi MC, do Prado CB, Zandonade E, Bezerra OMDPA, Salaroli LB. Predicting metabolic syndrome by lipid accumulation product, visceral adiposity index and body roundness index in Brazilian rural workers. BMC Public Health 2025; 25:544. [PMID: 39930422 PMCID: PMC11812240 DOI: 10.1186/s12889-025-21624-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/18/2024] [Accepted: 01/24/2025] [Indexed: 02/13/2025] Open
Abstract
BACKGROUND Anthropometric indicators, such as the Lipid Accumulation Product (LAP), the Visceral Adiposity Index (VAI), and the Body Roundness Index (BRI), could be valuable tools for identifying metabolic syndrome (MS) in rural populations because of their simplicity, low cost, and ability to identify central obesity and related metabolic risks where access to healthcare is limited. This study aimed to evaluate the predictive capacity of three anthropometric indices for identifying MS in a representative sample of rural workers in Espírito Santo, Brazil. METHODS A cross-sectional analysis was conducted, and the diagnostic performance of these indices was assessed via ROC curves under the NCEP and IDF criteria for MS. The study involved 806 participants, aged 18-59 years, and the data collection included anthropometric measurements, biochemical tests, and blood pressure assessments. RESULTS The results showed that LAP had the highest discriminatory capacity for MS under both diagnostic criteria, with AUCs of 0.803 (NCEP) and 0.885 (IDF), followed by BRI and VAI. The cutoff points identified for LAP were 33.84 (NCEP) and 26.80 (IDF), with high sensitivity and specificity. The BRI also demonstrated strong predictive power with AUC values above 0.7, whereas the VAI had the lowest AUC among the indices but remained a useful predictor. The correlations between the indices and MS components highlighted significant relationships, especially between LAP and triglycerides (r = 0.830). CONCLUSIONS This is the first study to determine cutoff points for these indices in a rural Brazilian population, suggesting that LAP and BRI are reliable tools for MS screening. The low cost of these methods could aid in improving healthcare accessibility and prevention strategies in rural areas with limited resources. Future research is recommended to validate these findings in other populations.
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Affiliation(s)
- Júlia Rabelo Santos Ferreira
- Graduate Program in Public Health, Federal University of Espírito Santo, Marechal Campos Avenue, 1468, Maruípe, Vitória, ES, Brazil.
| | - Manoela Cassa Libardi
- Graduate Program in Public Health, Federal University of Espírito Santo, Marechal Campos Avenue, 1468, Maruípe, Vitória, ES, Brazil
| | - Camila Bruneli do Prado
- Graduate Program in Public Health, Federal University of Espírito Santo, Marechal Campos Avenue, 1468, Maruípe, Vitória, ES, Brazil
| | - Eliana Zandonade
- Graduate Program in Public Health, Federal University of Espírito Santo, Marechal Campos Avenue, 1468, Maruípe, Vitória, ES, Brazil
| | | | - Luciane Bresciani Salaroli
- Graduate Program in Public Health, Federal University of Espírito Santo, Marechal Campos Avenue, 1468, Maruípe, Vitória, ES, Brazil
- Graduate Program in Nutrition and Health, Federal University of Espírito Santo, Vitória, ES, Brazil
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Cândido FG, da Silva A, Zanirate GA, Oliveira NMCE, Hermsdorff HHM. Lymphocyte to High-density Lipoprotein Cholesterol Ratio is Positively Associated with Pre-diabetes, Metabolic Syndrome, and Non-traditional Cardiometabolic Risk Markers: A Cross-sectional Study at Secondary Health Care. Inflammation 2025; 48:276-287. [PMID: 38844648 DOI: 10.1007/s10753-024-02063-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/03/2024] [Revised: 04/22/2024] [Accepted: 05/23/2024] [Indexed: 07/30/2024]
Abstract
High scores of lymphocyte-to-high-density lipoprotein cholesterol ratio (lymphocyte-to-HDL-c) may be a new indicator of inflammation and metabolic syndrome. Here, we investigated the associations of the lymphocyte-to-HDL-c with traditional and non-traditional cardiometabolic risk markers in subjects at high cardiovascular risk. This study is a cross-sectional analysis with subjects assisted in a Secondary Health Care (n = 581, age = 63.06 ± 13.86 years; 52.3% women). Lymphocyte-to-HDL-c ratio were assessed by routine laboratory tests. Anthropometric and/or biochemical variables were used to calculate traditional (body mass index - BMI, and waist-to-height ratio - WHtR) and non-traditional (lipid accumulation product index-LAP, visceral adiposity index-VAI, deep-abdominal-adipose-tissue index-DAAT, atherogenic index of plasma-AIP, and waist-hypertriglyceridemic phenotype-HTGW) cardiometabolic risk markers. Furthermore, anthropometric measurement waist circumference (WC), blood pressure, metabolic syndrome (MS), and biochemical markers (lipid and glycemic profile) were considered traditional markers of cardiometabolic risk. Pearson's chi-square test, Poisson regression with robust variance, or multinomial logistic regression were performed (α = 0.05). Individuals with a high lymphocyte-HDL-c ratio (> 0.84, 3rd tertile) were associated with the HTGW phenotype, high VAI, high LAP, hypertriglyceridemia, high AIP, high very low-density lipoprotein-cholesterol (VLDL-c), pre-diabetes, and 3 and 4 MS components compared with individuals in the first tertile, independent of confounders. Our findings supported the lymphocyte-to-HDL-c ratio as a potential biomarker during the screening of subjects at high cardiovascular risk.
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Affiliation(s)
- Flávia Galvão Cândido
- Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa-MG, 36570-900, Brazil
| | - Alessandra da Silva
- Laboratory of Health and Environment Education, Instituto Oswaldo Cruz, Av. Brasil, 4365, Manguinhos, 21040-360 Rio de Janeiro, Rio de Janeiro, Brazil
| | - Gilmara Alves Zanirate
- Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa-MG, 36570-900, Brazil
| | | | - Helen Hermana Miranda Hermsdorff
- Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa-MG, 36570-900, Brazil.
- Institute of Public Policies and Sustainable Development, Universidade Federal de Viçosa, Viçosa, 36570-900, Brazil.
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Zhou Y, Su X, Tan H, Xiao J. Association between metabolic score for visceral fat index and BMI-adjusted skeletal muscle mass index in American adults. Lipids Health Dis 2025; 24:29. [PMID: 39875924 PMCID: PMC11773733 DOI: 10.1186/s12944-025-02439-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/09/2024] [Accepted: 01/13/2025] [Indexed: 01/30/2025] Open
Abstract
BACKGROUND The metabolic score for visceral fat (METS-VF) is a recently identified index for evaluating visceral fat, also referred to as abdominal obesity. The skeletal muscle mass index (SMI) serves as a critical measure for assessing muscle mass and sarcopenia. Both obesity and the reduction of muscle mass can significantly affect human health. However, research exploring the relationship between METS-VF and SMI remains limited. This study aims to investigate whether a association exists between these two indices, and if so, to elucidate the nature of their interactions. METHODS We conducted a cross-sectional study using data from the NHANES database, focusing on U.S. adults aged 20 years and older from 2013 to 2018. Controlling for relevant covariables, we primarily investigated the association between METS-VF and SMI values utilizing weighted multivariable linear regression models. Additionally, we assessed the diagnostic efficacy of METS-VF for sarcopenia. RESULTS A total of 3,594 participants were included in this study for analysis. The final adjusted model from the weighted multivariable linear regression indicated that METS-VF was negatively associated with SMI, with a coefficient of β = -0.13 (95% CI: -0.14, -0.12; P < 0.001). Subgroup analyses further demonstrated that this negative association was consistent across different populations. Notably, the negative association varied significantly between diabetic and nondiabetic population, as well as among populations classified by different BMI categories. Additionally, threshold effect analysis identified a significant inflection knot at 6.33. The characteristic curves of the subjects' work illustrated that, compared to other indicators, METS-VF exhibited excellent diagnostic efficacy for sarcopenia, with an area under the curve (AUC) of 0.825. CONCLUSION Our results indicate that METS-VF is negatively correlated with SMI among adults in the United States, suggesting that visceral obesity exerts a detrimental effect on muscle mass. Furthermore, METS-VF shows potential as a valuable indicator for assessing SMI and sarcopenia. These findings underscore the importance of considering lipid metabolism disorders in the context of muscle health and highlight the potential for developing prevention strategies for sarcopenia.
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Affiliation(s)
- Yifan Zhou
- Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University, Changsha, 410003, People's Republic of China
| | - Xiangjie Su
- Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University, Changsha, 410003, People's Republic of China
| | - Haitao Tan
- Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University, Changsha, 410003, People's Republic of China.
| | - Jun Xiao
- Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University, Changsha, 410003, People's Republic of China.
- The No. 924 Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army, Guilin, China.
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Guo W, Zhao S, Chang Q, Sun J, Fan Y, Liu J. Negative association between 15 obesity- and lipid-related indices and testosterone in adult males: a population based cross-sectional study. Lipids Health Dis 2025; 24:24. [PMID: 39863911 PMCID: PMC11762110 DOI: 10.1186/s12944-025-02436-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/23/2024] [Accepted: 01/11/2025] [Indexed: 01/27/2025] Open
Abstract
BACKGROUND An association exists between obesity and reduced testosterone levels in males. The propose of this research is to reveal the correlation between 15 indices linked to obesity and lipid levels with the concentration of serum testosterone, and incidence of testosterone deficiency (TD) among adult American men. METHODS The study utilized information gathered from the National Health and Nutrition Examination Survey (NHANES) carried out from 2011 to 2016. The condition known as TD is typically characterized by a total serum testosterone level that falls below 300 ng/dL. The analysis used weighted linear and logistic regression methods to announce the association between 15 obesity- and lipid-related factors and serum testosterone levels as well as TD. Subgroup analyses were further carried out to confirm and validate the findings. Additionally, restricted cubic spline plots were utilized to examine non-linear relationships. Receiver operating characteristic (ROC) curves were created for the 15 factors, and the area under the curves (AUC) was calculated to assess the efficacy of each factor in detecting TD. RESULTS Among a group of 3,540 adult males, it was observed that all 15 obesity- and lipid-related indices showed a negative relationship with testosterone concentration and a direct correlation with the presence of TD. After accounting for all covariates, the analysis revealed that individuals within the highest quartile (Q4) for metabolic score for visceral fat (METS-VF) had the excellent probability of developing TD (OR = 13.412, 95%CIs: 4.222, 42.262, P < 0.001). Additionally, a non-linear relationship was detected between the METS-VF with TD. Within the model that incorporated all adjustments, the triglyceride glucose-waist to height ratio (TyG-WHtR) has the best performance for predicting TD (Overall: AUC = 0.762, 95%CIs: 0.743, 0.782, cut-off = 5.186). CONCLUSION Elevated levels of these 15 markers were inversely related to testosterone levels and were indicative of an elevated risk of TD. Among all indices analyzed, TyG-WHtR demonstrated the highest predictive value. TRIAL REGISTRATION Not available.
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Affiliation(s)
- Wei Guo
- Department of Urology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road Jinan, Shandong, 250012, People's Republic of China
| | - Shuo Zhao
- Department of Urology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road Jinan, Shandong, 250012, People's Republic of China
| | - Qinzheng Chang
- Department of Urology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road Jinan, Shandong, 250012, People's Republic of China
| | - Jiajia Sun
- Department of Urology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road Jinan, Shandong, 250012, People's Republic of China
| | - Yidong Fan
- Department of Urology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road Jinan, Shandong, 250012, People's Republic of China.
| | - Jikai Liu
- Department of Urology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road Jinan, Shandong, 250012, People's Republic of China.
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Jiao M, Chen J, Wang X, Tao W, Feng Y, Yang H, Yang H, Zhao S, Yang Y, Li Y. Anthropometric and metabolic parameters associated with visceral fat in non-obese type 2 diabetes individuals. Diabetol Metab Syndr 2025; 17:28. [PMID: 39844248 PMCID: PMC11753141 DOI: 10.1186/s13098-025-01583-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/11/2024] [Accepted: 01/08/2025] [Indexed: 01/24/2025] Open
Abstract
BACKGROUND AND AIM Visceral fat (VF) was proved to be a more precise predictor of atherosclerotic cardiovascular disease (ASCVD) risk in individuals with type 2 diabetes mellitus (T2DM) than body mass index (BMI) itself. Even when the BMI was normal, visceral fat area (VFA) ≥ 90 cm² could raise the ten-year risk of developing ASCVD. Therefore, it was worth evaluating the association of influencing factors with high VF in non-obese T2DM individuals. METHODS This study enrolled 1,409 T2DM participants with T2DM, of whom 538 had a normal BMI. Based on VFA, these subjects were divided into two groups: VF (+) (VFA ≥ 90cm2) (n = 110) and VF (-) (VFA < 90cm2) (n = 428). The measurement of VFA was conducted using an Omron VF measuring device. Anthropometric and metabolic parameters were detected. Novel insulin resistance indices, such as lipid accumulation product (LAP) was calculated. Factors associated with VF were screened using univariate analysis, multifactorial binary logistic regression models and chi-squared automatic interaction detector decision tree model. RESULTS The VF (+) OB (-) (BMI ≤ 23.9 kg/m2) prevalence were 7.8% in T2DM subjects (n = 1,409) and 20.4% in T2DM subjects with normal BMI (n = 538), respectively. In T2DM subjects with normal BMI, the logistic regression model suggested that neck circumference (NC) had an odds ratio (OR) of 1.891 (95% CI: 1.165-3.069, P = 0.010). The OR for VF gradually increased from the 1st to the 4th in LAP quartile (P < 0.05). LAP emerged as the root node, followed by NC in the decision tree model. Receiver operating characteristic curve (ROC) analysis demonstrated that the area under the curve (AUC) for NC in predicting high VF levels was 0.640 for males and 0.682 for females. Optimal NC cut-off points were 37.75 cm for males and 34.75 cm for females, respectively. Additionally, the AUC values of LAP in predicting high VF levels were 0.745 for males and 0.772 for females, with optimal LAP cut-off points of 22.64 and 26.45 for males and females, respectively. CONCLUSION This study identified NC and LAP can be considered predictors of high VF in T2DM subjects with normal BMI.
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Affiliation(s)
- Ming Jiao
- Department of Endocrinology, The Second People's Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, 650021, China
- Kunming Medical University, Kunming, Yunnan, 650021, China
| | - Jiaoli Chen
- Department of Endocrinology, The Second People's Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, 650021, China
| | - Xiaoling Wang
- Department of Endocrinology, The Second People's Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, 650021, China
| | - Wenyu Tao
- Department of Endocrinology, The Second People's Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, 650021, China
| | - Yunhua Feng
- Department of Endocrinology, The Second People's Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, 650021, China
| | - Huijun Yang
- Department of Endocrinology, The Second People's Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, 650021, China
| | - Haiying Yang
- Department of Endocrinology, The Second People's Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, 650021, China
| | - Shanshan Zhao
- Department of Endocrinology, The Second People's Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, 650021, China
| | - Ying Yang
- Department of Endocrinology, The Second People's Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, 650021, China.
| | - Yiping Li
- Department of Endocrinology, The Second People's Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, 650021, China.
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Wang Y, Fu C, Jin H, Yang Y, Li X, Liu K. Lipid metabolism indicators provide tools for the diagnosis of non-alcoholic fatty liver disease: results of a nationwide survey. Front Endocrinol (Lausanne) 2025; 15:1468228. [PMID: 39897962 PMCID: PMC11781989 DOI: 10.3389/fendo.2024.1468228] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/21/2024] [Accepted: 12/20/2024] [Indexed: 02/04/2025] Open
Abstract
Background Cardiometabolic index (CMI), visceral adiposity index (VAI), and lipid accumulation product (LAP) are lipid-related parameters that reflect central obesity, which is closely associated with the development of non-alcoholic fatty liver disease (NAFLD). The aim of this study is to investigate the effectiveness of these lipid-related parameters in diagnosing NAFLD and to compare their predictive abilities. Methods This population-based study extracted datasets from the National Health and Nutrition Examination Survey (NHANES) 2017-2020. CMI, VAI, and LAP were included in the multivariate logistic model as both continuous and categorical variables to assess the relationship between different lipid-related parameters and NAFLD. To further elucidate this connection, we utilized restricted cubic splines and conducted subgroup analysis. Additionally, the receiver operating characteristics (ROC) curve was employed to evaluate the predictive effectiveness of CMI, VAI, and LAP for NAFLD. Results The study included 2,878 adults as the study population, of whom 1,263 participants were diagnosed with NAFLD. When lipid-related parameters were analyzed as continuous variables, they showed a positive correlation with NAFLD. The OR(95%CI) were 2.29(1.81,2.89) for CMI (per 1-unit), 1.40(1.28,1.52) for VAI (per 1-unit) and 1.15(1.11,1.20) for LAP (per 10-units). This correlation remains statistically significant when the lipid-related parameters are analyzed as categorical variables. In descending order of diagnostic capability for NAFLD, the AUC values are as follows: LAP (0.794), CMI (0.752), and VAI (0.719). Conclusion CMI, VAI, and LAP may be important clinical indicators for identifying NAFLD, with LAP demonstrating the best predictive ability among them.
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Affiliation(s)
- Yongxin Wang
- Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China
| | - Chang Fu
- Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China
| | - Hengwei Jin
- Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China
| | - Yibo Yang
- Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China
| | - Xiaocong Li
- Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China
- Clinical Trial Research Center, China-Japan Friendship Hospital, Beijing, China
| | - Kai Liu
- Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China
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Tokugawa T, Sawada A, Higasa S, Wakabayashi I. Associations Between Blood Hemoglobin Concentrations and Cardiometabolic Risk in Middle-Aged Women. WOMEN'S HEALTH REPORTS (NEW ROCHELLE, N.Y.) 2025; 6:80-89. [PMID: 39882139 PMCID: PMC11773170 DOI: 10.1089/whr.2024.0140] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Accepted: 09/30/2024] [Indexed: 01/31/2025]
Abstract
Objective Patients with polycythemia have a high risk of thrombo-atherosclerotic diseases. However, it remains to be clarified whether a high blood hemoglobin level is related to cardiometabolic risk in women. Methods The overall subjects were 18,410 middle-aged women who had received health checkup examinations at their workplaces. The subjects were divided into four groups of quartiles for hemoglobin levels. Cardiometabolic risk factors were compared in the four quartile groups. Individuals showing abnormally low hemoglobin levels (less than 11.0 g/dL) and/or having a history of therapy for anemia (n = 3,690) were excluded from the study. Results The prevalence of polycythemia (hemoglobin: higher than 16.0 g/dL) was 0.14%. Body mass index, waist-to-height ratio, blood pressure, triglycerides, LDL cholesterol, and hemoglobin A1c were significantly higher in the highest quartile group of hemoglobin than in the lowest quartile group and tended to be higher with an increase of the quartile. Odds ratios of the highest versus lowest quartile groups of hemoglobin were 2.64 (2.25-3.10) for high LDL cholesterol/HDL cholesterol ratio, 3.05 (2.69-3.46) for high lipid accumulation product, 2.26 (2.05-2.50) for high cardiometabolic index, and 3.71 (3.07-4.47) for metabolic syndrome. Conclusions Although the prevalence of polycythemia was very low, cardiometabolic risk was higher in those showing relatively high hemoglobin levels than in those with lower levels. Therefore, normal high blood hemoglobin is suggestive of increased cardiovascular risk in middle-aged women.
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Affiliation(s)
- Tazuko Tokugawa
- Department of Respiratory Medicine and Hematology, School of Medicine, Hyogo Medical University, Nishinomiya, Japan
| | - Akihiro Sawada
- Department of Respiratory Medicine and Hematology, School of Medicine, Hyogo Medical University, Nishinomiya, Japan
| | - Satoshi Higasa
- Department of Respiratory Medicine and Hematology, School of Medicine, Hyogo Medical University, Nishinomiya, Japan
| | - Ichiro Wakabayashi
- Department of Preventive Medicine, School of Medicine, Hyogo Medical University, Nishinomiya, Japan
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Xu N, Zou H, Xu H, Chen Y, Wen Q, Xing X, Wu S. Association between five novel anthropometric indices and erectile dysfunction in US adults from NHANES database. Sci Rep 2025; 15:1625. [PMID: 39794403 PMCID: PMC11723986 DOI: 10.1038/s41598-024-80878-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/08/2024] [Accepted: 11/22/2024] [Indexed: 01/13/2025] Open
Abstract
Erectile Dysfunction (ED) is the leading cause of sexual dysfunction affecting hundreds of millions of men worldwide, and has been described as an important public health problem. The association of five novel anthropometrics related to obesity, lipids and glucose with ED remains unclear. To investigate the association of lipid accumulation products index (LAP), triglyceride glucose index (TyG), waist triglyceride index (WTI), weight-adjusted-waist index (WWI) and a body shape index (ABSI) with ED. Cross-sectional data from the NHANES were used. Participants were adults aged 20-85 y from 2001 to 2004. The analysis of logistic regressions, smooth curve fitting, subgroup analyses and generalized addition model were performed to examine the relationship between five novel anthropometric indicators and the prevalence of ED. An overall 1413 adult men were included in the study. After adjusting for confounding factors, the results of multiple regression analysis showed, ED positively correlated with LAP(OR = 1.0031, P < 0.05), TyG(OR = 1.2981, P < 0.05), WTI(OR = 1.4220, P < 0.05), WWI(OR = 1.6043, P < 0.001), and ABSI(OR = 1.6211, P < 0.05). Smoothed curve fitting and subgroup analyses proved the stability of the relationship. This cross-sectional study showed a positive correlation between these five novel anthropometric indicators (LAP, TyG, WTI, WWI, ABSI) and ED. Further studies are needed to explore their association better and the underlying mechanisms.
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Affiliation(s)
- Ningning Xu
- Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Chancheng District, Foshan, Guangdong Province, China
| | - Haoxi Zou
- Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Chancheng District, Foshan, Guangdong Province, China
| | - Huanying Xu
- Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Chancheng District, Foshan, Guangdong Province, China
| | - Yanfen Chen
- Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Chancheng District, Foshan, Guangdong Province, China
| | - Qidan Wen
- Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Chancheng District, Foshan, Guangdong Province, China
| | - Xiaoyan Xing
- Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Chancheng District, Foshan, Guangdong Province, China
| | - Suzhen Wu
- TCM gynecology department, Foshan Fosun Chancheng Hospital, Chancheng District, Foshan, Guangdong Province, China.
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