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For: Garcia JM, Sharafkhaneh H, Hirshkowitz M, Elkhatib R, Sharafkhaneh A. Weight and metabolic effects of CPAP in obstructive sleep apnea patients with obesity. Respir Res 2011;12:80. [PMID: 21676224 PMCID: PMC3146428 DOI: 10.1186/1465-9921-12-80] [Citation(s) in RCA: 53] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/02/2010] [Accepted: 06/15/2011] [Indexed: 12/18/2022] Open

For:	Garcia JM, Sharafkhaneh H, Hirshkowitz M, Elkhatib R, Sharafkhaneh A. Weight and metabolic effects of CPAP in obstructive sleep apnea patients with obesity. Respir Res 2011;12:80. [PMID: 21676224 PMCID: PMC3146428 DOI: 10.1186/1465-9921-12-80] [Citation(s) in RCA: 53] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/02/2010] [Accepted: 06/15/2011] [Indexed: 12/18/2022] Open

Number

Cited by Other Article(s)

Wang M, Tang J, Pan Z, Jiang H, Hu D, Zhu B, Liang Z, Zhao X, Li Y. Prospective Single-Arm Study of Remifentanil-Propofol Anesthesia with Manual Right Hypochondrial Compression for Painless Gastroscopy in Obese Patients. Drug Des Devel Ther 2025;19:877-890. [PMID: 39959120 PMCID: PMC11829745 DOI: 10.2147/dddt.s498238] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/16/2024] [Accepted: 01/29/2025] [Indexed: 02/18/2025] Open

Abstract

Purpose

The provision of comfortable and safe environment for painless gastroscopy in obese patients is an urgent clinical problem. This study aimed to determine the efficacy and safety of the novel Li anesthetic protocol for obesity (LAPO) which included remifentanil-propofol regimen, manual right hypochondrial compression (MRHC), easy-to-create mask, and jaw thrust at preoperative painless gastroscopy in obese patients.

Patients and Methods

This prospective, single-center, single-arm trial recruited 106 participants underwent LAPO for gastroscopy. The primary outcome was the incidence of hypoxemia (peripheral oxygen saturation [SpO2]: 75% ≤ SpO2 <90%, for >10 s and ≤60 s). Second outcomes included severe hypoxemia, the lowest SpO2 (L-SpO2), duration of hypoxemia, and other events.

Results

The 98 obese patients under LAPO, the median body mass index (BMI) was 39.2 kg/m2 and the incidence of hypoxemia was 27.5%, while the conventional anesthetic protocol for obesity (CAPO) in the reference was 40.4% with BMI 31.4 kg/m2. With the increase of class of obesity, a significant rise in the incidence of hypoxemia was observed, from class I by 11.8%, to 15.1% in class II, and 41.7% in class III. Paired t test showed that the L-SpO2 was significantly higher than L-SpO2 in overnight polysomnography (Nadir SpO2) (92% vs 76%, P<0.001). Moreover, severe obstructive sleep apnea (OSA) was associated with a 4.019-fold higher risk of hypoxemia (Odds ratios [OR], 4.019; 95% confidence interval [CI], 1.184 to 14.610; P=0.028); diabetes was associated with a 4.790-fold higher risk of hypoxemia (OR, 4.790; 95% CI, 1.288 to 23.600; P=0.030).

Conclusion

Compared with CAPO, LAPO reduced the incidence of hypoxemia from 40.4% to 27.5%, so, LAPO was safe and effective for painless gastroscopy. The finding might provide some new schedules for anesthetic management in the absence of advanced airway support instruments.

Clinical Trial Registration

ChiCTR2300077889.

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Oki T, Kozu Y, Hoshi M, Itoda Y, Furusho N, Ozoe R, Jinno Y, Hirata A, Kurosawa Y, Yamada S, Fukuda A, Hikichi M, Shikano S, Sugaya K, Hiranuma H, Maruoka S, Gon Y. The Relationship between Leptin Levels and Continuous Positive Airway Pressure Treatment: A Cluster Analysis. Sleep Sci 2024;17:e143-e150. [PMID: 38846593 PMCID: PMC11152640 DOI: 10.1055/s-0043-1777779] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/14/2022] [Accepted: 08/14/2023] [Indexed: 06/09/2024] Open

Affiliation(s)

Takashi Oki Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Yutaka Kozu Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Mamiko Hoshi Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Yasunori Itoda Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Naho Furusho Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Ryosuke Ozoe Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Yusuke Jinno Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Akifumi Hirata Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Yusuke Kurosawa Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Shiho Yamada Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Asami Fukuda Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Mari Hikichi Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Sotaro Shikano Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Kenichi Sugaya Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Hisato Hiranuma Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Shuichiro Maruoka Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan
Yasuhiro Gon Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan

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Chang JL, Goldberg AN, Alt JA, Alzoubaidi M, Ashbrook L, Auckley D, Ayappa I, Bakhtiar H, Barrera JE, Bartley BL, Billings ME, Boon MS, Bosschieter P, Braverman I, Brodie K, Cabrera-Muffly C, Caesar R, Cahali MB, Cai Y, Cao M, Capasso R, Caples SM, Chahine LM, Chang CP, Chang KW, Chaudhary N, Cheong CSJ, Chowdhuri S, Cistulli PA, Claman D, Collen J, Coughlin KC, Creamer J, Davis EM, Dupuy-McCauley KL, Durr ML, Dutt M, Ali ME, Elkassabany NM, Epstein LJ, Fiala JA, Freedman N, Gill K, Boyd Gillespie M, Golisch L, Gooneratne N, Gottlieb DJ, Green KK, Gulati A, Gurubhagavatula I, Hayward N, Hoff PT, Hoffmann OM, Holfinger SJ, Hsia J, Huntley C, Huoh KC, Huyett P, Inala S, Ishman SL, Jella TK, Jobanputra AM, Johnson AP, Junna MR, Kado JT, Kaffenberger TM, Kapur VK, Kezirian EJ, Khan M, Kirsch DB, Kominsky A, Kryger M, Krystal AD, Kushida CA, Kuzniar TJ, Lam DJ, Lettieri CJ, Lim DC, Lin HC, Liu SY, MacKay SG, Magalang UJ, Malhotra A, Mansukhani MP, Maurer JT, May AM, Mitchell RB, Mokhlesi B, Mullins AE, Nada EM, Naik S, Nokes B, Olson MD, Pack AI, Pang EB, Pang KP, Patil SP, Van de Perck E, Piccirillo JF, Pien GW, Piper AJ, Plawecki A, Quigg M, Ravesloot MJ, Redline S, Rotenberg BW, Ryden A, Sarmiento KF, Sbeih F, Schell AE, Schmickl CN, Schotland HM, Schwab RJ, Seo J, Shah N, Shelgikar AV, Shochat I, Soose RJ, Steele TO, Stephens E, Stepnowsky C, Strohl KP, Sutherland K, Suurna MV, Thaler E, Thapa S, Vanderveken OM, de Vries N, Weaver EM, Weir ID, Wolfe LF, Tucker Woodson B, Won CH, Xu J, Yalamanchi P, Yaremchuk K, Yeghiazarians Y, Yu JL, Zeidler M, Rosen IM. International Consensus Statement on Obstructive Sleep Apnea. Int Forum Allergy Rhinol 2023;13:1061-1482. [PMID: 36068685 PMCID: PMC10359192 DOI: 10.1002/alr.23079] [Citation(s) in RCA: 108] [Impact Index Per Article: 54.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/12/2022] [Revised: 08/12/2022] [Accepted: 08/18/2022] [Indexed: 11/08/2022]

Affiliation(s)

Jolie L. Chang University of California, San Francisco, California, USA
Andrew N. Goldberg University of California, San Francisco, California, USA
Jeremiah A. Alt University of Utah, Salt Lake City, Utah, USA
Mohammed Alzoubaidi Northwestern University, Chicago, Illinois, USA
Liza Ashbrook University of California, San Francisco, California, USA
Dennis Auckley Case Western Reserve University, Cleveland, Ohio, USA
Indu Ayappa Icahn School of Medicine at Mount Sinai, New York, New York, USA
Hira Bakhtiar Norwalk Hospital, Norwalk, Connecticut, USA
José E. Barrera Uniformed Services University, Washington D.C., USA
Bethany L. Bartley Harvard Medical School, Boston, Massachusetts, USA
Martha E. Billings University of Washington, Seattle, Washington, USA
Maurits S. Boon Sidney Kimmel Medical Center at Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Pien Bosschieter Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands
Itzhak Braverman Hillel Yaffe Medical Center, Hadera Technion, Faculty of Medicine, Hadera, Israel
Kara Brodie University of California, San Francisco, California, USA
Cristina Cabrera-Muffly University of Colorado School of Medicine, Aurora, Colorado, USA
Ray Caesar Stone Oak Orthodontics, San Antonio, Texas, USA
Michel B. Cahali University of Sao Paulo, São Paulo, Brazil
Yi Cai University of California, San Francisco, California, USA
Michelle Cao Stanford University, Palo Alto, California, USA
Robson Capasso Stanford University, Palo Alto, California, USA
Sean M. Caples Mayo Clinic, Rochester, Minnesota, USA
Lana M. Chahine University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Corissa P. Chang University of Pennsylvania, Philadelphia, Pennsylvania, USA
Katherine W. Chang Washington University, St. Louis, Missouri, USA
Nilika Chaudhary Brigham and Women’s Hospital, Boston, MA, USA
Crystal S. J. Cheong National University Hospital, Singapore
Susmita Chowdhuri Wayne State University and John D. Dingell VA Medical Center, Detroit, Michigan, USA
Peter A. Cistulli Faculty of Medicine and Health, University of Sydney, Sydney, Australia
David Claman University of California, San Francisco, California, USA
Jacob Collen Uniformed Services University, Bethesda, Maryland, USA
Kevin C. Coughlin University of Tennessee, Memphis, Tennessee, USA
Jennifer Creamer Uniformed Services University, Bethesda, Maryland, USA
Eric M. Davis University of Virginia, Charlottesville, Virginia, USA
Kara L. Dupuy-McCauley Mayo Clinic, Rochester, Minnesota, USA
Megan L. Durr Kaiser Permanente, Oakland, California, USA
Mohan Dutt University of Michigan, Ann Arbor, Michigan, USA
Mazen El Ali University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Nabil M. Elkassabany University of Virginia, Charlottesville, Virginia, USA
Lawrence J. Epstein Harvard Medical School, Boston, Massachusetts, USA
Justin A. Fiala Northwestern University, Chicago, Illinois, USA
Neil Freedman University of Chicago, Chicago, Illinois, USA
Kirat Gill Stanford University, Palo Alto, California, USA
M. Boyd Gillespie University of Tennessee, Memphis, Tennessee, USA
Lea Golisch University Hospital Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
Nalaka Gooneratne University of Pennsylvania, Philadelphia, Pennsylvania, USA
Daniel J. Gottlieb Harvard Medical School, Boston, Massachusetts, USA
Katherine K. Green University of Colorado, Aurora, Colorado, USA
Arushi Gulati University of California, San Francisco, California, USA
Indira Gurubhagavatula University of Pennsylvania, Philadelphia, Pennsylvania, USA
Nathan Hayward Monash Health, Victoria, Australia
Paul T. Hoff University of Michigan, Ann Arbor, Michigan, USA
Oliver M.G. Hoffmann University Hospital Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
Steven J. Holfinger Ohio State University, Columbus, Ohio, USA
Jennifer Hsia University of Minnesota, Minneapolis, Minnesota, USA
Colin Huntley Sidney Kimmel Medical Center at Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Kevin C. Huoh University of California, Irvine, California, USA
Phillip Huyett Harvard Medical School, Boston, Massachusetts, USA
Sanjana Inala Icahn School of Medicine at Mount Sinai, New York, New York, USA
Stacey L. Ishman University of Cincinnati, Cincinnati, Ohio, USA
Tarun K. Jella Case Western Reserve University, Cleveland, Ohio, USA
Aesha M. Jobanputra Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Andrew P. Johnson University of Colorado School of Medicine, Aurora, Colorado, USA
Mithri R. Junna Mayo Clinic, Rochester, Minnesota, USA
Jenna T. Kado University of Toledo, Toledo, Ohio, USA
Thomas M. Kaffenberger University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Vishesh K. Kapur University of Washington, Seattle, Washington, USA
Eric J. Kezirian University of Southern California, Los Angeles, California, USA
Meena Khan Ohio State University, Columbus, Ohio, USA
Douglas B. Kirsch University of North Carolina School of Medicine, Charlotte
Alan Kominsky Cleveland Clinic Head and Neck Institute, Cleveland, Ohio, USA
Meir Kryger Yale School of Medicine, New Haven, Connecticut, USA
Andrew D. Krystal University of California, San Francisco, California, USA
Clete A. Kushida Stanford University, Palo Alto, California, USA
Thomas J. Kuzniar University of Chicago, Chicago, Illinois, USA
Derek J. Lam Oregon Health and Science University, Portland, Oregon, USA
Christopher J. Lettieri Uniformed Services University, Bethesda, Maryland, USA
Diane C. Lim University of Miami, Miami, Florida, USA
Hsin-Ching Lin Chang Gung University, Kaohsiung, Taiwan
Stanley Y.C. Liu Stanford University, Palo Alto, California, USA
Stuart G. MacKay University of Wollongong, Wollongong, Australia
Ulysses J. Magalang Ohio State University, Columbus, Ohio, USA
Atul Malhotra University of California, San Diego, California, USA
Meghna P. Mansukhani Mayo Clinic, Rochester, Minnesota, USA
Joachim T. Maurer University Hospital Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
Anna M. May Case Western Reserve University, Cleveland, Ohio, USA
Ron B. Mitchell University of Texas, Southwestern and Children’s Medical Center Dallas, Texas, USA
Babak Mokhlesi Rush University Medical Center, Chicago, IL, USA
Anna E. Mullins University of Chicago, Chicago, Illinois, USA
Eman M. Nada Stony Brook University, New York, New York, USA
Sreelatha Naik Geisinger Health System, Danville, California, USA
Brandon Nokes University of California, San Diego, California, USA
Michael D. Olson Mayo Clinic, Rochester, Minnesota, USA
Allan I. Pack University of Pennsylvania, Philadelphia, Pennsylvania, USA
Edward B. Pang University of Glasgow, Glasgow, UK
Kenny P. Pang Paragon Medical Centre, Singapore
Susheel P. Patil Case Western Reserve University, Cleveland, Ohio, USA
Eli Van de Perck University of Antwerp, Belgium
Jay F. Piccirillo Washington University, St. Louis, Missouri, USA
Grace W. Pien Johns Hopkins University, Baltimore, Maryland, USA
Amanda J. Piper University of Sydney, Sydney, Australia
Andrea Plawecki Henry Ford Health, Detroit, Michigan, USA
Mark Quigg University of Virginia, Charlottesville, Virginia, USA
Madeline J.L. Ravesloot OLVG, Amsterdam, The Netherlands
Susan Redline Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Brian W. Rotenberg Western University, Ontario, Canada
Armand Ryden Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA
Kathleen F. Sarmiento University of California, San Francisco, California, USA
Firas Sbeih Cleveland Clinic Head and Neck Institute, Cleveland, Ohio, USA
Amy E. Schell University of Colorado, Aurora, Colorado, USA
Christopher N. Schmickl University of California, San Diego, California, USA
Helena M. Schotland Icahn School of Medicine at Mount Sinai, New York, New York, USA
Richard J. Schwab University of Pennsylvania, Philadelphia, Pennsylvania, USA
Jiyeon Seo University of California, Los Angeles, California, USA
Neomi Shah Icahn School of Medicine at Mount Sinai, New York, New York, USA
Anita Valanju Shelgikar University of Michigan, Ann Arbor, Michigan, USA
Isaac Shochat Hillel Yaffe Medical Center, Hadera, Israel
Ryan J. Soose University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Toby O. Steele University of California, Davis, California, USA
Erika Stephens University of California, San Francisco, California, USA
Carl Stepnowsky University of California, San Diego, California, USA
Kingman P. Strohl Case Western Reserve University, Cleveland, Ohio, USA
Kate Sutherland University of Sydney, Sydney, Australia
Maria V. Suurna Weill Cornell Medicine, New York, New York, USA
Erica Thaler University of Pennsylvania, Philadelphia, Pennsylvania, USA
Sritika Thapa Yale School of Medicine, New Haven, Connecticut, USA
Olivier M. Vanderveken University of Antwerp, Belgium
Nico de Vries Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands
Edward M. Weaver University of Washington, Seattle, Washington, USA
Ian D. Weir Yale School of Medicine, New Haven, Connecticut, USA
Lisa F. Wolfe Northwestern University, Chicago, Illinois, USA
B. Tucker Woodson Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Christine H.J. Won Yale School of Medicine, New Haven, Connecticut, USA
Josie Xu University of Toronto, Ontario, Canada
Pratyusha Yalamanchi University of Michigan, Ann Arbor, Michigan, USA
Kathleen Yaremchuk Henry Ford Health, Detroit, Michigan, USA
Yerem Yeghiazarians University of California, San Francisco, California, USA
Jason L. Yu Emory University, Georgia, USA
Michelle Zeidler University of California, Los Angeles, California, USA
Ilene M. Rosen University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Michaelidou M, Pappachan JM, Jeeyavudeen MS. Management of diabesity: Current concepts. World J Diabetes 2023;14:396-411. [PMID: 37122433 PMCID: PMC10130896 DOI: 10.4239/wjd.v14.i4.396] [Citation(s) in RCA: 36] [Impact Index Per Article: 18.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/25/2022] [Revised: 01/15/2023] [Accepted: 03/20/2023] [Indexed: 04/12/2023] Open

Dupuy-McCauley K, Benzo R, Barwise A. Designing a program to support weight loss for patients attending the sleep medicine clinic: a qualitative study. J Clin Sleep Med 2023;19:459-471. [PMID: 36458729 PMCID: PMC9978432 DOI: 10.5664/jcsm.10354] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/18/2022] [Revised: 10/21/2022] [Accepted: 10/21/2022] [Indexed: 12/04/2022]

Relationships of orexigenic and anorexigenic hormones with body fat distribution in patients with obstructive sleep apnea syndrome. Eur Arch Otorhinolaryngol 2022;280:2445-2452. [PMID: 36547712 DOI: 10.1007/s00405-022-07799-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/24/2022] [Accepted: 12/14/2022] [Indexed: 12/24/2022]

Wang Y, Hu C. Leptin and Asthma: What Are the Interactive Correlations? Biomolecules 2022;12:biom12121780. [PMID: 36551211 PMCID: PMC9775505 DOI: 10.3390/biom12121780] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/25/2022] [Revised: 11/25/2022] [Accepted: 11/28/2022] [Indexed: 12/02/2022] Open

L-Citrulline Supplementation Reduces Blood Pressure and Myocardial Infarct Size under Chronic Intermittent Hypoxia, a Major Feature of Sleep Apnea Syndrome. Antioxidants (Basel) 2022;11:antiox11122326. [PMID: 36552534 PMCID: PMC9774116 DOI: 10.3390/antiox11122326] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/10/2022] [Revised: 11/14/2022] [Accepted: 11/17/2022] [Indexed: 11/25/2022] Open

Obesity as a mediator linking sleep-disordered breathing to both impaired fasting glucose and type 2 diabetes. Sleep Breath 2022;27:1067-1080. [DOI: 10.1007/s11325-022-02705-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/12/2022] [Revised: 08/24/2022] [Accepted: 08/30/2022] [Indexed: 10/14/2022]

Pardak P, Filip R, Woliński J. The Impact of Sleep-Disordered Breathing on Ghrelin, Obestatin, and Leptin Profiles in Patients with Obesity or Overweight. J Clin Med 2022;11:jcm11072032. [PMID: 35407646 PMCID: PMC8999926 DOI: 10.3390/jcm11072032] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/10/2022] [Revised: 03/30/2022] [Accepted: 04/02/2022] [Indexed: 12/26/2022] Open

Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux. J Clin Med 2021;10:jcm10215195. [PMID: 34768715 PMCID: PMC8584398 DOI: 10.3390/jcm10215195] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/21/2021] [Revised: 10/31/2021] [Accepted: 11/04/2021] [Indexed: 12/16/2022] Open

Brown LK. Up, down, or no change: weight gain as an unwanted side effect of CPAP for obstructive sleep apnea. J Clin Sleep Med 2021;16:21-22. [PMID: 33054961 DOI: 10.5664/jcsm.8888] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/13/2022]

Lin J, Jiang Y, Wang G, Meng M, Zhu Q, Mei H, Liu S, Jiang F. Associations of short sleep duration with appetite-regulating hormones and adipokines: A systematic review and meta-analysis. Obes Rev 2020;21:e13051. [PMID: 32537891 DOI: 10.1111/obr.13051] [Citation(s) in RCA: 55] [Impact Index Per Article: 11.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/28/2020] [Revised: 05/07/2020] [Accepted: 05/07/2020] [Indexed: 12/12/2022]

Affiliation(s)

Jianfei Lin Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Yanrui Jiang Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Guanghai Wang Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Min Meng Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Qi Zhu Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Hao Mei Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,Department of Data Science, School of Population Health, University of Mississippi Medical Center, Jackson, Mississippi, USA
Shijian Liu Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Fan Jiang Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.,MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Pleava R, Mihaicuta S, Serban CL, Ardelean C, Marincu I, Gaita D, Frent S. Long-Term Effects of Continuous Positive Airway Pressure (CPAP) Therapy on Obesity and Cardiovascular Comorbidities in Patients with Obstructive Sleep Apnea and Resistant Hypertension-An Observational Study. J Clin Med 2020;9:jcm9092802. [PMID: 32872644 PMCID: PMC7564990 DOI: 10.3390/jcm9092802] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/03/2020] [Revised: 08/23/2020] [Accepted: 08/28/2020] [Indexed: 12/15/2022] Open

Tserenpil G, Gebre M, Zergham AS, Sekhon AK, Malik BH. Managements for Obstructive Sleep Apnea in Adults: Review. Cureus 2020;12:e9905. [PMID: 32968568 PMCID: PMC7505527 DOI: 10.7759/cureus.9905] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/06/2020] [Accepted: 08/20/2020] [Indexed: 11/11/2022] Open

Dinh-Thi-Dieu H, Vo-Thi-Kim A, Tran-Van H, Duong-Quy S. Efficacy and adherence of auto-CPAP therapy in patients with obstructive sleep apnea: a prospective study. Multidiscip Respir Med 2020;15:468. [PMID: 32153777 PMCID: PMC7037646 DOI: 10.4081/mrm.2020.468] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/07/2020] [Accepted: 01/08/2020] [Indexed: 01/26/2023] Open

Aro M, Anttalainen U, Kurki S, Irjala K, Polo O, Saaresranta T. Gender-specific change in leptin concentrations during long-term CPAP therapy. Sleep Breath 2019;24:191-199. [PMID: 31055727 PMCID: PMC7128000 DOI: 10.1007/s11325-019-01846-y] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/30/2018] [Revised: 01/17/2019] [Accepted: 04/15/2019] [Indexed: 12/27/2022]

Abstract

Purpose

Nasal continuous positive airway pressure (CPAP) alleviates sleepiness in patients with obstructive sleep apnoea syndrome (OSAS), but part of OSAS patients keep gaining weight. Leptin and insulin-like growth factor-1 (IGF-1) interact with energy balance, and CPAP therapy has been suggested to influence these endocrine factors. We hypothesised that leptin would decrease during long-term CPAP therapy, and weight gain would associate with OSAS severity, lower CPAP adherence, lower IGF-1, and leptin concentrations.

Methods

Consecutive patients (n = 223) referred to sleep study with suspected OSAS were enrolled. Patients underwent cardiorespiratory polygraphy at baseline. Questionnaires were completed, and blood samples were drawn both at baseline and after 3 years. A total of 149 (67%; M 65, F 84) patients completed the follow-up. Plasma samples were available from 114 patients, 109 of which with CPAP adherence data (49 CPAP users, 60 non-users).

Results

At baseline, the CPAP users were more obese and had more severe OSAS than the non-users. Leptin concentrations did not differ. After follow-up, leptin concentrations were higher in CPAP users (30.2 ng/ml vs. 16.8 ng/ml; p = 0.001). In regression analysis, increase in leptin concentrations was independent of age, baseline body mass index (BMI), or the change in BMI. Leptin concentrations increased among females (− 8.9 vs. 12.7 ng/ml; p < 0.001); whereas in men, CPAP did not have an effect, if not opposed the natural decrease in leptin observed in men not using CPAP. Change in IGF-1 levels did not differ.

Conclusions

Our results suggest increase in leptin concentrations during long-term CPAP therapy among females.

Electronic supplementary material

The online version of this article (10.1007/s11325-019-01846-y) contains supplementary material, which is available to authorized users.

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Weighing the Impact of CPAP Therapy on Body Mass in Persons With OSA. Chest 2019;155:657-658. [DOI: 10.1016/j.chest.2018.10.029] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/03/2018] [Accepted: 10/03/2018] [Indexed: 11/26/2022] Open

Hoyos CM, Murugan SM, Melehan KL, Yee BJ, Phillips CL, Killick R, Cayanan EA, Wong KK, Liu PY, Grunstein RR, Marshall NS. Dose-dependent effects of continuous positive airway pressure for sleep apnea on weight or metabolic function: Individual patient-level clinical trial meta-analysis. J Sleep Res 2018;28:e12788. [PMID: 30450787 DOI: 10.1111/jsr.12788] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/24/2018] [Revised: 09/18/2018] [Accepted: 10/09/2018] [Indexed: 12/14/2022]

Affiliation(s)

Camilla M Hoyos Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.,Healthy Brain Ageing Program, Brain and Mind Centre, Charles Perkins Centre, School of Psychology, University of Sydney, Sydney, New South Wales, Australia
Swati M Murugan Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.,Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
Kerri L Melehan Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.,Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.,Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Brendon J Yee Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.,Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.,Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Craig L Phillips Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.,Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia
Roo Killick Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
Elizabeth A Cayanan Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.,Sydney Nursing School, University of Sydney, Sydney, New South Wales, Australia
Keith K Wong Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.,Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.,Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Peter Y Liu Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Los Angeles, California, USA
Ronald R Grunstein Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.,Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
Nathaniel S Marshall Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.,Sydney Nursing School, University of Sydney, Sydney, New South Wales, Australia

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Muraki I, Wada H, Tanigawa T. Sleep apnea and type 2 diabetes. J Diabetes Investig 2018;9:991-997. [PMID: 29453905 PMCID: PMC6123041 DOI: 10.1111/jdi.12823] [Citation(s) in RCA: 81] [Impact Index Per Article: 11.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/07/2017] [Revised: 02/05/2018] [Accepted: 02/08/2018] [Indexed: 02/02/2023] Open

Role of Leptin in Obstructive Sleep Apnea. Ann Am Thorac Soc 2018;14:1607-1621. [PMID: 28796527 DOI: 10.1513/annalsats.201702-181fr] [Citation(s) in RCA: 28] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/27/2022] Open

Basoglu OK, Zou D, Tasbakan MS, Hedner J, Ryan S, Verbraecken J, Escourrou P, Antalainen U, Kvamme JA, Bonsignore MR, Schiza S, Grote L. Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort. J Sleep Res 2018;27:e12705. [DOI: 10.1111/jsr.12705] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/22/2017] [Revised: 02/28/2018] [Accepted: 04/02/2018] [Indexed: 12/21/2022]

Tachikawa R, Ikeda K, Minami T, Matsumoto T, Hamada S, Murase K, Tanizawa K, Inouchi M, Oga T, Akamizu T, Mishima M, Chin K. Changes in Energy Metabolism after Continuous Positive Airway Pressure for Obstructive Sleep Apnea. Am J Respir Crit Care Med 2017;194:729-38. [PMID: 26930227 DOI: 10.1164/rccm.201511-2314oc] [Citation(s) in RCA: 72] [Impact Index Per Article: 9.0] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/14/2022] Open

Abstract

RATIONALE

Disrupted energy homeostasis in obstructive sleep apnea (OSA) may lead to weight gain. Paradoxically, treating OSA with continuous positive airway pressure (CPAP) may also promote weight gain, although the underlying mechanism remains unclear.

OBJECTIVES

To explore the underlying mechanism by which patients with OSA gain weight after CPAP.

METHODS

A comprehensive assessment of energy metabolism was performed in 63 newly diagnosed OSA study participants (51 men; 60.8 ± 10.1 yr; apnea-hypopnea index >20 h(-1)) at baseline, CPAP initiation, and at a 3-month follow-up. Measurements included polysomnography, body weight, body composition, basal metabolic rate (BMR), hormones (norepinephrine, cortisol, leptin, ghrelin, insulin-like growth factor-1), dietary intake, eating behavior, and physical activity.

MEASUREMENTS AND MAIN RESULTS

BMR significantly decreased after CPAP (1,584 kcal/d at baseline, 1,561 kcal/d at CPAP initiation, and 1,508 kcal/d at follow-up; P < 0.001), whereas physical activity and total caloric intake did not significantly change. In multivariate regression, baseline apnea-hypopnea index, Δurine norepinephrine, and CPAP adherence were significant predictors of ΔBMR. The weight gainers had higher leptin levels, lower ghrelin levels, and higher eating behavior scores than the non-weight gainers, indicating a positive energy balance and disordered eating behavior among the weight gainers. Among the parameters related to energy metabolism, increased caloric intake was a particularly significant predictor of weight gain.

CONCLUSIONS

Although a reduction in BMR after CPAP predisposes to a positive energy balance, dietary intake and eating behavior had greater impacts on weight change. These findings highlight the importance of lifestyle modifications combined with CPAP. Clinical trial registered with http://www.umin.ac.jp/english/ (UMIN000012639).

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Chen L, Kuang J, Pei JH, Chen HM, Chen Z, Li ZW, Yang HZ, Fu XY, Wang L, Chen ZJ, Lai SQ, Zhang ST. Continuous positive airway pressure and diabetes risk in sleep apnea patients: A systemic review and meta-analysis. Eur J Intern Med 2017;39:39-50. [PMID: 27914881 DOI: 10.1016/j.ejim.2016.11.010] [Citation(s) in RCA: 36] [Impact Index Per Article: 4.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/20/2016] [Revised: 11/16/2016] [Accepted: 11/20/2016] [Indexed: 12/16/2022]

Enhanced recovery after bariatric surgery. Curr Opin Anaesthesiol 2017;30:133-139. [DOI: 10.1097/aco.0000000000000404] [Citation(s) in RCA: 23] [Impact Index Per Article: 2.9] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/10/2023]

Shechter A, Kovtun K, St-Onge MP. Effects of continuous positive airway pressure on energy intake in obstructive sleep apnea: A pilot sham-controlled study. Physiol Behav 2016;167:399-403. [PMID: 27769851 DOI: 10.1016/j.physbeh.2016.10.011] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/24/2016] [Revised: 07/29/2016] [Accepted: 10/15/2016] [Indexed: 10/20/2022]

Shechter A. Effects of continuous positive airway pressure on energy balance regulation: a systematic review. Eur Respir J 2016;48:1640-1657. [PMID: 27824596 PMCID: PMC5201109 DOI: 10.1183/13993003.00689-2016] [Citation(s) in RCA: 24] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/05/2016] [Accepted: 08/12/2016] [Indexed: 11/05/2022]

Turnbull CD, Rossi VA, Santer P, Schwarz EI, Stradling JR, Petousi N, Kohler M. Effect of OSA on hypoxic and inflammatory markers during CPAP withdrawal: Further evidence from three randomized control trials. Respirology 2016;22:793-799. [PMID: 27860068 DOI: 10.1111/resp.12946] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/20/2016] [Revised: 09/08/2016] [Accepted: 09/08/2016] [Indexed: 12/19/2022]

Koren D, Dumin M, Gozal D. Role of sleep quality in the metabolic syndrome. Diabetes Metab Syndr Obes 2016;9:281-310. [PMID: 27601926 PMCID: PMC5003523 DOI: 10.2147/dmso.s95120] [Citation(s) in RCA: 116] [Impact Index Per Article: 12.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 01/19/2023] Open

Myllylä M, Kurki S, Anttalainen U, Saaresranta T, Laitinen T. High Adherence to CPAP Treatment Does Not Prevent the Continuation of Weight Gain among Severely Obese OSAS Patients. J Clin Sleep Med 2016;12:519-28. [PMID: 26888588 DOI: 10.5664/jcsm.5680] [Citation(s) in RCA: 13] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/28/2015] [Accepted: 10/29/2015] [Indexed: 11/13/2022]

No elevation of serum adiponectin in OSA patients after continuous positive airway pressure treatment: a meta-analysis. Sleep Biol Rhythms 2016. [DOI: 10.1007/s41105-016-0057-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/22/2022]

Martínez-Ceron E, Fernández-Navarro I, Garcia-Rio F. Effects of continuous positive airway pressure treatment on glucose metabolism in patients with obstructive sleep apnea. Sleep Med Rev 2016;25:121-30. [DOI: 10.1016/j.smrv.2015.03.002] [Citation(s) in RCA: 49] [Impact Index Per Article: 5.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/28/2015] [Revised: 03/09/2015] [Accepted: 03/23/2015] [Indexed: 12/20/2022]

Association between continuous positive airway pressure and circulating omentin levels in patients with obstructive sleep apnoea. Sleep Breath 2016;20:939-45. [DOI: 10.1007/s11325-016-1315-2] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/09/2015] [Revised: 12/21/2015] [Accepted: 01/11/2016] [Indexed: 10/22/2022]

Impact of Continuous Positive Airway Pressure on Cardiovascular Risk Factors in High-Risk Patients. Curr Atheroscler Rep 2015;17:62. [DOI: 10.1007/s11883-015-0540-7] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/23/2022]

Chen LD, Liu JN, Lin L, Wu Z, Li H, Ye YM, Xu QZ, Lin QC. Effect of Continuous Positive Airway Pressure on Adiponectin in Patients with Obstructive Sleep Apnea: A Meta-Analysis. PLoS One 2015;10:e0136837. [PMID: 26367527 PMCID: PMC4569056 DOI: 10.1371/journal.pone.0136837] [Citation(s) in RCA: 9] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/20/2015] [Accepted: 08/10/2015] [Indexed: 11/30/2022] Open

Affiliation(s)

Li-Da Chen Department of Respiratory Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, No 59, Shenglixi road, Xiangcheng district, Zhangzhou, Fujian province, People's Republic of China, 363000
Jian-Nan Liu Department of Respiratory Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, No 59, Shenglixi road, Xiangcheng district, Zhangzhou, Fujian province, People's Republic of China, 363000
Li Lin Department of Respiratory Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, No 59, Shenglixi road, Xiangcheng district, Zhangzhou, Fujian province, People's Republic of China, 363000
Zhi Wu Department of Respiratory Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, No 59, Shenglixi road, Xiangcheng district, Zhangzhou, Fujian province, People's Republic of China, 363000
Hao Li Department of Respiratory Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, No 59, Shenglixi road, Xiangcheng district, Zhangzhou, Fujian province, People's Republic of China, 363000
Yu-Ming Ye Department of Respiratory Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, No 59, Shenglixi road, Xiangcheng district, Zhangzhou, Fujian province, People's Republic of China, 363000
Qiao-Zhen Xu Department of Respiratory Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, No 59, Shenglixi road, Xiangcheng district, Zhangzhou, Fujian province, People's Republic of China, 363000
Qi-Chang Lin Fujian Provincial Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease of the Fujian Medical University, Department of Respiratory Medicine, the First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong road, Taijiang district, Fuzhou, Fujian Province, People's Republic of China, 350005 * E-mail:

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Chihara Y, Akamizu T, Azuma M, Murase K, Harada Y, Tanizawa K, Handa T, Oga T, Mishima M, Chin K. Among Metabolic Factors, Significance of Fasting and Postprandial Increases in Acyl and Desacyl Ghrelin and the Acyl/Desacyl Ratio in Obstructive Sleep Apnea before and after Treatment. J Clin Sleep Med 2015;11:895-905. [PMID: 25845896 PMCID: PMC4513267 DOI: 10.5664/jcsm.4942] [Citation(s) in RCA: 16] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/25/2014] [Accepted: 03/03/2015] [Indexed: 12/23/2022]

Abstract

STUDY OBJECTIVES

There are reports suggesting that obstructive sleep apnea (OSA) may itself cause weight gain. However, recent reports showed increases in body mass index (BMI) following continuous positive airway pressure (CPAP) treatments. When considering weight changes, changes in humoral factors that have significant effects on appetite such as acyl (AG) and desacyl ghrelin (DAG), leptin, insulin, and glucose and their interactions, examples of which are AG/DAG and AG/insulin, are important. The aim of this study was to test the hypothesis that some appetite-related factors had a specific profile before and after CPAP treatment.

METHODS

Metabolic parameters were measured cross-sectionally while fasting and 30, 60, 90, and 120 min following breakfast in no or mild OSA (apnea-hypopnea index < 15, n = 15) and moderate-to-severe OSA (apnea-hypopnea index ≥ 15, n = 39) participants in a single institute. There were no differences in age, sex, BMI, or visceral fat accumulation between the two groups. Twenty-one patients with moderate-to-severe OSA who received CPAP treatment also prospectively underwent the same testing following 3 months of CPAP treatment.

RESULTS

Although fasting and postprandial glucose, insulin, and leptin levels did not differ between no or mild OSA and moderate-to-severe OSA participants, AG and DAG, including AG/DAG and AG/insulin, under fasting and postprandial conditions were significantly increased in the moderate-to-severe OSA patients (p < 0.01). After 3 months of CPAP treatment in 21 of the moderate-to-severe OSA participants, AG/DAG did not change significantly, but other ghrelin-related parameters including AG/insulin significantly decreased compared with values before treatment but remained higher than in no or mild OSA.

CONCLUSION

Among several important metabolic factors, ghrelin-related factors had the strongest associations with moderate-to-severe OSA. These results indicate that continuous changes in ghrelin secretion in OSA patients existed at least within 3 months of CPAP treatment. Methods to prevent OSA as well as treatment in its early stage may be recommended.

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Azzam H, Malnick S. Non-alcoholic fatty liver disease - the heart of the matter. World J Hepatol 2015;7:1369-1376. [PMID: 26052382 PMCID: PMC4450200 DOI: 10.4254/wjh.v7.i10.1369] [Citation(s) in RCA: 36] [Impact Index Per Article: 3.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/21/2014] [Revised: 03/02/2015] [Accepted: 04/02/2015] [Indexed: 02/06/2023] Open

Lam DCL, Lam KSL, Ip MSM. Obstructive sleep apnoea, insulin resistance and adipocytokines. Clin Endocrinol (Oxf) 2015;82:165-77. [PMID: 25154902 DOI: 10.1111/cen.12597] [Citation(s) in RCA: 21] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/30/2014] [Revised: 05/24/2014] [Accepted: 08/18/2014] [Indexed: 12/17/2022]

Chen X, Niu X, Xiao Y, Dong J, Lu M, Kong W. Effect of continuous positive airway pressure on leptin levels in patients with obstructive sleep apnea: a meta-analysis. Otolaryngol Head Neck Surg 2014;152:610-8. [PMID: 25527507 DOI: 10.1177/0194599814562719] [Citation(s) in RCA: 22] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/17/2014] [Accepted: 11/14/2014] [Indexed: 11/15/2022]

Biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome: current status and future perspectives. Pulm Med 2014;2014:930535. [PMID: 25538852 PMCID: PMC4265695 DOI: 10.1155/2014/930535] [Citation(s) in RCA: 33] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/30/2014] [Accepted: 10/23/2014] [Indexed: 02/06/2023] Open

Nicholl DDM, Hanly PJ, Poulin MJ, Handley GB, Hemmelgarn BR, Sola DY, Ahmed SB. Evaluation of continuous positive airway pressure therapy on renin-angiotensin system activity in obstructive sleep apnea. Am J Respir Crit Care Med 2014;190:572-80. [PMID: 25033250 DOI: 10.1164/rccm.201403-0526oc] [Citation(s) in RCA: 86] [Impact Index Per Article: 7.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/13/2023] Open

Abstract

RATIONALE

Obstructive sleep apnea (OSA) has been associated with kidney function loss, which may be related to changes in the renin-angiotensin system (RAS).

OBJECTIVES

We sought to determine the effect of continuous positive airway pressure (CPAP) of patients with OSA on renal hemodynamics at baseline and in response to angiotensin II (AngII), which reflects RAS activity.

METHODS

Twenty normotensive, nondiabetic, newly diagnosed OSA subjects (15 men, 5 women, 50 ± 2 yr, respiratory disturbance index [RDI] > 15 h(-1)) with nocturnal hypoxemia (SaO2 < 90% for >12% of the night) were studied in high-salt balance pre- and post-CPAP therapy (>4 h CPAP use/night for 1 mo). Glomerular filtration rate (GFR), renal plasma flow (RPF), and filtration fraction (FF) (a surrogate marker for intraglomerular pressure) were measured pre- and post-CPAP using inulin and para-aminohippurate clearance techniques at baseline and in response to graded AngII infusion (3 ng/kg/min × 30 min and 6 ng/kg/min × 30 min, respectively).

MEASUREMENTS AND MAIN RESULTS

CPAP corrected OSA and hypoxemia (RDI: 42 ± 4 vs. 4 ± 1 h(-1), P < 0.001; duration SaO2 < 90%: 36% ± 5% vs. 6 ± 2%, P < 0.001). CPAP reduced GFR (124 ± 8 ml/min vs. 110 ± 6 ml/min, P = 0.014), increased RPF (692 ± 36 ml/min vs. 749 ± 40 ml/min, P = 0.059), and reduced baseline FF (18.9 ± 1.6% vs. 15.3 ± 1.0%, P = 0.004). Post-CPAP demonstrated a blunted GFR response (-9 ± 3 ml/min vs. -2 ± 2 ml/min, P = 0.033) and augmented RPF response (-182 ± 22 ml/min vs. -219 ± 25 ml/min, P = 0.024) to AngII. FF response was maintained (P = 0.4). CPAP reduced baseline mean arterial pressure (94 ± 2 vs. 89 ± 2 mm Hg, P = 0.002), plasma aldosterone (149 ± 18 vs. 109 ± 10 pmol/L, P = 0.003), and urinary protein excretion (61 [39-341] mg/day vs. 56 [22-204] mg/d, P = 0.003).

CONCLUSIONS

CPAP therapy was associated with improved renal hemodynamics and down-regulation of renal RAS activity, suggesting a potential therapeutic benefit for kidney function.

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Schlatzer C, Schwarz EI, Kohler M. The effect of continuous positive airway pressure on metabolic variables in patients with obstructive sleep apnoea. Chron Respir Dis 2014;11:41-52. [PMID: 24431410 DOI: 10.1177/1479972313516882] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/25/2022] Open

Batool-Anwar S, Goodwin JL, Drescher AA, Baldwin CM, Simon RD, Smith TW, Quan SF. Impact of CPAP on activity patterns and diet in patients with obstructive sleep apnea (OSA). J Clin Sleep Med 2014;10:465-72. [PMID: 24910546 DOI: 10.5664/jcsm.3686] [Citation(s) in RCA: 29] [Impact Index Per Article: 2.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/13/2022]

Abstract

STUDY OBJECTIVES

Patients with severe OSA consume greater amounts of cholesterol, protein, and fat as well as have greater caloric expenditure. However, it is not known whether their activity levels or diet change after treatment with CPAP. To investigate this issue, serial assessments of activity and dietary intake were performed in the Apnea Positive Pressure Long-term Efficacy Study (APPLES); a 6-month randomized controlled study of CPAP vs. sham CPAP on neurocognitive outcomes.

METHODS

Subjects were recruited into APPLES at 5 sites through clinic encounters or public advertisement. After undergoing a diagnostic polysomnogram, subjects were randomized to CPAP or sham if their AHI was ≥ 10. Adherence was assessed using data cards from the devices. At the Tucson and Walla Walla sites, subjects were asked to complete validated activity and food frequency questionnaires at baseline and their 4-month visit.

RESULTS

Activity and diet data were available at baseline and after 4 months treatment with CPAP or sham in up to 231 subjects (117 CPAP, 114 Sham). Mean age, AHI, BMI, and Epworth Sleepiness Score (ESS) for this cohort were 55 ± 13 [SD] years, 44 ± 27 /h, 33 ± 7.8 kg/m(2), and 10 ± 4, respectively. The participants lacking activity and diet data were younger, had lower AHI and arousal index, and had better sleep efficiency (p < 0.05). The BMI was higher among women in both CPAP and Sham groups. However, compared to women, men had higher AHI only in the CPAP group (50 vs. 34). Similarly, the arousal index was higher among men in CPAP group. Level of adherence defined as hours of device usage per night at 4 months was significantly higher among men in CPAP group (4.0 ± 2.9 vs. 2.6 ± 2.6). No changes in consumption of total calories, protein, carbohydrate or fat were noted after 4 months. Except for a modest increase in recreational activity in women (268 ± 85 vs. 170 ± 47 calories, p < 0.05), there also were no changes in activity patterns.

CONCLUSION

Except for a modest increase in recreational activity in women, OSA patients treated with CPAP do not substantially change their diet or physical activity habits after treatment. .

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Gallegos L, Dharia T, Gadegbeku AB. Effect of continuous positive airway pressure on type 2 diabetes mellitus and glucose metabolism. Hosp Pract (1995) 2014;42:31-37. [PMID: 24769782 DOI: 10.3810/hp.2014.04.1101] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 06/03/2023]

Association between continuous positive airway pressure and changes in serum leptin in patients with obstructive sleep apnoea: a meta-analysis. Sleep Breath 2014;18:695-702. [PMID: 24504750 DOI: 10.1007/s11325-014-0941-9] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/07/2013] [Revised: 12/01/2013] [Accepted: 01/13/2014] [Indexed: 01/06/2023]

Quan SF, Budhiraja R, Clarke DP, Goodwin JL, Gottlieb DJ, Nichols DA, Simon RD, Smith TW, Walsh JK, Kushida CA. Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea. J Clin Sleep Med 2013;9:989-93. [PMID: 24127141 DOI: 10.5664/jcsm.3064] [Citation(s) in RCA: 74] [Impact Index Per Article: 6.2] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/26/2023]

Phillips B, Dhaon NA. Weigh the options before starting CPAP. J Clin Sleep Med 2013;9:995-6. [PMID: 24127142 DOI: 10.5664/jcsm.3066] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/13/2022]

Pan W, Kastin AJ. Leptin: a biomarker for sleep disorders? Sleep Med Rev 2013;18:283-90. [PMID: 24080454 DOI: 10.1016/j.smrv.2013.07.003] [Citation(s) in RCA: 49] [Impact Index Per Article: 4.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/26/2012] [Revised: 06/05/2013] [Accepted: 07/18/2013] [Indexed: 12/11/2022]

The role of obesity, different fat compartments and sleep apnea severity in circulating leptin levels: the Icelandic Sleep Apnea Cohort study. Int J Obes (Lond) 2012;37:835-42. [PMID: 22964793 PMCID: PMC3537909 DOI: 10.1038/ijo.2012.138] [Citation(s) in RCA: 40] [Impact Index Per Article: 3.1] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/22/2022]

Abstract

Objectives

To assess whether sleep apnea severity has an independent relationship with leptin levels in blood after adjusting for different measures of obesity and whether the relationship between OSA severity and leptin levels differs depending on obesity level.

Methods

Cross-sectional study of 452 untreated obstructive sleep apnea (OSA) patients (377 males and 75 females), in the Icelandic Sleep Apnea Cohort (ISAC), age 54.3±10.6 (mean±SD), BMI 32.7±5.3 kg/m² and apnea-hypopnea index (AHI) 40.2 ± 16.1 events/hour. A sleep study and magnetic resonance imaging of abdominal visceral and subcutaneous fat volume were performed as well as fasting serum morning leptin levels measured.

Results

Leptin levels were more highly correlated with body mass index (BMI), total abdominal and subcutaneous fat volume than visceral fat volume per se. No relationship was found between sleep apnea severity and leptin levels, assessed within three BMI groups (BMI<30, BMI 30–35 and BMI>35 kg/m²). In a multiple linear regression model, adjusted for gender, BMI explained 38.7% of the variance in leptin levels, gender explained 21.2% but OSA severity did not have a significant role and no interaction was found between OSA severity and BMI on leptin levels. However, hypertension had a significant effect on the interaction between OSA severity and obesity (p=0.04). In post-hoc analysis for nonhypertensive OSA subjects (n=249), the association between leptin levels and OSA severity explained a minor but significant variance (3.2%) in leptin levels. This relationship was greatest for nonobese nonhypertensive subjects (significant interaction with obesity level). No relationship of OSA severity and leptin levels was found for hypertensive subjects (n=199).

Conclusion

Obesity and gender are the dominant determinants of leptin levels. OSA severity is not related to leptin levels except to a minor degree in nonhypertensive nonobese OSA subjects.

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Pamidi S, Tasali E. Obstructive sleep apnea and type 2 diabetes: is there a link? Front Neurol 2012;3:126. [PMID: 23015803 PMCID: PMC3449487 DOI: 10.3389/fneur.2012.00126] [Citation(s) in RCA: 148] [Impact Index Per Article: 11.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/16/2012] [Accepted: 07/24/2012] [Indexed: 12/23/2022] Open