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For: Vargas-Mendoza N, Madrigal-Santillán E, Morales-González &, Esquivel-Soto J, Esquivel-Chirino C, González-Rubio MGLY, Gayosso-de-Lucio JA, Morales-González JA. Hepatoprotective effect of silymarin. World J Hepatol 2014; 6(3): 144-149 [PMID: 24672644 DOI: 10.4254/wjh.v6.i3.144]
URL: https://www.wjgnet.com/1948-5182/full/v6/i3/144.htm
Number Citing Articles
1
Xiaotong Sun, Jianjun Li, Zihan Wang, Qiaoling Ding, Dexin Qiu, Yong Wang. Protective effects of silymarin against diquat-induced hepatitis in layer by inhibiting oxidative stress and TLR4/MyD88/NF-κB signaling pathway. Food and Chemical Toxicology 2025; 204 doi: 10.1016/j.fct.2025.115626
2
Roberta Di Caprio, Giuseppe Monfrecola, Franco Gasparri, Raffaella Micillo, Anna Balato, Serena Lembo. Milk thistle and olive extract: old substances with a new mission against sun-induced skin damage. Giornale Italiano di Dermatologia e Venereologia 2020; 155(3) doi: 10.23736/S0392-0488.17.05726-1
3
Tzung-Hsun Tsai, Chun-Hsien Yu, Yu-Ping Chang, Yu-Ting Lin, Ching-Jang Huang, Yueh-Hsiung Kuo, Po-Jung Tsai. Protective Effect of Caffeic Acid Derivatives on tert-Butyl Hydroperoxide-Induced Oxidative Hepato-Toxicity and Mitochondrial Dysfunction in HepG2 Cells. Molecules 2017; 22(5) doi: 10.3390/molecules22050702
4
Narendra S. Bhatt, Anilkumar K. Prajapati, Gaurang B. Shah. Exploring animal models and in vitro models for liver diseases: a review. Egyptian Liver Journal 2025; 15(1) doi: 10.1186/s43066-025-00459-3
5
Zhang-He Goh, Jie Kai Tee, Han Kiat Ho. An Evaluation of the In Vitro Roles and Mechanisms of Silibinin in Reducing Pyrazinamide- and Isoniazid-Induced Hepatocellular Damage. International Journal of Molecular Sciences 2020; 21(10) doi: 10.3390/ijms21103714
6
Roshanak Khazaei, Alireza Seidavi, Mehrdad Bouyeh. A review on the mechanisms of the effect of silymarin in milk thistle (Silybum marianum) on some laboratory animals. Veterinary Medicine and Science 2022; 8(1) doi: 10.1002/vms3.641
7
Amina Ishfaq, Hafiz Muhammad Zubair, Farah Abid, Naeem Ur Rehman, Umair Ikram Dar, Shahid Muhammad Iqbal, Ali Sharif, Muhammad Saad Majeed, Muhammad Akhlaq, Samiullah Khan. Verbascum thapsus L. ethanol fraction mitigates CCl4-induced hepatic damage via inhibition of TNFα-NF-κB signaling and oxidative stress in rats. Asian Pacific Journal of Tropical Biomedicine 2025; 15(10) doi: 10.4103/apjtb.apjtb_321_25
8
Ashraf M. Abdel-Moneim, Mohammed A. Al-Kahtani, Mohamed A. El-Kersh, Mohammed A. Al-Omair, Matias A Avila. Free Radical-Scavenging, Anti-Inflammatory/Anti-Fibrotic and Hepatoprotective Actions of Taurine and Silymarin against CCl4 Induced Rat Liver Damage. PLOS ONE 2015; 10(12) doi: 10.1371/journal.pone.0144509
9
Camila S. Silva, Guilherme V. Portari, Helio Vannucchi. Molecular Aspects of Alcohol and Nutrition. 2016;  doi: 10.1016/B978-0-12-800773-0.00010-0
10
Birhanu Geta Meharie, Gedefaw Getnet Amare, Yaschilal Muche Belayneh. <p>Evaluation of Hepatoprotective Activity of the Crude Extract and Solvent Fractions of <em>Clutia abyssinica</em> (<em>Euphorbiaceae</em>) Leaf Against CCl<sub>4</sub>-Induced Hepatotoxicity in Mice</p>. Journal of Experimental Pharmacology 2020;  doi: 10.2147/JEP.S248677
11
Alibek Ydyrys. Hepatoprotective potential of medicinal plants of Kazakhstan: a review. Natural Resources for Human Health 2026; 6(4) doi: 10.53365/nrfhh/224634
12
Ashkan Hassankhani Rad, Farshid Asiaee, Sevda Jafari, Ali Shayanfar, Afsaneh Lavasanifar, Ommoleila Molavi. Poly(ethylene glycol)-poly(ε-caprolactone)-based micelles for solubilization and tumor-targeted delivery of silibinin. BioImpacts 2019; 10(2) doi: 10.34172/bi.2020.11
13
Dac Thang Hoang, Thi Thu Hien Truong, Ngo Viet Duc, Le Tuan Anh Hoang, Thi Thao Do, Le Ba Vinh, Seo Young Yang, Gao Dan, Le Tuan Anh. Hepatoprotective Effects of Extract of Helicteres hirsuta Lour. on Liver Fibrosis Induced by Carbon Tetrachloride in Rats. Applied Sciences 2021; 11(18) doi: 10.3390/app11188758
14
Shiba Samieadel, Hamid Reza Eshghizadeh, Morteza Zahedi, Mohammad Mahdi Majidi. Genotype‐specific responses of milk thistle to potassium sulfate foliar application under drought. Agronomy Journal 2025; 117(6) doi: 10.1002/agj2.70223
15
Li Ren, Tiehua Zhang, Jie Zhang. Recent advances in dietary androgen receptor inhibitors. Medicinal Research Reviews 2024; 44(4) doi: 10.1002/med.22019
16
Priyanka Upadhyay, Mousumi Bhattacharjee, Saurav Bhattacharya, Manisha Ahir, Arghya Adhikary, Prasun Patra. Silymarin-Loaded, Lactobionic Acid-Conjugated Porous PLGA Nanoparticles Induce Apoptosis in Liver Cancer Cells. ACS Applied Bio Materials 2020; 3(10) doi: 10.1021/acsabm.0c00987
17
Hasandeep Singh, Tanveer Singh, Harpal Singh Buttar, Sarabjit Kaur, Saroj Arora, Istvan G. Télessy, Balbir Singh. Biomedical Translational Research. 2022;  doi: 10.1007/978-981-16-9232-1_29
18
Ondřej Šťastník, Eva Mrkvicová, Leoš Pavlata, Andrea Roztočilová, Barbora Umlášková, Eva Anzenbacherová. Performance, Biochemical Profile and Antioxidant Activity of Hens Supplemented with Addition of Milk Thistle (Silybum marianum) Seed Cakes in Diet. Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis 2019; 67(4) doi: 10.11118/actaun201967040993
19
Jian Tan, Jianpeng Hu, Yonghui He, Feilun Cui. RETRACTED ARTICLE: Protective role of silymarin in a mouse model of renal Ischemia–Reperfusion injury. Diagnostic Pathology 2015; 10(1) doi: 10.1186/s13000-015-0436-4
20
Prarambh S.R. Dwivedi, Vishal S. Patil, Pukar Khanal, Vishwambhar V. Bhandare, Shailendra Gurav, Darasaguppe R. Harish, B.M. Patil, Subarna Roy. System biology-based investigation of Silymarin to trace hepatoprotective effect. Computers in Biology and Medicine 2022; 142 doi: 10.1016/j.compbiomed.2022.105223
21
JAMAL BASHA DUDEKULA, JEBASTIN KOILPILLAI, DAMODHARAN NARAYANASAMY. DEVELOPMENT OF GUGGULSTERONE-LOADED PHYTOSOMES: A QUALITY BY DESIGN-BASED CHARACTERIZATION AND OPTIMIZATION STUDIES. International Journal of Applied Pharmaceutics 2024;  doi: 10.22159/ijap.2024v16i5.51559
22
Thu-Ha Thi Nguyen, Hao Thi Tran, Anh-Thuy Lam, Nhu-Thuy Trinh, Hien Huu Tran, Yukio Nagasaki, Long Binh Vong. Silica-installed redox nanoparticles enable effective oral silymarin therapy for liver fibrosis. Colloids and Surfaces B: Biointerfaces 2026; 268 doi: 10.1016/j.colsurfb.2026.116000
23
Sanghita Das, Satarupa Bhattacherjee, Debojyoti De, Debbethi Bera, Parimal Karmakar, Sukhen Das, Anindita Dey. An In-Vivo Evaluation on the Ameliorative Efficacy of Piperine Incorporated Biopolymeric Nanocomposite Against Paracetamol-induced Liver Damage in Mice. BioNanoScience 2026; 16(7) doi: 10.1007/s12668-026-02686-3
24
Joyeeta Bhattacharya, Qazi Saifullah, Koustav Dutta, Subhasis Chakrabarty, Asim Halder, Suvadra Das, Ritu Khanra, Kaushik Biswas, Nagaraja Sreeharsha, Partha Roy. Comprehensive scientific insights on plant inspired nano therapeutics as the missing piece of the breast cancer puzzle. Discover Nano 2026; 21(1) doi: 10.1186/s11671-026-04621-7
25
Peng Xu, Hua Zhou, Ya-Zhuo Li, Zhong-Wen Yuan, Chang-Xiao Liu, Liang Liu, Ying Xie. Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2. Frontiers in Pharmacology 2018; 9 doi: 10.3389/fphar.2018.01115
26
Priyanka Saha, Anupam Das Talukdar, Rajat Nath, Satyajit D. Sarker, Lutfun Nahar, Jagajjit Sahu, Manabendra Dutta Choudhury. Role of Natural Phenolics in Hepatoprotection: A Mechanistic Review and Analysis of Regulatory Network of Associated Genes. Frontiers in Pharmacology 2019; 10 doi: 10.3389/fphar.2019.00509
27
Fehmi Bardak. Computational Insight into Warfarin Blockage by Silymarin Components via DFT and Molecular Docking. ChemistrySelect 2024; 9(42) doi: 10.1002/slct.202402363
28
Dianelena Eugenio-Pérez, Héctor Adolfo Montes de Oca-Solano, José Pedraza-Chaverri. Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity. Pharmaceutical Biology 2016; 54(10) doi: 10.3109/13880209.2016.1150302
29
Zaenah Zuhair Alamri. Protective and therapeutic effects of apigenin on thioacetamide-induced hepatotoxicity in male rats: physiological and morphological study. Egyptian Liver Journal 2024; 14(1) doi: 10.1186/s43066-024-00318-7
30
Dhirendra Singh, Randhir Singh, Inderjeet verma. Exploring the Multifaceted Potential of Natural Flavonoid Diosmetin in Human Diseases. Current Pharmaceutical Design 2026; 32(12) doi: 10.2174/0113816128375348250709222244
31
Borice T. Tsafack, Cyrille L. K. Bomgning, Jonas Kühlborn, Romuald T. Fouedjou, Beaudelaire K. Ponou, Remy B. Teponno, Agathe L. Fotio, Luciano Barboni, Till Opatz, Télesphore B. Nguelefack, Léon A. Tapondjou. Protective Effects of Extracts, Isolated Compounds from &lt;i&gt;Desmodium uncinatum&lt;/i&gt; and Semi-Synthetic Isovitexin Derivatives against Lipid Peroxidation of Hepatocyte’s Membranes. Advances in Biological Chemistry 2018; 8(06) doi: 10.4236/abc.2018.86009
32
Roberto Marceddu, Lucia Dinolfo, Alessandra Carrubba, Mauro Sarno, Giuseppe Di Miceli. Milk Thistle (Silybum Marianum L.) as a Novel Multipurpose Crop for Agriculture in Marginal Environments: A Review. Agronomy 2022; 12(3) doi: 10.3390/agronomy12030729
33
Bahareh Tavakoli-Far, Asieh Hosseini, Hasan Fallah-Huseini, Mahdi Mohammdi, Mahdi Goudarzvand. The Anti-diabetic Effect of the Mixture of Trigonella Foenum-graecum, Vaccinium Arctostaphylost, Silibum Marianum, dioica Urtica, Melissa Officinalis and Citrulluscolocynthis Extracts in the Diabetic Rat Animal Model and Evaluation of Possible Liver Complications.. Alborz University Medical Journal 2024; 13(4) doi: 10.61186/aums.13.4.242
34
Edén M. Rodríguez-Flores, Dulce Mata-Espinosa, Jorge Barrios-Payan, Brenda Marquina-Castillo, Mauricio Castañón-Arreola, Rogelio Hernández-Pando, Selvakumar Subbian. A significant therapeutic effect of silymarin administered alone, or in combination with chemotherapy, in experimental pulmonary tuberculosis caused by drug-sensitive or drug-resistant strains: In vitro and in vivo studies. PLOS ONE 2019; 14(5) doi: 10.1371/journal.pone.0217457
35
Te Shi, Haiyan Yue, Wen Wang, Yu Gao, Sheng Xu, Jie Gao, Chuan Yin. Emerging Approaches for the Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease: The Application of Nanomedicines. International Journal of Nanomedicine 2026;  doi: 10.2147/IJN.S603396
36
Maryam Mombeini, Ghasem Saki, Layasadat Khorsandi, Neda Bavarsad. Effects of Silymarin-Loaded Nanoparticles on HT-29 Human Colon Cancer Cells. Medicina 2018; 54(1) doi: 10.3390/medicina54010001
37
Miriam Watafua, Jane I. Ejiofor, Aminu Musa, Mubarak Hussaini Ahmad. Acacia sieberiana (Fabaceae) attenuates paracetamol and Bile Duct Ligation-Induced hepatotoxicity via modulation of biochemical and oxidative stress biomarkers. Frontiers in Pharmacology 2022; 13 doi: 10.3389/fphar.2022.959661
38
Hemlata Bhardwaj, Neeru Vasudeva, Sunil Sharma. Possible Mechanism and Pharmacological Activities of a Flavolignan Silibinin. Current Bioactive Compounds 2023; 19(7) doi: 10.2174/1573407219666230123122441
39
Miroslav Žiaran, Jindřich Kopecký. Adverse effects of targeted cancer treatment. Onkologie 2020; 14(Suppl.C) doi: 10.36290/xon.2020.051
40
Sara Verdura, Elisabet Cuyàs, Verónica Ruiz-Torres, Vicente Micol, Jorge Joven, Joaquim Bosch-Barrera, Javier A. Menendez. Lung Cancer Management with Silibinin: A Historical and Translational Perspective. Pharmaceuticals 2021; 14(6) doi: 10.3390/ph14060559
41
Sumel Ashique, Sourav Mohanto, Nitish Kumar, Sagnik Nag, Anuradha Mishra, Aritra Biswas, Mohd Rihan, Shriyansh Srivastava, Mithun Bhowmick, Farzad Taghizadeh-Hesary. Unlocking the possibilities of therapeutic potential of silymarin and silibinin against neurodegenerative Diseases-A mechanistic overview. European Journal of Pharmacology 2024; 981 doi: 10.1016/j.ejphar.2024.176906
42
S. Yousefdoost, F. Samadi, S.M. Jafari, S.S. Ramezanpour, S. Hassani, F. Ganji. Application of nanoencapsulated silymarin to improve its antioxidant and hepatoprotective activities against carbon tetrachloride-induced oxidative stress in broiler chickens. Livestock Science 2019; 228 doi: 10.1016/j.livsci.2019.08.015
43
Mona M. Mohamed, Mohammed A. Hussein, Sahar M. Elashmony, Eman R. Saifeldeen, Tamer Roshdy, Azza M. Metwaly. Optimization of Hesperidin Nanoparticles as a Promising CYP2E1 and CYP3A11 Regulator in Paracetamol-intoxicated Mice. Current Pharmaceutical Biotechnology 2026; 27(9) doi: 10.2174/0113892010336010250212060619
44
Bushra Sultana, Sadaf Yaqoob, Zohaib Zafar, Haq Nawaz Bhatti. Escalation of liver malfunctioning: A step toward Herbal Awareness. Journal of Ethnopharmacology 2018; 216 doi: 10.1016/j.jep.2018.01.002
45
Sudharshan Reddy Dachani, Mohammed Kaleem, Md. Ali Mujtaba, Nilesh Mahajan, Sayyed A. Ali, Ali F Almutairy, Danish Mahmood, Md. Khalid Anwer, Mohammad Daud Ali, Sanjay Kumar. A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer. ACS Omega 2024; 9(9) doi: 10.1021/acsomega.3c09780
46
Dinesh Mani Tripathi, Priyansha Singh, Akash Kumar Mourya, Savneet Kaur. Adaptation under Stressful Environments through Biological Adjustments and Interventions. 2023;  doi: 10.1007/978-981-99-7652-2_18
47
Mohammed Sikander, Shabnam Malik, Anyssa Rodriguez, Murali M. Yallapu, Acharan S. Narula, Sanjaya K. Satapathy, Vijian Dhevan, Subhash C. Chauhan, Meena Jaggi. Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction. Molecules 2020; 25(24) doi: 10.3390/molecules25245905
48
Kofi Busia. Perspectives on animal experimentation in herbal medicine research: ethical dilemmas and scientific progress. Journal of Herbal Medicine 2024; 46 doi: 10.1016/j.hermed.2024.100903
49
Nancy Vargas-Mendoza, Marcelo Ángeles-Valencia, Eduardo Osiris Madrigal-Santillán, Mauricio Morales-Martínez, Judith Margarita Tirado-Lule, Arturo Solano-Urrusquieta, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Tomás Fregoso-Aguilar, Ángel Morales-González, José A. Morales-González. Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training. International Journal of Molecular Sciences 2020; 21(20) doi: 10.3390/ijms21207724
50
Asmaa I. Bayomi, Sobhy Hassab El‐Nabi, Islam M. El‐Garawani, Maha Mahdy Mohamed, Samah El‐Ghlban. The Role of Milk Thistle (Silybum marianum) on Cisplatin‐Induced Genotoxicity in Albino Rats. ChemistrySelect 2026; 11(1) doi: 10.1002/slct.202503997
51
Marie Ange Djeungoue Petga, Arnaud Fondjo Kouam, Rosine Désirée Chougouo Kengne, Boris Rosnay Galani Tietcheu, Josué Simo Louokdom, Claude Bérenger Ngantchouko Ngalemo, Pascal Dieudonné Chuisseu Djamen, Paul Fewou Moundipa. Comparative assessment of hepatoprotective properties of Artesunate and flavonoids from Artemisia annua on acetaminophen and carbon tetrachloride-induced cytotoxicity in primary mice hepatocytes. Metabolism Open 2023; 18 doi: 10.1016/j.metop.2023.100241
52
Anisatu Z. Wakhidah, Dafi Al Anshory, Wendy A. Mustaqim. Ethnobotany of the Mountain Regions of Southeast Asia. Ethnobotany of Mountain Regions 2020;  doi: 10.1007/978-3-030-14116-5_83-1
53
Peter Surai. Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives. Antioxidants 2015; 4(1) doi: 10.3390/antiox4010204
54
SeungRee Seo, Gwan-Young Kim, Min-Hwan Kim, Kyung Won Lee, Min-Jae Kim, Mansingh Chaudhary, Khadka Bikram, Taeheon Kim, Seungmok Choi, Heejin Yang, Joo Won Park, Dae-Duk Kim, Ki-Taek Kim. Nanocrystal Formulation to Enhance Oral Absorption of Silybin: Preparation, In Vitro Evaluations, and Pharmacokinetic Evaluations in Rats and Healthy Human Subjects. Pharmaceutics 2024; 16(8) doi: 10.3390/pharmaceutics16081033
55
Elizabeth B. Aladejana, Adebowale E. Aladejana. Hepatoprotective activities of polyherbal formulations: A systematic review. Journal of Medicinal Plants for Economic Development 2023; 7(1) doi: 10.4102/jomped.v7i1.206
56
Alexandros Tsoupras, Kyeesha Glenn Davi. Fungi Bioactive Metabolites. 2024;  doi: 10.1007/978-981-99-5696-8_14
57
G. S. Ahammad, Y. H. Jeon, I. H. Kim. Dietary micelle quercetin: influence on performance, egg quality, and blood biochemical parameters in Hy-Line Brown laying hens. Journal of Animal and Feed Sciences 2025; 34(2) doi: 10.22358/jafs/193095/2024
58
Mirasha Hasanthi, Sehee Jo, Han-se Kim, Kwan-Sik Yun, Yeonji Lee, Kyeong-Jun Lee. Dietary supplementation of micelle silymarin enhances the antioxidant status, innate immunity, growth performance, resistance against Vibrio parahaemolyticus infection, and gut morphology in Pacific white shrimp (Litopenaeus vannamei). Animal Feed Science and Technology 2024; 311 doi: 10.1016/j.anifeedsci.2024.115953
59
Deanna M. Minich, Benjamin I. Brown. A Review of Dietary (Phyto)Nutrients for Glutathione Support. Nutrients 2019; 11(9) doi: 10.3390/nu11092073
60
Alessandro Guerrini, Luisa Vera Muscatello, Francesca del Zozzo, Valeria Harper, Lorenzo Fiorini, Ivonne Laura Archetti, Valentina Serra, Claire Carlu, Thibaut Chabrillat, Doriana Eurosia Angela Tedesco. Hepatoprotective effects of silibinin and chlorogenic acid standardised extract to alleviate the fatty liver syndrome and improve blood indices in caged-laying hens after the peak of production. Veterinary and Animal Science 2025; 30 doi: 10.1016/j.vas.2025.100522
61
Khanit Sa-ngiamsuntorn, Piyanuch Rojsanga, Pakatip Ruenraroengsak, Montree Jaturanpinyo, Chutima Petchprayoon, Somnuk Bunsupa, Veena Satitpatipan, Yongyut Pewkliang, Piyanoot Thongsri, Pongtip Sithisarn. Hepatoprotective effects of Acanthopanax trifoliatus standardized leaf extract and its formulations in a HepG2 model. BMC Complementary Medicine and Therapies 2025; 25(1) doi: 10.1186/s12906-025-05025-3
62
Xingli Tang, Opeyemi J. Olatunji, Yifeng Zhou, Xilin Hou. Allium tuberosum : Antidiabetic and hepatoprotective activities. Food Research International 2017; 102 doi: 10.1016/j.foodres.2017.08.034
63
Ning-bo Qin, Cui-cui Jia, Jun Xu, Da-hong Li, Fan-xing Xu, Jiao Bai, Zhan-lin Li, Hui-ming Hua. New amides from seeds of Silybum marianum with potential antioxidant and antidiabetic activities. Fitoterapia 2017; 119 doi: 10.1016/j.fitote.2017.04.008
64
Efrata Citra Manta Surbakti, Poppy Anjelisa Zaitun Hasibuan, Denny Satria, Panal Sitorus, Aminah Dalimunthe, Syukur Berkat Waruwu. Analysis of artocarpin content and hepatoprotective activity of ethanol extract of mobe (Artocarpus lacucha Buch-Ham.) leaves on the liver of rats induced by paracetamol. Phytomedicine Plus 2025; 5(2) doi: 10.1016/j.phyplu.2025.100747
65
Hamid-Reza Behboodi, Morteza Asghari-Moghadam, Mehran Mehri. Impact of varying levels of HepatoMax in drinking water on liver performance and blood profiles in broiler chickens. Veterinary and Animal Science 2026; 32 doi: 10.1016/j.vas.2026.100610
66
Sandeep B. Subramanya, Balaji Venkataraman, Mohamed Fizur Nagoor Meeran, Sameer N. Goyal, Chandragouda R. Patil, Shreesh Ojha. Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury. International Journal of Molecular Sciences 2018; 19(12) doi: 10.3390/ijms19123776
67
Jessyca Karen Pinheiro, Lara Toledo Henriques, Severino Gonzaga Neto, Ricardo Dias Signoretti, Juliana Silva de Oliveira, Jovanna Karine Pinheiro, Renato Tonhá Alves Júnior. Uso da homeopatia no gado de leite como modulador da função hepática: uma revisão. CES Medicina Veterinaria y Zootecnia 2021; 16(1) doi: 10.21615/cesmvz.16.1.2
68
Negin Mirzaei, Shahideh Jahanian Sadatmahalleh, Safoura Rouholamin, Malihe Nasiri. A randomized trial assessing the efficacy of Silymarin on endometrioma-related manifestations. Scientific Reports 2022; 12(1) doi: 10.1038/s41598-022-22073-8
69
Golam Sagir Ahammad, In Ho Kim. Micelle‐Based Phytogenic Compounds in Nonruminant Nutrition: A Review. Journal of Animal Physiology and Animal Nutrition 2025; 109(6) doi: 10.1111/jpn.70009
70
Yi-An Zhang, Xi-Zhong Shen, Ji-Min Zhu, Tao-Tao Liu. Extensive Metastatic Cholangiocarcinoma Associated With IgG4-Related Sclerosing Cholangitis Misdiagnosed as Isolated IgG4-Related Sclerosing Cholangitis. Medicine 2015; 94(45) doi: 10.1097/MD.0000000000002052
71
J.A. Velarde-Ruiz Velasco, M.F. Higuera-de la Tijera, G.E. Castro-Narro, F. Zamarripa-Dorsey, J.M. Abdo-Francis, I. Aiza Haddad, J.M. Aldana Ledesma, M.V. Bielsa-Fernández, E. Cerda-Reyes, L.E. Cisneros-Garza, R. Contreras-Omaña, A. Reyes-Dorantes, N.J. Fernández-Pérez, E.S. García-Jiménez, M.E. Icaza-Chávez, D. Kershenobich-Stalnikowitz, M.A. Lira-Pedrín, R. Moreno-Alcántar, J.L. Pérez-Hernández, M.V. Ramos-Gómez, M.T. Rizo-Robles, S. Solana-Sentíes, A. Torre-Delgadillo. Consenso Mexicano de hepatitis alcohólica. Revista de Gastroenterología de México 2020; 85(3) doi: 10.1016/j.rgmx.2020.04.002
72
Sathish Kumar Mungamuri, Yamini Javvadi. Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers. 2020;  doi: 10.1007/978-3-030-48405-7_12
73
Andrea Mega, Luca Marzi, Michael Kob, Andrea Piccin, Annarosa Floreani. Food and Nutrition in the Pathogenesis of Liver Damage. Nutrients 2021; 13(4) doi: 10.3390/nu13041326
74
Hee Ryeong Lim, Young-Su Yi. Silymarin in Silybum marianum ameliorated acute lethal sepsis in mice by targeting caspase-11 noncanonical inflammasome in macrophages. Journal of Ethnopharmacology 2026; 355 doi: 10.1016/j.jep.2025.120742
75
Wen-Long Sun, Sha Hua, Xin-Yu Li, Liang Shen, Hao Wu, Hong-Fang Ji. Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin. Nature Communications 2023; 14(1) doi: 10.1038/s41467-023-36079-x
76
Sarah M. El-Kot, Wessam Wanas, Afaf M. Hafez, Nihal A. Mahmoud, Amina M. Tolba, Abeer H. Younis, Gamal El Sayed, Huda E. Abdelwahab. Effect of silymarin on the relative gene expressions of some inflammatory cytokines in the liver of CCl4-intoxicated male rats. Scientific Reports 2023; 13(1) doi: 10.1038/s41598-023-42250-7
77
Aline Maria Stolf, Cibele Campos Cardoso, Alexandra Acco. Effects of Silymarin on Diabetes Mellitus Complications: A Review. Phytotherapy Research 2017; 31(3) doi: 10.1002/ptr.5768
78
Hanaa R. Aboelwafa, Attalla F. El-kott, Eman M. Abd-Ella, Hany N. Yousef. The Possible Neuroprotective Effect of Silymarin against Aluminum Chloride-Prompted Alzheimer’s-Like Disease in Rats. Brain Sciences 2020; 10(9) doi: 10.3390/brainsci10090628
79
Z.M.M. Omar, A.A.-N. Ahmed, M.H. El-Bakry, M.A. Ahmed, A. Hasan. Metformin versus silymarin as hepatoprotective agents in mice fibrotic model caused by carbon tetrachloride. Annales Pharmaceutiques Françaises 2022; 80(5) doi: 10.1016/j.pharma.2022.01.005
80
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Xiangpeng Wang, Lulu Wu, Quanshu Zhang, Lili Li, Yanni Xie, Xing Wan, Hao Wu, Yang Xiang. Methyl 3,4-dihydroxybenzoate protects against d-galN/LPS-induced acute liver injury by inhibiting inflammation and apoptosis in mice. Journal of Pharmacy and Pharmacology 2019; 71(7) doi: 10.1111/jphp.13091
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Joana Mota, Catarina Faria-Silva, Ana Resendes, Maria Isabel Santos, Manuela Colla Carvalheiro, Ana Lima, Sandra Simões. Silymarin inhibits dermal gelatinolytic activity and reduces cutaneous inflammation. Natural Product Research 2025; 39(16) doi: 10.1080/14786419.2024.2347452
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Ava Karimian, Iman Karimzadeh, Mojtaba Shafiekhani, Reza Heidari, Fatemeh Masjedi, Fatemeh Izadi, Nazanin Barshan-Tashnizi, Sandra L. Kane-Gill, Laleh Mahmoudi. Protective effects of silymarin on preventing vancomycin nephrotoxicity in infectious patients: a randomized, double-blinded, placebo-controlled, pilot clinical trial. Naunyn-Schmiedeberg's Archives of Pharmacology 2025; 398(3) doi: 10.1007/s00210-024-03372-5
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Josif Vidimce, Evan Noel Pennell, Maxmilian Foo, Ryan Graeme Shiels, Sapha Shibeeb, Michael Watson, Andrew Cameron Bulmer. Effect of Silymarin Treatment on Circulating Bilirubin and Cardiovascular Disease Risk Factors in Healthy Men: A Single‐Blind, Randomized Crossover Trial. Clinical Pharmacology in Drug Development 2021; 10(10) doi: 10.1002/cpdd.962
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Abdulrahman A. Aljabri, Turki Hathal Alfehaidi, Amer Fadhi Alarawi, Suhayb W. Alamri, Faris S. Alnezary, Mohammed H. Alsubhi, Ammar Abdulraheem Bahauddin, Abdulrahman G. Alharbi, Heba M. Zahid, Lujain A. Almohammadi, Bandar D. Alrehaili, Heba Eltahir. Hepatoprotective Effects of Ajwa Seed Oil Against CCl4-Induced Acute Liver Injury in Mice. International Journal of Pharmacology 2026; 22(2) doi: 10.31083/IJP49020
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Surya Amal, Himyatul Hidayah, Neni Sri Gunarti , Dhavid Twua Mangunsong . Uji Hepatoprotektif Fraksi N-Heksana Kulit Batang Jamblang (Syzygium Cumini (L.) Skeels) Ditinjau Dari Kadar Ast, Alt, Dan Albumin. Journal of Pharmaceutical and Sciences 2026;  doi: 10.36490/journal-jps.com.v9i1.1291
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Katia Azarfar, Parichehreh Yaghmaei, Mahsa M. Amoli, Nasim Hayati-Roodbari, Azadeh Ebrahim-Habibi. Local Insulin-Derived Amyloidosis Model Confronted with Silymarin: Histological Insights and Gene Expression of MMP, TNF-α, and IL-6. International Journal of Molecular Sciences 2022; 23(9) doi: 10.3390/ijms23094952
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Kyung Do Kim, Jeehyoung Shim, Ji-Hun Hwang, Daegwan Kim, Moaine El Baidouri, Soyeon Park, Jiyong Song, Yeisoo Yu, Keunpyo Lee, Byoung-Ohg Ahn, Su Young Hong, Joong Hyoun Chin. Chromosome-level genome assembly of milk thistle (Silybum marianum (L.) Gaertn.). Scientific Data 2024; 11(1) doi: 10.1038/s41597-024-03178-3
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Tae-Won Kim, Dong-Ryung Lee, Bong-Keun Choi, Hwan-Kyu Kang, Ju-Young Jung, Seol-Wa Lim, Seung Hwan Yang, Joo-Won Suh. Hepatoprotective effects of polymethoxyflavones against acute and chronic carbon tetrachloride intoxication. Food and Chemical Toxicology 2016; 91 doi: 10.1016/j.fct.2016.03.004
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Eun-Sun Choi, Sejun Oh, Boonsil Jang, Hyun-Ju Yu, Ji-Ae Shin, Nam-Pyo Cho, In-Hyoung Yang, Dong-Hoon Won, Hye-Jeong Kwon, Seong Doo Hong, Sung-Dae Cho. Silymarin and its active component silibinin act as novel therapeutic alternatives for salivary gland cancer by targeting the ERK1/2-Bim signaling cascade. Cellular Oncology 2017; 40(3) doi: 10.1007/s13402-017-0318-8
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Hany Elsawy, Abdullah M. Alzahrani, Manal Alfwuaires, Azza Sedky, Eman E. El- Trass, Omar Mahmoud, Ashraf M. Abdel-Moneim, Mahmoud Khalil. Analysis of silymarin-modulating effects against acrylamide-induced cerebellar damage in male rats: Biochemical and pathological markers. Journal of Chemical Neuroanatomy 2021; 115 doi: 10.1016/j.jchemneu.2021.101964
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Jun Liang, Ying Liu, Jinguang Liu, Zhe Li, Qiangyuan Fan, Zifei Jiang, Fei Yan, Zhi Wang, Peiwen Huang, Nianping Feng. Chitosan-functionalized lipid-polymer hybrid nanoparticles for oral delivery of silymarin and enhanced lipid-lowering effect in NAFLD. Journal of Nanobiotechnology 2018; 16(1) doi: 10.1186/s12951-018-0391-9
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Andrea Trabalzini, Marco Fornaciari, Desirée Bartolini, Ina Varfaj, Roccaldo Sardella, Martina Paiella, Guglielmo Sorci, Fabio Orlandi. Influence of Agronomic Practices on the Antioxidant Activity of Three Mediterranean Officinal Wild Plants: Silybum marianum, Achillea millefolium, and Trifolium pratense. Applied Sciences 2025; 15(9) doi: 10.3390/app15095153
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Muhammad Mustafa, Aiman Tariq, Muhammad Khisroon, Aiman Mehroon, Aaliya Saleem, Bushra Arshad. Silymarin Protects Against Daunorubicin‐Induced DNA Damage in an In Vivo Comet Assay. Environmental and Molecular Mutagenesis 2026; 67(8-9) doi: 10.1002/em.70080
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Fariba Aghaei, Ehsan Arabzadeh, Foad Feizolahi, Ali Nejati Bezdi, Majid Abasi, Mehdi Zargani. Boosting muscle health in aging rats: The synergistic effect of vitamin C, silymarin, and endurance swimming on a high-fat diet. Tissue and Cell 2026; 99 doi: 10.1016/j.tice.2025.103290
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Golam Sagir Ahammad, Se Yeon Jang, In Ho Kim. Effects of micelle silymarin in corn-soybean meal-based diet on laying hens' performance, egg quality, and blood profile, with comparative assessment of blood absorption rates between powdered and micelle silymarin. Poultry Science 2024; 103(10) doi: 10.1016/j.psj.2024.104029